DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and lsd2

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_592937.1	Gene:	lsd2 / 2541832	PomBaseID:	SPAC23E2.02	Length:	1273	Species:	Schizosaccharomyces pombe

Alignment Length:	913	Identity:	188/913 - (20%)
Similarity:	319/913 - (34%)	Gaps:	243/913 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTQFGGSSSKMTEPIEYVTLISDDSDGE--PTPKRNVNHPPSALSAPNPGQKQKHPDEDSNDAPA 65
            |:.|....|.|...:...|.:|...|..  |.|....   |:.:|.|            ::..|.
pombe   278 PSTFRNHESFMPTQLVSATELSKSVDNAVLPIPPTTA---PAVVSPP------------ASSFPL 327

  Fly    66 TSDERRTSRRNRPKV---DYSNRPSGSGDTASNDKSGSASMGPNNQQAERRSQSQTRKSEANATS 127
            .|....:...:.|.:   :...||           .||.::.|:....:..||           |
pombe   328 MSSAATSGNISSPALFDSELGARP-----------EGSVAIEPSRVLLQWSSQ-----------S 370

  Fly   128 SSVSGPSAGNSRPSQNGDSKDRDAG--------TPTVLSGQEGAVFQSRL--PFNKMTPNEEACF 182
            ||.:.||||.|.|:.:..|....|.        .|..|...|..:...||  |.
pombe   371 SSHTIPSAGASIPTSSLKSFFEHAAEAARKCNLDPRALESFEQHMLSDRLHDPV----------- 424

  Fly   183 PDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLS-------------FEIALKNLPPPFDSEPSL 234
                   :|.|  :..||||:..:|:.||...:|             |::|            ||
pombe   425 -------VLFH--YFQIRNSICWLWIKNPTHAISRVEAQGVCVDRCLFQLA------------SL 468

  Fly   235 VRRVHSFLERHGFINFGIFK-----------RLKPIPAKKLGKVIVIGAGISGLAVAHQL----Q 284
               .:.||.|:|:||:|...           ......|.|...:.|:|||::||..|.||    .
pombe   469 ---AYEFLVRYGYINYGCLSFDSSFTNETNTGTTSSSASKQKTIAVVGAGLTGLICARQLTGLFS 530

  Fly   285 QFGMD----------VIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDL 339
            |:...          ||:|||::|.||||  :.:...::...|..:.....|..:|.|....::
pombe   531 QYSSSFLSKNELPPKVIILEAKERTGGRI--YSRALPVSHTSATQINHHTSNSNSISSNSTSLN- 592

  Fly   340 VPIQQTCPLYGPDG---------KPVPKEKDDVIEREFNRLL--ESASYLSHRLDFNYAGDCPVS 393
             |...|.|.:.|..         .|:    ||::....|:.|  |........|.::
pombe   593 -PKDVTDPSHIPSAIDLGFQFLFSPM----DDILLNLLNKQLGIEVTEMTGSDLVYD-------- 644

  Fly   394 LGDALEWIISMQEMQVMHKRGQHMQEIIATQTKI-IEQRRRLKTLRDTIGKLKNEHLAMINQRKP 457
              :....::.|.|::.::...:.:.|.::....| :|:..|:..:        ::....|::..|
pombe   645 --ETDTKVLDMVEVKKLNILWEKLLEYVSVCFFINVEESVRISWI--------SQFQLFIDEMFP 699

  Fly   458 KGTDGDLKY-CYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLI 521
            ......|.. ...||:.:.|.:.:.:.:|::..|...:|:.|.
pombe   700 DHLSKSLSLNASHEFSFKKTMLILIDEVSSYAKLGNSQKKFLI---------------------- 742

  Fly   522 LDWHFANLEFANAT-RLNNLSLKHWDQDDDF-EFIGHHTTVRNGYSCVPVAL---TENLDIRVNS 581
              |.|...|..:.. .||.:       |.|| :.|......|.|.|.:|.||   ...|:|....
pombe   743 --WCFKVAELDDTLYPLNTV-------DTDFSKDILIPKVARRGLSQLPWALQSYPSPLNIHYEK 798

  Fly   582 AVKEIKYGTKGVEVVAENLKTS---NSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPP 643
            .|.         :|..||.|.:   ....:|:.|.||           :|...|..|:.::|.|.
pombe   799 FVS---------KVTIENDKCTLDCKDNSSYEVDQVV-----------IACSPSHFSSNIEFSPG 843

  Fly   644 LPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASR-------GE---MFLFWSI 698
            ||::..:.||.:.|....||:|.:...||..|...||.:..:.:..       |:   :...|::
pombe   844 LPNFVTENIKSIDFKPGKKVILRYAAAFWRKNIRSFGIIPKSLSQEMNNDENDGKSCFVLRIWNM 908

  Fly   699 SSSPVLLALVAGMAANLVESVTDDI--IIGRCMSVLKNIFGNTSVPQPK--ETVVTRWRSDPWAR 759
            .....:..|||.:...:..|.:::.  :|....|::.:.|.|.|.....  :..||.|..:....
pombe   909 LPETGVPILVADINPQMTSSSSNETSHLIQELHSLIVDHFQNDSNSSADLLDAWVTNWSRNGVYD 973

  Fly   760 GSYSYVSVGSSGSDYDLLAAPVIPPSSKDAEGLPRLFFAGEHTIRNYPA-TVHGAYLSGLREAGR 823
            |..||.:..:....|:....     .|:.:..|.||..||::....... |:..::||||.....
pombe   974 GLNSYPNFANDKQQYEKRFR-----QSQLSYNLGRLHIAGDYIFSCVGCRTLQRSFLSGLSVCTG 1033

  Fly   824 IAD 826
            |.|
pombe  1034 IID 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	22/99 (22%)
		NAD_binding_8	269..327	CDD:290186	21/71 (30%)
		Amino_oxidase	274..824	CDD:279874	120/599 (20%)
lsd2	NP_592937.1	SWIRM	397..481	CDD:282311	25/118 (21%)
		NAD_binding_8	511..>565	CDD:290186	20/55 (36%)
		Amino_oxidase	516..1035	CDD:279874	120/600 (20%)
		HMG-box	1116..1188	CDD:238037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1420
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	1	1.000	-	-		otm47214
orthoMCL	1	0.900	-	-		OOG6_103427
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2101
TreeFam	0	0.000	Not matched by this tool.
	8	7.760