DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and KDM1A

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	XP_006710537.1	Gene:	KDM1A / 23028	HGNCID:	29079	Length:	878	Species:	Homo sapiens

Alignment Length:	885	Identity:	451/885 - (50%)
Similarity:	581/885 - (65%)	Gaps:	87/885 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTQFGGSS---------SKMTEPIEYVTLISDDSDGEPTPKRNV---NHPPSALSAPNPGQ--KQ 53
            |...|||.         :.::.|.|    :...:.||.||::..   ..||..|:.| ||.  .|
Human    25 PGTAGGSENGSEVAAQPAGLSGPAE----VGPGAVGERTPRKKEPPRASPPGGLAEP-PGSAGPQ 84

  Fly    54 KHPDEDSNDA-------PATSDERRTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAE 111
            ..|......|       ..|.:.||||||.|.||:|........:.:.::   ..|....|.:||
Human    85 AGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDE---YYSEEERNAKAE 146

  Fly   112 RRSQ-----SQTRKSEANATSSSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPF 171
            :..:     .|....|.|.:........||..:...:|...|..|      ||.|||.||||||.
Human   147 KEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQDDSSGGYGDGQA------SGVEGAAFQSRLPH 205

  Fly   172 NKMTPNEEACFPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLVR 236
            ::||..|.||||||........:|||.|||..|.:|:|||||||:||..|:.|..|::|:..||.
Human   206 DRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVH 270

  Fly   237 RVHSFLERHGFINFGIFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGG 301
            ||||:|||||.|||||:||:||:|.||.||||:||:|:||||.|.|||.|||||.:|||||||||
Human   271 RVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 335

  Fly   302 RISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIER 366
            |::||||.:|:||:|||||||:.||||.::|||:.|:|..|:|.||||..:|:.||||||:::|:
Human   336 RVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQ 400

  Fly   367 EFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQR 431
            |||||||:.|||||:||||...:.|||||.|||.:|.:||..|..::.:|.::|:.||.::.|..
Human   401 EFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELL 465

  Fly   432 RRLKTLRDTIGKLKNEHLAMINQRKP---------KGTDGDLKYCYQEFN-IRNTQIKMEETIST 486
            .::..|::.|.:|..::......:.|         |....||....:|:: :..||.|:||
Human   466 NKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEE---- 526

  Fly   487 FHDLHAEEKQMLAKLHELEQNRP------SDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHW 545
                         ||.|||.|.|      ||||||||||.|||||||||||||||.|:.||||||
Human   527 -------------KLQELEANPPSPLFFCSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHW 578

  Fly   546 DQDDDFEFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYK 610
            ||||||||.|.|.|||||||||||||.|.|||::|:||::::|...|.||:|.|.::::....||
Human   579 DQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYK 643

  Fly   611 ADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPN 675
            .|.|:|||.|||||        ||...|:|.||||:||..|::|:||||||||||||||:||||:
Human   644 CDAVLCTLPLGVLK--------QQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS 700

  Fly   676 ANLFGHVGSTTASRGEMFLFWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTS 740
            .|||||||||||||||:||||::..:|:|||||||.||.::|:::||:|:|||:::||.|||:::
Human   701 VNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSA 765

  Fly   741 VPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIP-PSSKDA-EGLPRLFFAGEHTI 803
            |||||||||:|||:|||||||||||:.||||:||||:|.|:.| ||...| :.:|||||||||||
Human   766 VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTI 830

  Fly   804 RNYPATVHGAYLSGLREAGRIADYYLG----YPEGTPPDI 839
            ||||||||||.||||||||||||.:||    .|....|.:
Human   831 RNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGV 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	48/84 (57%)
		NAD_binding_8	269..327	CDD:290186	41/57 (72%)
		Amino_oxidase	274..824	CDD:279874	330/567 (58%)
KDM1A	XP_006710537.1	SWIRM	197..284	CDD:282311	49/86 (57%)
		NAD_binding_8	303..361	CDD:290186	41/57 (72%)
		Amino_oxidase	308..851	CDD:279874	330/567 (58%)
		SurA_N_3	<395..491	CDD:304439	38/95 (40%)
		NAT_SF	<441..>549	CDD:302625	31/124 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158484
Domainoid	1	1.000	670	1.000	Domainoid score	I145
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32240
Inparanoid	1	1.050	834	1.000	Inparanoid score	I454
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52579
OrthoDB	1	1.010	-	-		D1034142at2759
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	1	1.000	-	-		oto89702
orthoMCL	1	0.900	-	-		OOG6_103427
Panther	1	1.100	-	-	LDO	PTHR10742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	1	1.000	-	-		X2101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800