DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)3-3 and amx-2

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001369790.1	Gene:	amx-2 / 173146	WormBaseID:	WBGene00000138	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	484	Identity:	105/484 - (21%)
Similarity:	176/484 - (36%)	Gaps:	138/484 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 VIVIGAGISGLAVAHQLQQF--GMDVIVLEARDRVGGRI--STF--RKNSYIADVGAMVVTGVYG 325
            |||:|||::||..|..:||.  |:.|:|||||.:|||||  :|.  |......|.|:..::....
Worm    48 VIVVGAGLTGLTAARNIQQNRPGLSVLVLEARGQVGGRIRYATMQTRNGVEFVDTGSQFISPTDT 112

  Fly   326 NPMTILSKQIGMDLVPIQQ-TCPLYGPDG--KPVPKEKDDVIEREFNRLLESASYLSHRLDFNYA 387
            ..::::.:   :::...|| ||   |.:.  :...|::...::::::..|           |...
Worm   113 QLLSLIQE---LNVRTTQQLTC---GNNTVFQQTRKKRQLSLQQQWSTTL-----------FTDL 160

  Fly   388 GDCPVSLGDALEWIISMQEMQV---------------MHKRGQHMQEIIATQTKIIEQRRRLKTL 437
            .:.|.:||:.....:|....|:               ....|:.:.||....|...:....::.|
Worm   161 INSPETLGNLTNTSVSAMSQQMDTADADSVNRMMQTFFDAPGEQVPEIQLALTCSSQNATAVEIL 225

  Fly   438 R---------------DTIGKLKNEHLAMINQRKPKGTDGDLKYCYQ-----EFNIRNTQIKMEE 482
            |               :.:.:|.:..|...:||.....|.......|     .|:.|  |:.:..
Worm   226 RRFGHGQSLLAQGGMNEVVRRLADGLLIEYSQRVVSVNDAAFPAVVQTSAGRRFSGR--QVIVAV 288

  Fly   483 TISTFHDLH---AEEKQMLAKLHELEQN-RPSD-----------------------VYLSSRDRL 520
            .|.|..::.   |.|    |...:|.|| .|:.                       :|.|:...|
Worm   289 PIPTLENIELVPAPE----APFQQLIQNYGPTGHAYYFTMSFQRATWRLNGRSGKVIYTSATGPL 349

  Fly   521 I----LDWHFA----NLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYS-----CVPVALT 572
            :    .|..||    |...|::|.   ..:.|:..|..||      |.|..|:     .:..|..
Worm   350 VWLTTFDTTFAASCDNSTSASSTL---WGIAHFSYDVPFE------TRRKLYTQAIMYSLRFADF 405

  Fly   573 ENLDIR-VNSAVKEIKYG---TKGVEVVAENLKTSNS-----QMTYKADLVVCTLTLGVLKVAVA 628
            ..||:. ||.|..::..|   |..:.:..|:||..|.     |..:.|...:.:..||.:..||.
Worm   406 SPLDVSDVNFATDDLAKGTIPTLKLNIPLESLKYLNDFHTLYQNVHIATADIASHNLGTMNGAVH 470

  Fly   629 HKES-------------QQSNTVKFDPPL 644
            ...|             .|||.|..|.|:
Worm   471 AAGSVSTYVLQMLSAADAQSNGVLRDTPV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311
		NAD_binding_8	269..327	CDD:290186	25/63 (40%)
		Amino_oxidase	274..824	CDD:279874	99/477 (21%)
amx-2	NP_001369790.1	Amino_oxidase	55..472	CDD:396255	92/448 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910