DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)3-3 and kdm1b

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	XP_002932724.1	Gene:	kdm1b / 100489838	XenbaseID:	XB-GENE-982183	Length:	821	Species:	Xenopus tropicalis

Alignment Length:	760	Identity:	218/760 - (28%)
Similarity:	328/760 - (43%)	Gaps:	208/760 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 KSEANATSSSVSGPSAGNSRPS--------QNGDS----KDRDAGTPTVLSGQEGAVFQSRLPFN 172
            |...:||..:...|......||        :.|.|    :.|.|....|.|| ....||   ||.
Frog   212 KDSPSATLLAAYYPDCVGMSPSCTSTNRLHREGHSGKLDQSRGASANAVASG-INPYFQ---PFY 272

  Fly   173 KMTPNE---EAC-------------FPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIAL 221
            :  |||   ..|             ||:.||...:    :|.:||.:|.:|..|.|     |:
Frog   273 Q--PNECGKALCVRPDVMELDELYEFPEYSRDPTM----YLALRNLILALWHINCK-----EV-- 324

  Fly   222 KNLPPPFDSEPSLVR------------RVHSFLERHGFINFGIFKRLKP----IPAKKLGK-VIV 269
              |.|...|...:||            |:..|:.|.|.:|.|:.. :.|    :|.:...| |||
Frog   325 --LTPQICSHHIMVRGLVRIRCVQEMERILYFMSRKGLVNTGVLS-VSPGQYLLPKEYHNKSVIV 386

  Fly   270 IGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRI---STFRKNSYIADVGAMVVTGVYGNPMTIL 331
            ||||.:|||.|.||..||:.|.|:|||||:|||:   .:|:  ..|...||.:|.|...||:.|:
Frog   387 IGAGPAGLAAARQLHNFGIKVTVVEARDRIGGRVWDEKSFK--GVIVGKGAQIVNGCINNPIAIM 449

  Fly   332 SKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGD 396
            .:|||:.:..:::.|               |:|| |..||.:.|  :..|:||::.....|
Frog   450 CEQIGIKMRKLREKC---------------DLIE-EGGRLTDPA--IDKRMDFHFNAVLDV---- 492

  Fly   397 ALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTD 461
            ..||                               |:.||.               ||..|.|.
Frog   493 VAEW-------------------------------RKDKTQ---------------NQDAPLGD- 510

  Fly   462 GDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHF 526
                             |::|....|                   .:.|.:..:..:..:|.:|.
Frog   511 -----------------KIQEICKAF-------------------TQESGIQFTDVEEKVLQFHL 539

  Fly   527 ANLEFANATRLNNLSLKHWDQDDDF-EFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGT 590
            .|||:|..:.|:.:|.:.||.::.| :|.|.||.:..|||.|...|.|.||||:|:.::.:.|.:
Frog   540 GNLEYACGSNLHKVSARSWDHNEFFAQFAGDHTMLGAGYSMVIDKLAEGLDIRLNTPIRNVDYTS 604

  Fly   591 KGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRL 655
            :.|.:      |:....|:.|...:.|:.|.:|          |...::|:|.||:.|.:||..|
Frog   605 QEVRI------TAADGQTFTAQKALVTVPLALL----------QKGAIQFNPLLPEKKVKAIHSL 653

  Fly   656 GFGNLNKVVLCFDRIFWD---PNANLFGHVGSTTASRGEMFLFWSI---SSSPVLLALVAGMAAN 714
            |.|.:.|:.|.|...|||   ..|:.|||:......||...:|:.:   ....||::::.|.|..
Frog   654 GAGVIEKIALQFPYRFWDNKIQGADFFGHIPPNCNKRGLFGVFYDMDPEGKHAVLMSVITGDAVT 718

  Fly   715 LVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAA 779
            .::.:.|..::.:||.:|:.:|....||.|.:..||.|..||||..:||:|..|.||..||:||
Frog   719 SIQELEDKQVVKQCMVILREVFKEQEVPAPIKYFVTHWAKDPWAHMAYSFVKTGGSGEAYDILA- 782

  Fly   780 PVIPPSSKDAEGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRI 824
                   :|.:|  ::|||||.|.|::|.||.||||||:|||.:|
Frog   783 -------EDIQG--KIFFAGEATNRHFPQTVSGAYLSGVREASKI 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	29/112 (26%)
		NAD_binding_8	269..327	CDD:290186	29/60 (48%)
		Amino_oxidase	274..824	CDD:279874	163/559 (29%)
kdm1b	XP_002932724.1	zf-CW	138..191	CDD:369393
kdm1b	XP_002932724.1	PLN02328	<301..818	CDD:215187	193/663 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1034142at2759
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950