Protein Alignment Su(var)3-3 and Lao1

DIOPT Version :10

• Sequence 1: NP_649194.1
• Gene: Su(var)3-3 / 40217
• FlyBaseID: FBgn0260397
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_598653.3
• Gene: Lao1 / 100470
• MGIID: 2140628
• Length: 523
• Species: Mus musculus
• Alignment Length: 674
• Identity: 138/674 - (20%)
• Similarity: 244/674 - (36%)
• Gaps: 210/674 - (31%)

  Fly   187 RSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLVRRVHSFLERHGFINFG 251
            :||||...:.|.:.:.|           ..:|..:|....| |.|..|:      :.::|
Mouse     9 KSGILVWGILLCVSSCL-----------ALYENLVKCFQDP-DYEAFLL------IAQNG----- 50

  Fly   252 IFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVG 316
                |...|..|  :|:|:|||::||..|..||..|.:|.:|||.:.:|||:.|.|
Mouse    51 ----LHTSPLSK--RVVVVGAGMAGLVAAKTLQDAGHEVTILEASNHIGGRVVTLR--------- 100

  Fly   317 AMVVTGVYGNPMTILSKQIG--MDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLS 379
                           :|:.|  ::|.|::            :|:                    |
Mouse   101 ---------------NKEEGWYLELGPMR------------IPE--------------------S 118

  Fly   380 HRLDFNYAGDCPVSLG-----DALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRD 439
            |:|...|.....:.|.     |:..|.:       ::.:.....|::| ...|:....|......
Mouse   119 HKLIHTYVQKLGLKLNKFHQYDSNTWYL-------LNGQRYRASEVMA-NPGILGYPLRPSEKNK 175

  Fly   440 TIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHEL 504
            |:..|..:.:..|...:.......|...|..::.:...:| |.|:|         |..:..:.::
Mouse   176 TVTDLFYQAITKIKPHRKTSNCSQLLSLYDSYSTKAYLMK-EGTLS---------KGAIEMIGDI 230

  Fly   505 EQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSCVPV 569
             .|..:..|.|..:.|               |:.::    :.:.|.|      :.:..|:..:|.
Mouse   231 -MNENAGYYKSLLESL---------------RIASI----FSKSDQF------SEITGGFDQLPN 269

  Fly   570 ALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQ 634
            .|:.:|      ....|:.|:|...||.:..|.   ::.|:.|.....|.......|:....::.
Mouse   270 GLSASL------KPGTIRLGSKVERVVRDGPKV---KVMYRTDGPTSALHKLTADYAIITASAKA 325

  Fly   635 SNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSIS 699
            :..:.|.|||...|..|::.:.:.:..||||..:..||:.:....|:   :...|...|:::...
Mouse   326 TRLITFQPPLSREKTHALRSVHYTSATKVVLVCNERFWEQDGIRGGY---SITDRPSRFIYYPSH 387

  Fly   700 SSP----VLLA---------LVAGMAAN-LVESVTDDIIIGRCMSVLKNIFGNTSVPQPKE---- 746
            |.|    ||||         ..|.:..| :|:.|.||      ::.:..|        |||
Mouse   388 SLPGGKGVLLASFTVGDDSSFFAALKPNQVVDVVLDD------LAAVHRI--------PKEELKR 438

  Fly   747 ----TVVTRWRSDPWARGS------YSYVSVGSSGSDYD-LLAAPVIPPSSKDAEGLPRLFFAGE 800
                :.:..|..||...|:      |.:|       ||. .|:.|         ||  |::||||
Mouse   439 MCPKSAIKHWSLDPLTIGAFTEFTPYQFV-------DYSKQLSQP---------EG--RIYFAGE 485

  Fly   801 HTIRNYPATVHGAYLSGLREAGRI 824
            ||...: :.:..|..||:|.:..|
Mouse   486 HTCLPH-SWIDTAIKSGIRASCNI 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	PLN03000	74..>827	CDD:178578	138/674 (20%)
Lao1	NP_598653.3	YobN	51..512	CDD:440844	125/605 (21%)