DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-3 and kdm1a

DIOPT Version :9

Sequence 1:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	XP_002936640.1	Gene:	kdm1a / 100216250	XenbaseID:	XB-GENE-5816927	Length:	833	Species:	Xenopus tropicalis

Alignment Length:	851	Identity:	438/851 - (51%)
Similarity:	569/851 - (66%)	Gaps:	84/851 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSSKMTEPIEYVTLISDDSDG-EPTPKRNVNHPPSA----------LSAPNPGQKQKHPDEDSND 62
            |||..:.....:....|.:.| |.||::.....|.|          ::....||
Frog    32 SSSSSSSSSSGIMASPDTAAGLERTPRKKERASPGAEHGASTAPGIMAGAEGGQ----------- 85

  Fly    63 APATSDERRTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAERRSQSQTRKSEANATS 127
             |.|.:.||||||.|.||:|........: .|.|:..|        :.||.::::..|...
Frog    86 -PETPEGRRTSRRKRAKVEYREMDESLAN-LSEDEYYS--------EEERNARAEKEKKVP---- 136

  Fly   128 SSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNEEACFPDISRSGILG 192
                 |....:.|.:..||:      |...||.|||.||||||.::||..|.||||||.......
Frog   137 -----PPPPQAPPEEENDSE------PEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQT 190

  Fly   193 HRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLVRRVHSFLERHGFINFGIFKRLK 257
            .:|||.|||..|..|:||||:||:||..|:.|..|::|:..||.|:|.:|||||.||||::||||
Frog   191 QKVFLYIRNRTLQSWLDNPKVQLTFENTLQQLEAPYNSDSVLVHRIHCYLERHGLINFGVYKRLK 255

  Fly   258 PIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTG 322
            |:|.||.||||:||:|:||||.|.|||.|||||.|||||||||||::||||.:|:||:|||||||
Frog   256 PLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTG 320

  Fly   323 VYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYA 387
            :.||||.::|||:.|:|..|:|.||||..:|:.||||||:::|:|||||||:.|||||:||||..
Frog   321 LGGNPMAVISKQVNMELAKIKQKCPLYEANGQGVPKEKDEMVEQEFNRLLEATSYLSHQLDFNIL 385

  Fly   388 GDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMI 452
            .:.|||||.|||.:|.:||..|..::.:|.::|:.||.::.|...::..:::.|.:|..::....
Frog   386 NNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQDELKELLNKMVNVKEKIKELHQQYKEAS 450

  Fly   453 NQRKP---------KGTDGDLKYCYQEFN-IRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQN 507
            ..:.|         |....||....:|:: :..||:|:||                 ||.|||.|
Frog   451 EVKPPRDITAEFLVKSKHRDLTALCKEYDQLAETQVKLEE-----------------KLQELEAN 498

  Fly   508 RPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSCVPVALT 572
            .|||||||||||.|||||||||||||||.|:.||||||||||||||.|.|.|||||||||||||.
Frog   499 PPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALA 563

  Fly   573 ENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNT 637
            |.|||::|:||::::|...|.||:|.|.::::....||.|.|:|||.|||||        ||...
Frog   564 EGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLK--------QQPPA 620

  Fly   638 VKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSISSSP 702
            |:|.||||:||..|::|:||||||||||||||:|||.:.|||||||||||||||:||||::..:|
Frog   621 VQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDSSVNLFGHVGSTTASRGELFLFWNLYKAP 685

  Fly   703 VLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSV 767
            :|||||||.||.::|:::||:|:|||:::||.|||:::|||||||||:|||:|||||||||||:.
Frog   686 ILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAA 750

  Fly   768 GSSGSDYDLLAAPVIP-PSSKDA-EGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYLG 830
            ||||:||||:|.|:.| |:...| :.:|||||||||||||||||||||.||||||||||||.:||
Frog   751 GSSGNDYDLMAQPITPGPAIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLG 815

  Fly   831 YPEGTP 836
            .....|
Frog   816 VMYNLP 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	45/84 (54%)
		NAD_binding_8	269..327	CDD:290186	42/57 (74%)
		Amino_oxidase	274..824	CDD:279874	328/561 (58%)
kdm1a	XP_002936640.1	PLN02328	167..809	CDD:215187	387/666 (58%)
kdm1a	XP_002936640.1	MRPL52	<381..454	CDD:376123	22/72 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	665	1.000	Domainoid score	I149
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32240
Inparanoid	1	1.050	831	1.000	Inparanoid score	I447
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1034142at2759
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	1	1.000	-	-		oto103515
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	1	1.000	-	-		X2101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090