Protein Alignment CG42674 and plekhg5b

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_068073037.2
• Gene: plekhg5b / 796404
• ZFINID: ZDB-GENE-090908-6
• Length: 1125
• Species: Danio rerio
• Alignment Length: 1204
• Identity: 294/1204 - (24%)
• Similarity: 468/1204 - (38%)
• Gaps: 302/1204 - (25%)

  Fly   636 TEKGERTGVCLSPSAPQPSSHASP--HHPPTIYTQAPQVVRRMPSLMLSPTLDETTTTASSSCFG 698
            :.:.|...:|..|..|: ..|||.  |||..      |.:.....|.|..:.|       |.|
Zfish    46 SSQDEECVLCQHPDCPK-RRHASKVCHHPDC------QELNGKSPLHLCESCD-------SRC-- 94

  Fly   699 TGH-PSAGSFHQHQHHHHHHQPTGS-----VSTASCTATSTTSTHAVPSSKHFQSVGEAAATSSS 757
              | ..:.|.|..:|.....||.||     |||.||                      ...||..
Zfish    95 --HLDESDSMHFDRHPRFDVQPQGSILARNVSTRSC----------------------PPRTSPP 135

  Fly   758 STLSPHSATSATLGGGGGGGGAGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSSSEF 822
            |.|......|...|....||                    :|.|  ..:..||....::....|.
Zfish   136 SDLEEDEEASTERGERKAGG--------------------IKLK--VREGNKPRRHHTDNPRREC 178

  Fly   823 FSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPV 887
            ||:.|  |.:...|.|.:||.|..||...|.....|:.:...::.:        |||  .|..|:
Zfish   179 FSLKF--DLNIDIDTEIVPAVKKKTLREVLGPIFERKGIELFRVDL--------FLD--QSNTPL 231

  Fly   888 SVDEQTDVESLAGHHLCITERGSNRKPLQKAASFGSRQPPPRLLPSV---------STEETSESG 943
            |:|  .:.....|.:|.:..|..:...::::.........|.:.|||         :|::...|.
Zfish   232 SLD--FEAFRFGGRYLKVKARPGDELKVEQSVKDLRSLSLPNIKPSVGGSVYILTPATDKPEHSS 294

  Fly   944 V-------------------------------------------APGKQI-----------KQRW 954
            :                                           |||..:           ..|:
Zfish   295 LPRRDSVDILGQARRTKDMKQFLGDASIPSMDTLALLGGSLPPTAPGGSLTAGPNNCKNRPPNRF 359

  Fly   955 SSIFGIKNPQQSQLCELLN----SYAKNGVPQRPDSMSF---------DHPDLVNSLAYLQYMHK 1006
            |..||....::....:|||    :|::.|:|:.|..::|         :.|:|.        :..
Zfish   360 SIFFGAGAEKEVDRVQLLNTKLQAYSQFGLPKLPPQLAFHQDSWEEEEEEPNLT--------LED 416

  Fly  1007 SWRDFVNS-DSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARL 1070
            |||..::. :|:|..:.:.|.|||||:.||..||..|:.:|||||..|..:|:..||.:|:..||
Zfish   417 SWRTLLDDPESLSRRQFQQQEAIWELIQTEATYIKKLRVITDLFLCGLLNLQDNSLLGEVEPTRL 481

  Fly  1071 FSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFY 1135
            |||::.:...:...|...::|.:..:..:...:.....||||.:|||.|.||..||.|:.:|..|
Zfish   482 FSNIQDIVRLHCTLWVQVMFPALEKARGSRSLIEPTDLQEGFSTFASRFQPYIRYCMEEESCMEY 546

  Fly  1136 CKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDV 1200
            .:.|..:|.||..|:.|.|:.|.||||:|||::|:|.||||||.|||..|.|...|....:|::.
Zfish   547 MRSLLRDNELFKIYITWAETNKQCNRLKLADMLVKPHQRLTKYPLLLKTILKKTEDQASRDALNN 611

  Fly  1201 MMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGC 1265
            |:..||.|:..|::.:..|||.::|.....|:|||:.|:..:|.::|.:|:.|:: ||.|||.|.
Zfish   612 MVACVEGFINGVDSQMRQRQEQQKLAATSARVESYEAVEGASEEVEKALKEFSRI-DLTAPMIGT 675

  Fly  1266 PAYHVRHLFMEGDHKFKDNLGKS---DVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIV 1327
            .....|.|.:||..:.|:  ||.   |.:|||.|||||:.|.:.:  |..:||:|||.|...::.
Zfish   676 SPEETRQLHLEGALRMKE--GKDSRMDAYCFLFTDLLLITKPVKR--LEKVKVVRQPLLLHNVVC 736

  Fly  1328 -QLAPNNTLNCVYLNEFQVATTAFTLQCTEA---KNWYDALWRAKTIYQRLK------------- 1375
             :|....:...:|||||:.|..|:|.|...|   |:|.||:...:...|||:
Zfish   737 RELKDPGSFVLIYLNEFKSAVAAYTFQANSAAQGKSWTDAICNVQNQLQRLRSEEARRQKACLKK 801

  Fly  1376 -------------------------RGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSP 1415
                                     :........:.|:...|....|.|.........||....|
Zfish   802 RLLDNQEDEDSCNSTNSSPHLRHKDQSNSQSDGSTETLSVMDMDESGLSLDPSVLQSDLGGHSDP 866

  Fly  1416 ------MNSSICSHVSSANNS------HSGSVE----------WNDSRNISVDFEKTNSVSSDEG 1458
                  .|..:..|::|.:.|      .|.|::          ..:::|.:...::......|:.
Zfish   867 DSAILQQNPELEPHLNSQDASDLDPQYRSMSMDSAYGTLSPESMLETQNPAAPVQEEEKEEEDKE 931

  Fly  1459 SSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMNH---LGQSLPNLNMHHSH 1520
            |:..||:.    :|..:      :.|:.:    ||:::.|||:..:..   :.:.||.|..
Zfish   932 STETTGDE----EGDDE------EDKISV----GSQNSITLSINKLRRQAPVQRRLPFLER---- 978

  Fly  1521 TNNTLLVPGSTTSHSGNMLLSPSHRGISYPPPSPTRVPLRRGMAFSTSTKNPPLRKTRNITSQNS 1585
                 ||   ..|.|.:.|||..|:.|       .:..::....:....|:.....:|::|...:
Zfish   979 -----LV---GKSRSEDNLLSTVHQDI-------PKKKIKSRHTWEQRVKHTEPALSRSLTELKA 1028

  Fly  1586 INWHQIPATPTPPSPRSQYQSPGVVCMQKSLPLLLPTNTDEGQ--------GPTQPPPPL----- 1637
            ....:  :.||..|.|.....|..|.|.......:...|..||        |...||..:
Zfish  1029 AESDE--SLPTEESHRLTCSLPSAVLMDTLKRAKMARETGTGQIPNSSASDGELSPPAGVEGTGN 1091

  Fly  1638 --QKQLSHQ----APL----PTTIHNQSSTETDV 1661
              ||...|:    |.|    .|.:.|.:.|.::|
Zfish  1092 RRQKTQQHKKLTLAQLYKIRTTLVLNSTLTASEV 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	19/77 (25%)
		RhoGEF	1027..1213	CDD:459876	76/185 (41%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	39/101 (39%)
plekhg5b	XP_068073037.2	None