Protein Alignment CG42674 and PLEKHG5

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: NP_001252522.1
• Gene: PLEKHG5 / 57449
• HGNCID: 29105
• Length: 1075
• Species: Homo sapiens
• Alignment Length: 1234
• Identity: 316/1234 - (25%)
• Similarity: 476/1234 - (38%)
• Gaps: 346/1234 - (28%)

  Fly   612 GTGATTGLFATTGAPGSLGRQANVTEKGER-----TGVCLSPSAPQPSSHASPHHPPTIYTQAPQ 671
            |.|.:..|.|:...||...|.:..:..|.|     :.||              ||     ....|
Human     4 GPGVSGRLAASRPGPGLPLRDSEPSWAGGRARDGDSQVC--------------HH-----ADCQQ 49

  Fly   672 VVRRMPSLMLSPTLDETTTTASSSCFGTGHPSAGSFHQHQHHHHHHQ----PTGS-----VSTAS 727
            :.||.| |.|....|                  ..||...|:..|.:    |.||     |||.|
Human    50 LHRRGP-LNLCEACD------------------SKFHSTMHYDGHVRFDLPPQGSVLARNVSTRS 95

  Fly   728 CTATSTTSTHAVPSSKHFQSVGEAAATSSSSTLSPHSATSATLGGGGGGGGAGGGGLTSPVGCST 792
            |                      ...||.:..|......|:..|.|
Human    96 C----------------------PPRTSPAVDLEEEEEESSVDGKG------------------- 119

  Fly   793 SSGSTVKKKSSFMK--RKKPLLTRSEVSSSEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHA 855
                  .:||:.:|  :||.....::..|.|.|::.|  |.:...:.|.:||.|..:|...|...
Human   120 ------DRKSTGLKLSKKKARRRHTDDPSKECFTLKF--DLNVDIETEIVPAMKKKSLGEVLLPV 176

  Fly   856 LRRRNLSFTQITI-TDNNPTPSFL---------------------DAG--------------PSL 884
            ..|:.::..::.| .|.:.||..|                     |.|              |.|
Human   177 FERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPIL 241

  Fly   885 LPVS--------VDEQTDVESLAGHHLCITERGSNRKPLQK---AASFGSRQPPPR---LLPSVS 935
            .|..        ||.|:..|||.     |...|..||.:.:   .||...::||..   .|||.|
Human   242 RPAGTGPPALERVDAQSRRESLD-----ILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGS 301

  Fly   936 TEETSESGVAPGKQIKQRWS---------SIFGIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDH 991
            :..|: :|.:...:...|:|         |.||.:..:..||...|::|:..|:|:.|..:.|||
Human   302 SGSTN-TGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDH 365

  Fly   992 ----------PDLVNSLAYLQYMHKSWRDFVNS-DSMSESEVKIQTAIWELVTTEVYYIHALQTV 1045
                      .|..|:...|:   .|||:.::. :.::..:...|.|:|||:.||..||..|:.:
Human   366 DSWEEEYDEDEDEDNACLRLE---DSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVI 427

  Fly  1046 TDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQE 1110
            .:|||.||..:||.|||.:|:..|||||:..:.:.:.:.|...:.|::..:..|...|:...|.:
Human   428 INLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLK 492

  Fly  1111 GFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRL 1175
            ||..|.|:|.||..||.|:..|..|.:.|..:|.||.:|:.|.|....|.||:|:|::.:|.|||
Human   493 GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 557

  Fly  1176 TKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDT 1240
            |||.|||.::.:...:....||:..|:.|||.|:..||..:..|||.:||..|:.||::|:||::
Human   558 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVES 622

  Fly  1241 NNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNL-GKSDVHCFLLTDLLLVCKT 1304
            :::.:||::|:...: ||.||:.|......|.|.:||..:.|:.. .|.||:|||.||||||.|.
Human   623 SSDEVDKLLKEFLHL-DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKA 686

  Fly  1305 IAKRGLGALKVIRQPYLTDQLIV-QLAPNNTLNCVYLNEFQVATTAFTLQCTE---AKNWYDALW 1365
            :.|  ....:|||.|.|.|:::. :|....:...:|||||..|..|:|.|.:.   .:.|.|.::
Human   687 VKK--AERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIY 749

  Fly  1366 RAKTIYQRLKRGGGGG---------------------------GSGSGTVGGGDSFRFGGSATSG 1403
            .|:...|:|:.....|                           |..|||           ||.|.
Human   750 NAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGT-----------SAASS 803

  Fly  1404 GTADSLGVRKS--PMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEK-TNSVSSDEGSSIMTGN 1465
            .|.    :|||  ..:|..|:...|........||..|:.: |.:|:. ..|..|||.|...|.:
Human   804 PTI----MRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLS-SPEFDSGPFSSQSDETSLSTTAS 863

  Fly  1466 HGVNLKGKQQLISGLHKTKMGIIGQMGSKSAN------TLSVQPMNHLGQSLPNLNMHHSHTNNT 1524
                        |....:::..:|.:..:|.:      |||...:.......|...
Human   864 ------------SATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAE--------- 907

  Fly  1525 LLVPGSTTSHSGNMLLSPSHRGISYPPPSPTRVPLRRGMAFSTSTKNPPLRKTRNITSQNSI--- 1586
             |||           .:|....:..|||||.   |||.......:..|.|.|:::..|...:
Human   908 -LVP-----------RAPESPRVPSPPPSPR---LRRRTPVQLLSCPPHLLKSKSEASLLQLLAG 957

  Fly  1587 -NWHQIP------------ATPTP--------------------PSPRSQYQSPGVV-CMQ---- 1613
             ..|..|            |.|.|                    |||.|   .||:| |:.
Human   958 AGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGS---GPGLVGCLAGEPA 1019

  Fly  1614 -------KSLPLLLPTNTDEGQGP-TQPPPPLQKQLSHQ----APL----PTTIHNQSSTETDV 1661
                   ..||        .|..| .||.||......|:    |.|    .|.:.|.:.|.::|
Human  1020 GSHRKRCGDLP--------SGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	25/121 (21%)
		RhoGEF	1027..1213	CDD:459876	71/185 (38%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	37/99 (37%)
PLEKHG5	NP_001252522.1	RBD_PLEKHG5	143..216	CDD:340588	16/74 (22%)
		RhoGEF	409..596	CDD:214619	72/186 (39%)
		PH_PLEKHG5_G6	652..750	CDD:270064	37/99 (37%)