Protein Alignment CG42674 and plekhg6

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_009290476.2
• Gene: plekhg6 / 563725
• ZFINID: ZDB-GENE-030131-2517
• Length: 1027
• Species: Danio rerio
• Alignment Length: 853
• Identity: 217/853 - (25%)
• Similarity: 347/853 - (40%)
• Gaps: 174/853 - (20%)

  Fly   915 LQKAASFGSRQPPPRLLPSVSTEETSESGVAPGKQIKQRWSSIFGIKNPQQSQLCELLNSYAKNG 979
            :.|.|...||....::|.:..|.:.:.:       :::|...:.|    |...|.:||:|::
Zfish    84 VSKGAGVKSRGALKQVLFNQGTNDKNGT-------VEERLGGVQG----QVDVLKQLLDSFS--- 134

  Fly   980 VPQRPDSMSFDHPDLVNSLAYLQY----------MHKSWRDFVNS-DSMSESEVKIQTAIWELVT 1033
            ||                 |.|::          :.|||.:.|:| :|||:::...|.|:|||:.
Zfish   135 VP-----------------ADLRWTWGEGGTERAVEKSWTEIVHSHESMSKTQRLQQEALWELLN 182

  Fly  1034 TEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAI 1098
            ||:.||:.|....||.||.|......|.|.:|....|||::.::.:|:..||...:|||:....:
Zfish   183 TELTYINKLTIAKDLVLAALSYCHLNGFLQEVSPTMLFSDLPSILDAHRLFWHDVMYPMLQEVRL 247

  Fly  1099 THEPLRCAFFQEGFLSFASIFAPYKIYCAE-QSTCQFYCKELNHNNALFTSYLAWCESQKMCNRL 1162
            |..|......:.|.|.|...|..|..||.| ....:...|:|..|...:| ||.|.|:...|.|:
Zfish   248 TGRPFDPMKLEPGCLQFHKRFPAYFDYCFEGDRNVELTRKQLETNPQFYT-YLMWVENHPQCGRM 311

  Fly  1163 RLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKG 1227
            ||.|:..:|.||:|||.|||.|::|...|:....|:|.|::||.|||.|:|::|.::.:...|..
Zfish   312 RLGDMQAKPHQRITKYPLLLKAVQKTTEDLPAKIALDRMLNSVNNFVQSINDYLQLKADELALSA 376

  Fly  1228 VMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNLGKSDVHC 1292
            :..|||.|.:...:.|| ||.:::..: |||.:||.|.....:|...:|...|.|......:...
Zfish   377 IAQRIEGYKIEGLSEEV-DKHVREICR-FDLTSPMSGVGPNVIRKQILEETLKVKRRKDTKEFVV 439

  Fly  1293 FLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQL-IVQLAPNNTLNCVYLNEF------QVATTAF 1350
            .|.||:||:.|  |::....|||:|.|.|.::: .:::....:...|.:.:.      .:.:|..
Zfish   440 LLFTDVLLITK--AQKKSDKLKVLRPPMLVERIHCIEVKDGYSFMLVEVGDLGCPLSVHIMSTPS 502

  Fly  1351 TLQCTEAKNWYDALWRAKTIYQRLKRGGGGG-GSGSGTVGGGDSFRFGGSATSGGTADSLGVRKS 1414
            ...|.   :|..||...:...|:||...... ...:.||...|: .|..:..|....:.:..:..
Zfish   503 PDSCA---SWVSALRETQEALQKLKINEKNAILKNTHTVPDKDA-DFHTAYYSDIDPEEMVQQIY 563

  Fly  1415 PMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISG 1479
            |.:.| .|....|:|..|...:.:....:.|:..|...: ||..||.:|.....:..|.::::.
Zfish   564 PTSQS-DSDSDPADNERSTFSKVDPHTLMDVEQSKVQQM-SDYRSSSLTEPDDQSQSGYEEVVG- 625

  Fly  1480 LHKT-KMGIIGQMG----------SKSANTLSVQ------------PMNH---LGQSLP---NLN 1515
              || .:|:..:.|          .:.|:..::|            |.|.   ..|.||   |||
Zfish   626 --KTDSVGLNAEQGKSRINSNQWEDEEASLKNIQERRVTWTQKQQTPSNSNDLTQQELPIRNNLN 688

  Fly  1516 MHHSHTNNTLLVPGSTTSHSGN-------MLLSP------SHRG------------------ISY 1549
            ....|..:| :.|..|||..|.       |.|.|      |.|.                  .|.
Zfish   689 GPAGHVKDT-IQPLITTSAHGTSVETGEPMHLDPDSDSQESRRNSLCSQQEDDEESLTESKRFSR 752

  Fly  1550 PPPSPTRVPLRR-------GMAF------STSTKNPP-----LRKTRNITSQNSINWHQIPATPT 1596
            ...|| |:..||       ||.|      |.|.||..     :.|..::.:..|..|: :|...:
Zfish   753 KLKSP-RIQRRRLNNAQPNGMGFASDANSSRSQKNKSQDSHRVLKLGSLKNNPSTLWY-VPEKRS 815

  Fly  1597 PP-SPRSQYQS-------------------------PGVVCMQKSLPLLLPTNTDEGQGPTQPPP 1635
            |. ||..:..|                         |.:...|.|:|....|::.....|...||
Zfish   816 PKRSPTQEMHSEPEQTPEEKRKLKLIKLKTQRSASIPEISIPQTSIPPSQITSSSLLTAPDPQPP 880

  Fly  1636 --PLQKQL 1641
              |||..|
Zfish   881 TSPLQSVL 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130
		RhoGEF	1027..1213	CDD:459876	70/186 (38%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	23/101 (23%)
plekhg6	XP_009290476.2	None