Protein Alignment CG42674 and plekhg5a

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_009304320.2
• Gene: plekhg5a / 562861
• ZFINID: ZDB-GENE-060503-766
• Length: 1157
• Species: Danio rerio
• Alignment Length: 1201
• Identity: 288/1201 - (23%)
• Similarity: 461/1201 - (38%)
• Gaps: 354/1201 - (29%)

  Fly   626 PGSLGRQANVTEKGERTGVCLSPSAPQPSSHASPHHPPTIYTQAPQVVRRMPSLMLSPTLDETTT 690
            ||.|.:..|..|:...:.||..||. |.....||.|
Zfish    50 PGLLCQHPNCPEQRLASKVCHHPSC-QDLRDGSPLH----------------------------- 84

  Fly   691 TASSSCFGTGHPSAGSFHQ----HQHHHHHHQPTGS-----VSTASCTATSTTSTHAVPSSKHFQ 746
             ...||....||:|   |.    .:|.....||.||     |||.||
Zfish    85 -LCESCDSICHPAA---HDGMIFDRHPRFDLQPQGSILARNVSTRSC------------------ 127

  Fly   747 SVGEAAATSSSSTLSPHSATSATLGGGGGGGGAGGGGLTSPVGCSTSSG-STVKKKSSFMKRKKP 810
                          .|.:...:.:..|..|        .|.:|...|.| ..||||:    |::
Zfish   128 --------------PPRTGPPSDMEDGEDG--------CSDLGDRRSGGMKLVKKKT----RRR- 165

  Fly   811 LLTRSEVSSSEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTP 875
               .::..|.|.|::.|  |.:.:...|.:||.|..||...|.....|:.:..:::.:
Zfish   166 ---HTDDPSKECFTLKF--DLNFEVSMEIVPAVKKKTLREVLGAVFERKGIELSRVNL------- 218

  Fly   876 SFLDAGPSLLPVSVDEQTDVESLAGHHL--------------CITERGSNRKPLQKAAS------ 920
             |||  .|..|:|:.  .:.....||:|              |:.:..|...|:.:::|
Zfish   219 -FLD--QSNTPLSLG--FEAYRFGGHYLRVRARPGEDLRVERCVKDPRSLSLPIMRSSSNTHSSS 278

  Fly   921 -----FGS-----------------------------RQPPPRLL--PSVSTEETSE--SGVAPG 947
                 .||                             |:..|..|  .|:|.:::..  ||..||
Zfish   279 TDRAEHGSLGRREAADLLVGLVGHAAYIQKNGGQTRRRKNMPEFLGDSSISNQDSLSQLSGSLPG 343

  Fly   948 ---------KQIKQRWSSIF---------GIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDHPDL 994
                     .:...|:|.:|         |.:..:..||...|.||...|:|:.|..:|| |.|.
Zfish   344 SITGPDRWRNRAASRFSGLFSSNSGNGSLGKECDRVEQLQSKLYSYTMFGLPKMPPQLSF-HRDS 407

  Fly   995 VNSLAYLQYMHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQE 1058
            ......|: :.:||:..: |.:.::..:...|.|||||:.||..||..|..:|||||..|..:||
Zfish   408 WEEEPNLE-LEESWKQLLENPEILTRRQCHQQEAIWELLQTESDYIKKLHVITDLFLCGLLNLQE 471

  Fly  1059 EGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYK 1123
            .|||.:|:..|||||::.:.:.:...||..:.|.:..:......|......:||.:|...|.||.
Zfish   472 SGLLTEVEPTRLFSNIQDIVQLHSSLWTEVMLPALEKARQKKTMLNPTELHQGFSTFGFRFKPYI 536

  Fly  1124 IYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKH 1188
            .||.|:..|..|.:.|..:|.||..|:.|.|:.|.||||:|.|::|:|.||||||.|||.::.|.
Zfish   537 RYCMEEEGCMEYMRTLLKDNELFRIYVTWAETHKQCNRLKLTDMLVKPHQRLTKYPLLLKSVLKK 601

  Fly  1189 MSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNS 1253
            ..|....|||:.|:.:||.|:.||::.:..|:|.::|..:..|||:|:.|:..:|.:::::|:.:
Zfish   602 TDDPPTREAINRMVAAVECFINSVDSQMRHREEKQKLAAIAGRIEAYEAVEGASEEVERILKEYN 666

  Fly  1254 QMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNLGKS---DVHCFLLTDLLLVCKTIAKRGLGALKV 1315
            . |||.||:.|.|....|.|.:||..|.|:  ||.   ||:|||.||:||:.|.:.:  :..:||
Zfish   667 N-FDLMAPVMGAPPEETRQLLLEGALKMKE--GKESRMDVYCFLFTDVLLITKPVKR--VEKVKV 726

  Fly  1316 IRQPYLTDQLIV-QLAPNNTLNCVYLNEFQVATTAFTLQC---TEAKNWYDALWRAKTIYQRLKR 1376
            ||||.:...::. :|....:...:|||||..|..::..|.   .:.::|.:|::.|:...|||:
Zfish   727 IRQPLVIHNVVCRELKDPGSFLLIYLNEFGCAVASYCFQANSGAQGRSWIEAIYNAQNQLQRLR- 790

  Fly  1377 GGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPMNSSICSHVSSANNSHSGSVEWNDSR 1441
                                  |.|....:|.....::.         ||.:.|.|.|:...::.
Zfish   791 ----------------------SETQRDESDEKDEDETE---------SSMSTSSSPSIHHRETL 824

  Fly  1442 NISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMNH 1506
            :.|:....::|..|.|                                        ||||..::.
Zfish   825 SKSLSLSPSHSDGSTE----------------------------------------TLSVAALDE 849

  Fly  1507 LGQSLPNLNMHHSHTNNTLLVPGSTTSHS------GNML---LSPSHRGIS----YPPPSP---- 1554
            :.:.:.:.....|..|:.|.....:||.|      |:::   |.|..|.:|    |...||
Zfish   850 VDEVVGSTVQTASMRNSLLSDDSFSTSDSKTLQALGDLIVTDLDPESRSLSIDSAYGTLSPQSMI 914

  Fly  1555 TRVPLRRGMAFSTSTKNPPLRKTR--------NITSQNSINWH---------------------- 1589
            |.:.|:.|:..|...:.....:..        :....:||.|:
Zfish   915 TELDLKGGVCQSEGEETDAGEEEEAFEDDEDDDDDGDDSITWNGSQITVNESYILDTNSEELNRR 979

  Fly  1590 -------QIPA----------TPTPPSP--------RSQYQSPGVVCMQKSLPLLLPTNTDEGQG 1629
                   |:.|          :|..|.|        ||:.:...:.|:..  ||||.......
Zfish   980 NDFSGMAQVVAGCRSQTLRRRSPVQPRPDYLQHFTLRSRSEDDLLQCLTD--PLLLHRTGKNN-- 1040

  Fly  1630 PTQPPPPLQKQLSHQAPLPTTIHNQSSTETD 1660
                   :.|.|:|.|...:  |:....:||
Zfish  1041 -------ISKSLTHLAKQKS--HSNEVFQTD 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	19/91 (21%)
		RhoGEF	1027..1213	CDD:459876	77/185 (42%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	34/101 (34%)
plekhg5a	XP_009304320.2	None