Protein Alignment CG42674 and plekhg7

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: NP_001315140.1
• Gene: plekhg7 / 562798
• ZFINID: ZDB-GENE-070410-15
• Length: 769
• Species: Danio rerio
• Alignment Length: 832
• Identity: 192/832 - (23%)
• Similarity: 293/832 - (35%)
• Gaps: 236/832 - (28%)

  Fly   620 FATTGAPGSLGRQANVTEKGERTGVCLSPSAPQPSSHASPHHPPTIYTQAPQVVRRMPSLMLSPT 684
            |.:|.:...||   :||     |..|.|........|.  |.|..|  ...|..||||..:.:|.
Zfish    64 FDSTSSGMKLG---SVT-----TSNCTSGDLITQEIHR--HSPAPI--SPSQTQRRMPLPLHTPN 116

  Fly   685 LDETTTTASSSCFGTGHPS--AGSFHQHQHHHHHHQPTGSVSTASCTATSTTSTHAVPSSKHFQS 747
            ...    .|.:|..|. |:  ..|...:....|.|.|| .:|| |.|.....||...  ::...:
Zfish   117 FHR----HSPACCSTS-PALWRSSGMSYSVDFHRHSPT-RIST-SPTLRRMRSTRIY--NRETSN 172

  Fly   748 VGEAAATSSSSTLSPHSATSATLGGGGGGGGAGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLL 812
            ..:.....||:.:|||                                      |||.:.|.||.
Zfish   173 PAKPLREESSTPMSPH--------------------------------------SSFFREKSPLA 199

  Fly   813 TRSEVSSSEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSF 877
            ...|               ::.|:....|.|       ..:|  |.:.|        ||......
Zfish   200 ADEE---------------NKSPESSVTPGT-------VRTH--RSQTL--------DNGSICKS 232

  Fly   878 LDAGPSLLPVSVDEQT--DVESLAGHHLCITERGSNRKPLQKAASFGSRQPPPRLLPSVSTEETS 940
            .::..|..|.|..|.|  |.|.:             :.|..|......|......||.:.
Zfish   233 KESCDSKKPASDKESTTDDNEQV-------------KDPCHKRLKERRRSSVVVSLPGLD----- 279

  Fly   941 ESGVAPGKQIKQRWSSIFGIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDH------------PD 993
               |:||        .:| :.|    ...::||   |:...::.....|..            .|
Zfish   280 ---VSPG--------DLF-VSN----GAADMLN---KSDYSEKKSKWPFSRRSTQTKVKTRSGAD 325

  Fly   994 LVNSLAYLQYMHKSWR--DFVNSDSMS-------ESEV---------KIQTAIWELVTTE-VYYI 1039
            :...||.:|.  ..||  ||.....||       .||:         |.|.|||||.|:| ||::
Zfish   326 IDKCLASVQV--PEWRDTDFQTFKDMSLVDFLQGRSELKAAQHPMTYKTQEAIWELFTSECVYFL 388

  Fly  1040 HALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWT--------LWLYPMVAHS 1096
            ..|..:.::||..|..:|....|.|:|..|||:|:..:|..:..|.|        :|..|....:
Zfish   389 DQLMVLKEVFLTTLSDLQTRQCLQDIDSWRLFANLNELCLVSFGFLTSLLRVIKEMWTDPDSCST 453

  Fly  1097 AITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNR 1161
            ...|:..|.||.:       ||....:.||...||...|...|..... |.|::.|||..:.|.|
Zfish   454 QSLHDLFRKAFSE-------SICHCLQKYCLNYSTAILYLDSLKLRED-FGSFVKWCERNEECRR 510

  Fly  1162 LRLADIVVRPMQRLTKYSLLLAAI-KKHMSDVEE------IEAIDVMMHSVENFVGSVNNHLTMR 1219
            |:|.|::|.|:||.|:|.|||..| |:..|..||      ::.:|..::.:|..|..::|:
Zfish   511 LQLKDLLVVPLQRFTRYPLLLKNIGKRSCSKAEENTIQSIVDLVDRAIYDLEGKVKWLDNY---- 571

  Fly  1220 QENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDN 1284
            |:.::||..:|.:..::        .||.......:..|..|:........|.|..:|.....:|
Zfish   572 QKVKQLKETLVWLPVWE--------SDKRAHVPESLKHLLKPVTLENLVINRSLLHDGKLFLIEN 628

  Fly  1285 LGKSDVHCFLLTDLLLVCK---------------------TIAKRGLGALKVIRQPYLTDQL--- 1325
            ..:.:|:.||..:.||:.|                     .:.:.|. :..|:.||...|:|
Zfish   629 TKQQEVYLFLFDEFLLITKIKRNKKQKSGVVDFAAGQELELLLQEGC-SFTVLDQPISLDRLQLK 692

  Fly  1326 -IVQL------APNNTLNCVYLNEFQVATTAFTLQC---TEAKNWYDALWRA 1367
             |.||      .||:.: .::.|.:|.....|.||.   :..|.|...:.:|
Zfish   693 NIDQLNATASTLPNSFI-IMHQNRYQQCIAVFVLQAQSESTKKAWMSEIEKA 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	15/79 (19%)
		RhoGEF	1027..1213	CDD:459876	65/201 (32%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	28/128 (22%)
plekhg7	NP_001315140.1	RhoGEF	375..538	CDD:214619	59/170 (35%)
		PH_PLEKHG7	616..741	CDD:270065	27/126 (21%)