Protein Alignment CG42674 and arhgef3l

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_005162130.1
• Gene: arhgef3l / 553761
• ZFINID: ZDB-GENE-050522-85
• Length: 532
• Species: Danio rerio
• Alignment Length: 579
• Identity: 118/579 - (20%)
• Similarity: 199/579 - (34%)
• Gaps: 140/579 - (24%)

  Fly   836 DEEFIPATKGVTLLNALSHALRRRNLSFTQITITD-----NNPTPSFLDAGPSLLPVSVDEQTDV 895
            :|:..|....|.|.::.|...|.|.|  |...::|     ....|| .||..|...:...|:.|.
Zfish     3 EEKMEPEETEVDLSSSWSPITRERLL--TCANLSDFAGKKRKQDPS-SDAENSARILEDCEEDDF 64

  Fly   896 ESLAGHHLCITERGSNR--KPLQKAASFGSRQPP------PRLLPSVSTE---ETSESGVAPGKQ 949
            .  ...|:..:|...|:  ||:.|.||......|      .||..|:...   .|....:.|..:
Zfish    65 P--ISDHMQDSEGPCNKRVKPVDKGASVTGIITPVKTPALKRLGQSIQRSISFRTEARPLPPMPR 127

  Fly   950 IKQRWSSIFGIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFVN- 1013
            .:|:.||.                       |:|..|                   :.|.|.|:
Zfish   128 SRQKASSF-----------------------PRRRSS-------------------QLWSDTVDN 150

  Fly  1014 -SDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAV 1077
             |..:|..|:|.|..|:||...|...|..|..|..::   .|.:.:..::.:.:..::|..:.:
Zfish   151 MSHELSTKEIKRQEVIYELTQGEKQLIEDLSLVKKVY---YEPMLKLDIMTESELGQIFGTLDS- 211

  Fly  1078 CEANIKFWTLWLYPMVAHSAITHEPLRCA--FFQE---GFLSFASIFAPYKIYCAEQSTCQFYCK 1137
                       |.|:.....:..|.||.|  ..||   ..:.:......|..||..|...:....
Zfish   212 -----------LIPLHEDLLVRLEGLRGAEKTVQEVGPTMMDWFPCLEAYITYCCNQVGAKALLD 265

  Fly  1138 ELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMS-DVEEIEAIDVM 1201
            :...:..: ..:|..|:......:|.|.:.:..|..||.||.|||..|:|... |..:.:|:...
Zfish   266 QKKQDKRV-EQFLRLCQESSFSRKLDLWNFLDLPRSRLVKYPLLLKEIQKSTPLDHPDEDALPQA 329

  Fly  1202 MHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCP 1266
            |..::..:..||......:.....:|:....:|..|.:....
Zfish   330 MELIQRIITEVNLKTGEAECQFYRRGLCYAEDSQRVAEIQAS----------------------- 371

  Fly  1267 AYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIA--KRGLGALKVIRQPYLTDQLIVQL 1329
                |.|:..|:  .|...|:. :|.||...:|::.:.:|  :.|....:|.|||.....|.::.
Zfish   372 ----RFLYCHGE--LKSTKGQK-LHVFLFELVLVLTRPVAQDREGPVQFQVYRQPMPAAHLHLED 429

  Fly  1330 APNN------------TLNCVYLNEFQVATT------AFTLQCTEAKN---WYDALWRA 1367
            .|:.            |.|....|.|:|:||      :.:||..::.|   |...|.:|
Zfish   430 LPDGEPSSSGSFRGAFTGNDKVKNCFRVSTTGRSKSQSHSLQANDSFNKQQWISCLRQA 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	18/76 (24%)
		RhoGEF	1027..1213	CDD:459876	38/191 (20%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	29/117 (25%)
arhgef3l	XP_005162130.1	RhoGEF	165..341	CDD:459876	38/191 (20%)
		PH_RhoGEF3_XPLN	355..489	CDD:269976	33/164 (20%)