Protein Alignment CG42674 and PLEKHG7

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_047284823.1
• Gene: PLEKHG7 / 440107
• HGNCID: 33829
• Length: 765
• Species: Homo sapiens
• Alignment Length: 822
• Identity: 179/822 - (21%)
• Similarity: 282/822 - (34%)
• Gaps: 251/822 - (30%)

  Fly   657 ASPHHPP---------TIYTQAPQVVRRMPSLMLSPTLDETTTTASSSCFGTGHPSAGSFHQHQH 712
            |...|||         ..:...|.|   .|...:..|...........|..:..||..|..::|.
Human    45 AEIEHPPCDPENSNSYVFWNLLPTV---EPLSFMEKTESFCPEVPPQDCGASPRPSLRSLPKNQG 106

  Fly   713 H--HHHHQPTGSVSTASCTATSTTSTHAVPSSKHFQSVGEAAATSSSSTLSPHSATSATLGGGGG 775
            .  ....|..|.:||:             |:.:..::.|..         :...|...|..|..|
Human   107 SLLQFDRQAPGRISTS-------------PTLRRLRTRGCG---------TRQDAWQVTTWGSWG 149

  Fly   776 GGGAGGGGLTSPVG--C--STSSGSTVKKKSSFMKRKKPLLTRSEVSS--SEFFSVSFCLDSSQQ 834
                      :|||  |  |.|...:.|..|..:   .||...|.::|  ....:.:..|:...:
Human   150 ----------APVGFPCYLSKSLPGSPKDSSHLL---SPLRLHSRLTSEPERALNAADSLEPQTR 201

  Fly   835 PDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVD--EQTDVES 897
            |.::::|                                        |.|.||:..  .|..:..
Human   202 PTDKYLP----------------------------------------PELQPVNEGSLHQASLRQ 226

  Fly   898 LAGHHLCITERGSNRKPLQKAASFGSRQPPPRLL-PSVSTEETSESGVAPGKQIKQRWSSI---- 957
            ..||.|                      |.|.|. ||...||     :.|.:..:.|.||:
Human   227 QEGHFL----------------------PSPTLRHPSPQGEE-----LHPSRFYEHRRSSVVLNL 264

  Fly   958 ---------FGIKNPQQSQLCE---LLNSYAKNGVPQRPDSM------SFDH-PDLVNSLAYLQY 1003
                     ..:.:.....||.   ||||.:|.  |:.|.|.      ...| .||.|.|:.::.
Human   265 PGLEVFPGDLLVSDGAADYLCHPLLLLNSESKK--PRWPFSKRGVGKDKHKHISDLENCLSSVKI 327

  Fly  1004 MHKSWRDFVNSDSMSESEV---------------KIQTAIWELVTTE-VYYIHALQTVTDLFLAC 1052
            ......||......:..||               |.|.|:|||.|:| .|::..|..:..:|:..
Human   328 TSFRGYDFYGLKDKTWDEVLETHHKLPTDQLDLKKQQEAVWELFTSECTYFLDHLLVLKMIFMNT 392

  Fly  1053 LEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFAS 1117
            |..:|....|:|||..|||:|:..:.:.::.|... |:.::.......|       ....|.|.|
Human   393 LRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNS-LFGIIKDYVDASE-------ISSSLDFIS 449

  Fly  1118 IFAPY---------KIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQ 1173
            :...|         :.||...|...||.:.|...:. |..||.|||..:.|.||.:.:::|.|:|
Human   450 VLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQ 513

  Fly  1174 RLTKYSLLLAAI-KKHMSDVEEI------EAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMV- 1230
            |||:|.|||..| |:.|...|:|      |.::..:..:|..|..::|.    |:...|:.::|
Human   514 RLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNF----QKFRYLQEIIVW 574

  Fly  1231 -----RIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNLGKSDV 1290
                 |.:.:.:.:....:..:.:.:|     :.:|..       |||..||.....::....||
Human   575 PPLWDRDKRFFIPECLKHIFKEHMAEN-----ILSPTS-------RHLLYEGKLTLAESTRFLDV 627

  Fly  1291 HCFLLTDLLLVCKT-------------------------IAKRGLGALKVIRQPYLTDQLIVQ-L 1329
            :.||..|.|||.||                         :.|.| |:..|:.||...|:|:|: :
Human   628 YLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEG-GSCTVLDQPIPLDRLVVKSI 691

  Fly  1330 AP--------NNTLNCVYLNEFQVATTAFTLQC-TE--AKNW 1360
            .|        .|.....:.|.::....||.||. ||  .|.|
Human   692 EPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTW 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	10/79 (13%)
		RhoGEF	1027..1213	CDD:459876	59/202 (29%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	35/127 (28%)
PLEKHG7	XP_047284823.1	DUF4675	76..252	CDD:464824	47/277 (17%)
		RhoGEF	366..550	CDD:214619	57/192 (30%)
		PH_PLEKHG7	609..737	CDD:270065	34/126 (27%)