Protein Alignment CG42674 and Plekhg5

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_006538986.1
• Gene: Plekhg5 / 269608
• MGIID: 2652860
• Length: 1103
• Species: Mus musculus
• Alignment Length: 1198
• Identity: 315/1198 - (26%)
• Similarity: 469/1198 - (39%)
• Gaps: 332/1198 - (27%)

  Fly   618 GLFATTGAPGSLGR------------------------QANVTEKGERTGVCLSPSAPQPSSHAS 658
            |.:.....||.||:                        |:...|||.|   |.:|:.......|.
Mouse     9 GAYELEALPGDLGQLELGAVERFSWSSALDIIEDLGEDQSPAEEKGLR---CQNPACMDKGRAAK 70

  Fly   659 PHHPPTIYTQAPQVVRRMPSLMLSPTLDETTTTASSSCFGTGHPSAGSFHQHQHHHHHHQ----P 719
            ..|    :....|:..|.| |.|..|.|                  ..||...|:..|.:    |
Mouse    71 VCH----HADCQQLHHRGP-LNLCETCD------------------SKFHSTLHYDGHVRFDLPP 112

  Fly   720 TGS-----VSTASCTATSTTSTHAVPSSKHFQSVGEAAATSSSSTLSPHSATSATLGGGGGGGGA 779
            .||     |||.||                                .|.::.:|.|.
Mouse   113 QGSVLARNVSTRSC--------------------------------PPRTSPAADLE-------- 137

  Fly   780 GGGGLTSPVGCSTSSGSTVKKKSSFMK--RKKPLLTRSEVSSSEFFSVSFCLDSSQQPDEEFIPA 842
                 ....||:...|.   :||:.:|  :||.....::..|.|.|::.|  |.:...:.|.:||
Mouse   138 -----EEEEGCTDGKGD---RKSAGLKISKKKARRRHTDDPSKECFTLKF--DLNVDIETEIVPA 192

  Fly   843 TKGVTLLNALSHALRRRNLSFTQITI-TDNNPTPSFL-------------------DAG------ 881
            .|..:|...|.....|:.::..::.| .|.:.||..|                   |.|
Mouse   193 MKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGV 257

  Fly   882 --------PSLLPVS----VDEQTDVESLAGHHLCITERGSNRKPLQK---AASFGSRQPPPRLL 931
                    |:|.|..    |.|:.|.:|.....|.|...|..||.:.:   .|.....:||..
Mouse   258 KDSKSLSLPALRPSGAGPPVSERVDPQSRRESSLDILAPGRRRKNMSEFLGEAGIPGHEPPAP-- 320

  Fly   932 PSVSTEETSESGVAPGKQIKQRW-----------------SSIFGIKNPQQSQLCELLNSYAKNG 979
            .|.|....|..|.:.|  |.:.|                 :|.|..:..:..||...|::|:..|
Mouse   321 SSCSLPVGSSGGTSSG--INESWKNRAASRFSGFFSSSPSTSAFSREVDKMEQLESKLHAYSLFG 383

  Fly   980 VPQRPDSMSFDH-----------PDLVNSLAYLQYMHKSWRDFVNS-DSMSESEVKIQTAIWELV 1032
            :|:.|..:.|||           .|..:|...|:   .|||:..:. :.::..:...|.|:|||:
Mouse   384 LPRMPRRLRFDHDSWEEEEEDDEEDEESSGLRLE---DSWRELTDGHEKLTRRQCHQQEAVWELL 445

  Fly  1033 TTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSA 1097
            .|||.||..|:.:|:|||.||..:||.|||.:|:..|||||:..:.:.:...|...:.|::..:.
Mouse   446 HTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKAR 510

  Fly  1098 ITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRL 1162
            .|...|:.:.|.:||..|.|:|.||..||.|:..|..|.:.|..:|.||.:|:.|.|..:.|.||
Mouse   511 RTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRL 575

  Fly  1163 RLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKG 1227
            :|:|::.:|.||||||.|||.::.:...|....|||..|:.|||.|:..||..:..|||.:||.|
Mouse   576 KLSDMLAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCMRQRQERQRLAG 640

  Fly  1228 VMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNL-GKSDVH 1291
            |:.||::|:||:.:|:.:||::|:...: ||.|||.|......|.|.:||..:.|:.. .|.||:
Mouse   641 VVSRIDAYEVVEGSNDEVDKLLKEFLHL-DLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVY 704

  Fly  1292 CFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIV-QLAPNNTLNCVYLNEFQVATTAFTLQCT 1355
            |||.||||||.|.:.|  ....||||.|.|.|:::. :|....:...:|||||..|..|:|.|.:
Mouse   705 CFLFTDLLLVTKAVKK--AERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQAS 767

  Fly  1356 E---AKNWYDALWRAKTIYQRLK-----RGGGGG----------------GSGSGTVGGGDSFRF 1396
            .   .::|.|.::.|:...|:|:     :...|.                |..|||
Mouse   768 SQALCRSWVDTIYNAQNQLQQLRAQLSAQEHPGSQHLQSLEEEEDEQEEEGEESGT--------- 823

  Fly  1397 GGSATSGGTADSLGVRKSPMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEKTNSVSSDEGSSI 1461
              ||.|..|.    :|||                           :.|:|.|...|..|.|..::
Mouse   824 --SAASSPTI----LRKS---------------------------SNSLDSEHCTSDGSTETLAM 855

  Fly  1462 MTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKS-ANTLSVQPMNHLGQSLPNLNMHHSHTNNTL 1525
            :....|..|...:  ..|         |.:.|:| .::||              |...|.|..:.
Mouse   856 VVVEPGATLSSPE--FEG---------GPVSSQSDESSLS--------------NTASSVTPTSE 895

  Fly  1526 LVP-GSTTSHSGNM-----LLSPS--------HRGISYPP----PSPTRVP-LRRGMAFSTSTKN 1571
            |:| |.....|.:|     .|||:        |..:...|    |||...| |||........:.
Mouse   896 LLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPHPVVEPAPVPQTPSPQPSPRLRRRTPVQLLPRP 960

  Fly  1572 PPLRKTRNITSQNSINWHQIPATP----TPPSP-RSQYQ------SPGVVCMQKSLPLLLPTNTD 1625
            |.|.|:::..|...:    :..||    .||:| ||..:      :|||   :...||      .
Mouse   961 PRLLKSKSEASLLQL----LSGTPAARGVPPAPSRSLSELCLISVAPGV---RTQRPL------Q 1012

  Fly  1626 EG----QGPTQPPPPLQKQLSHQAPLPT 1649
            ||    .||....|....|||.....|:
Mouse  1013 EGGPGWNGPGMCDPCHGPQLSESENRPS 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	24/115 (21%)
		RhoGEF	1027..1213	CDD:459876	75/185 (41%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	38/99 (38%)
Plekhg5	XP_006538986.1	RBD_PLEKHG5	172..246	CDD:340588	16/75 (21%)
		RhoGEF	440..626	CDD:214619	75/185 (41%)
		PH_PLEKHG5_G6	683..781	CDD:270064	38/99 (38%)