Protein Alignment CG42674 and Plekhg6

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: NP_941006.2
• Gene: Plekhg6 / 213522
• MGIID: 2682298
• Length: 787
• Species: Mus musculus
• Alignment Length: 804
• Identity: 216/804 - (26%)
• Similarity: 336/804 - (41%)
• Gaps: 163/804 - (20%)

  Fly   892 QTDVESLAGHHLCITERGS-----NRKPLQKAASFGSRQPPPR-LLPSVSTEETSESGVAPGKQI 950
            ||...|.||:   :..||.     :|:.||....|.......| :.|.|..|...|
Mouse    28 QTSAHSTAGN---LFPRGGPGVDPSRRRLQHYVPFAKGSGQTRGMSPLVLREPDPE--------- 80

  Fly   951 KQRWSSIFGIKNPQQSQLCEL---------LNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHK 1006
             :|..|.||:..|...:|.|:         |::::..|:|:.|.. ...|.::.........|.|
Mouse    81 -KRHGSYFGVGPPHSPKLKEVTRAHELEIRLHTFSMFGMPRLPPE-DRRHWEIGEGGDSALTMEK 143

  Fly  1007 SWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARL 1070
            ||::.| ....|:......|.|:|||:|||:.|:..|:.:|||..|.|..:|..|||.:|....|
Mouse   144 SWKELVLEHKEMNRQLCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEVSAETL 208

  Fly  1071 FSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFY 1135
            |.||..:..|:.:||...|.|::..:..:.:||.....|.|||:|...|.||..||........|
Mouse   209 FGNVPNLIRAHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYVQYCLRVKQTMAY 273

  Fly  1136 CKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDV 1200
            .:|....|.||.:::.|||..|...|..|.|::::|.||:|||.|||.|::|...:....||::.
Mouse   274 AREQQDTNPLFHTFVQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVRKRSPEPRAQEALNA 338

  Fly  1201 MMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGC 1265
            |:.:||:|:..:|..:...:|.|.|..|..||..|:|::.::|.::|.::..|.: ||..|:.|.
Mouse   339 MIEAVESFLRHINGQVRQGEEQESLMAVAQRIGPYEVLEPSSEEVEKNLRPFSTL-DLMTPVLGV 402

  Fly  1266 PAYHVRHLFMEGDHKFKDNL-GKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQ- 1328
            ...:.|.|.:||..:.|:.. ||.||:.||.:|:|||.|  .:|.....||||.|.:.::|:.:
Mouse   403 APEYTRQLLLEGPVRVKEGREGKMDVYLFLFSDVLLVTK--PQRKADRAKVIRPPLMLEKLVCRP 465

  Fly  1329 LAPNNTLNCVYLNEFQVATTAFTLQC---TEAKNWYDALWRAKTIYQRLKRGGGGGGSGSGTVGG 1390
            |...|:...::|.|||..::|.|:.|   ||...|.:....|:|..|:||
Mouse   466 LRDPNSFLLIHLTEFQCVSSALTVHCPSSTERARWLEKTQHAQTTLQKLK--------------- 515

  Fly  1391 GDSF-----RFGGSATSGGTADSLGVRKSPMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEKT 1450
            |:.:     .......:.||       :||         |:..::.|.|.|
Mouse   516 GEQYIQQKRELLALYRNQGT-------ESP---------STRPSTPSPSPE-------------- 550

  Fly  1451 NSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMNHLGQSLPNLN 1515
            :|.||.||.::                      :..||                       |.|.
Mouse   551 DSQSSAEGRTL----------------------EFAII-----------------------PRLV 570

  Fly  1516 MHHSHTNNTLLVPGSTTSHSGNMLLSPSHRGISYPPPSPTRVPLRRGMAFSTSTKNPPLRKTRNI 1580
            :......:|..:| ...|.||...|.||       .|..:..||.|       .::..||:...:
Mouse   571 VTEDTDEDTPSMP-DDASDSGYGTLIPS-------SPKDSHSPLNR-------LRSKALRRDPRL 620

  Fly  1581 TSQNSINWHQIPATPTPPSP-----RSQYQSPGVVCMQKSLPLLLPTNTDEGQGPTQPPPPLQKQ 1640
            |. :::....:|..|.||.|     ||..:.|..:....|||...|....|.:..|.....:..:
Mouse   621 TF-STLELRDVPLRPQPPDPQAPQRRSAPELPEGILRGGSLPRRAPPIWSEEEDETLASGNVVVE 684

  Fly  1641 LSHQA----PLPTTIHNQSSTETD 1660
            ..|:|    |||     .|.|.||
Mouse   685 TLHRAQRRSPLP-----HSPTHTD 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	5/15 (33%)
		RhoGEF	1027..1213	CDD:459876	69/185 (37%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	35/99 (35%)
Plekhg6	NP_941006.2	RhoGEF	165..351	CDD:459876	69/185 (37%)
		PH_PLEKHG5_G6	408..505	CDD:270064	35/98 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	533..762		55/267 (21%)