Protein Alignment CG42674 and prhg-1

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: NP_001122556.1
• Gene: prhg-1 / 190810
• WormBaseID: WBGene00022391
• Length: 628
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 119/570 - (20%)
• Similarity: 211/570 - (37%)
• Gaps: 128/570 - (22%)

  Fly   901 HHLCITERGS----------------NRKPLQKAASFGSRQPPPRLLPSVSTEETSESG------ 943
            ||:    ||:                |::.|.:..:....||.       ..:|||..|
 Worm    12 HHI----RGNQLIKPPEEGEPQTIHPNKEQLSRRHAIIPDQPS-------ENQETSSQGCCSSDN 65

  Fly   944 --VAPGKQIKQRWSSIFG----------------------------------IKNPQQSQLCELL 972
              :.|..||....|.:|.                                  ...||:::...:|
 Worm    66 VIIVPHVQISPNESHLFNRAISSGGGLLADSNKITSIDLQRATIASQAFYAEASEPQKNRSPWIL 130

  Fly   973 NS-YAKNGVPQRPD---------SMSFDH---PDLVNSLAYLQYMHKSWRDFVNSDSMSESEVKI 1024
            .. |..:|..:|.:         ..|.||   .|.:..|..:.:......|  .:.::..|:.|.
 Worm   131 KRLYEWSGRAKRREIIKHVQAALETSKDHEIEDDELEKLLPVSFEEMFMGD--ETTTIPSSKHKY 193

  Fly  1025 QTAIWELVTTEVYYIH-ALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLW 1088
            ..|:|||..||:.::: .|..:.|::...|:..|.||.|:.|:...||.|:..:|..:..|...:
 Worm   194 LQAVWELFHTELVFLYRQLFVLRDVYKEPLKRCQVEGCLLLVEPDLLFGNLDQLCRISRTFCQSF 258

  Fly  1089 LYPMVAHSAITHEPLRCA-----FFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTS 1148
            |..:   |.:..|...|.     .| |.|....|..:.|:.||........|...:......||.
 Worm   259 LSLL---STVDKENWDCTQLVVDLF-ERFSKGPSTISAYQAYCINYKATMEYLGSIRQKEERFTE 319

  Fly  1149 YLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVN 1213
            :...|.:.:.|.||:|.|:::.|:||:|:..:||..|.|...:.|....::.::.::...:.|::
 Worm   320 FERICLADERCFRLQLEDLLIAPLQRITRLPILLREIHKRSEEEESKGKVEKVIDTMTESLRSID 384

  Fly  1214 NHLTMRQENERLKGVMVRIESYDVVD--TNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFME 1276
            :.:......|||:.:..::...::.|  ..:.|.|.:....|:.|  |..:...|.   |.|..|
 Worm   385 DSVQWLHNFERLQQLQTQVVWPNISDLEPKSYVPDFLRVALSRQF--CENLLAHPR---RKLIHE 444

  Fly  1277 GDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPY-LTDQLIVQLAPNNTLNCVY- 1339
            |..:..:|....|::.||..|:.::.||  |:....|||...|. .::..|||..|....:||:
 Worm   445 GPLELVENGRTVDMYAFLFNDMFVLTKT--KKCASKLKVKGVPIGKSEHYIVQRQPVPLDSCVFC 507

  Fly  1340 ---------------------LNEFQVATTAFTLQCTEAKNWYDALWRAK 1368
                                 |..:......:|||..:..:  ..||..|
 Worm   508 DADSNDQATPMSLKFAFVIIHLTRYYQVVGIYTLQAADKAD--KELWIEK 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	2/6 (33%)
		RhoGEF	1027..1213	CDD:459876	49/191 (26%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	27/117 (23%)
prhg-1	NP_001122556.1	RhoGEF	196..385	CDD:214619	49/192 (26%)
		PH_PLEKHG7	440..557	CDD:270065	28/120 (23%)