Protein Alignment CG42674 and rhgf-2

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: NP_001368191.1
• Gene: rhgf-2 / 173748
• WormBaseID: WBGene00006476
• Length: 1149
• Species: Caenorhabditis elegans
• Alignment Length: 1248
• Identity: 277/1248 - (22%)
• Similarity: 449/1248 - (35%)
• Gaps: 287/1248 - (22%)

  Fly   584 LDSGVVACQQGPPGMATSTASTTATTAGGTGATTGLFATTGAPGSLGRQANVTEKGERTGVCLSP 648
            |::|........|...||:...:|......|||| |.|.|..|.:.....::.|:         |
 Worm     2 LENGSATPSTSIPCTFTSSEPLSAMRLCYNGATT-LLAATACPAAFVDLDSIREE---------P 56

  Fly   649 SAPQPSSHASPHHPPTIYTQAPQVVRRMPSLMLSPTLDE-----TTTTASSSCF--GTGHPSAGS 706
            .:|:|..     ...:::      .|...|.:.|| |||     |::|:|...|  .........
 Worm    57 PSPRPLD-----RDDSVF------FRESCSTIGSP-LDELPALPTSSTSSPFKFMESIQRKRKSM 109

  Fly   707 FHQHQHHHHHHQPTGSVSTASCTATSTTSTHAVPSS--KHFQSVGEAAATSSS---STLSPHSAT 766
            |.::|      ..:..::|.....|...|..::|.:  :...|||.|.:...|   ...:.|:..
 Worm   110 FRRNQ------SSSNLINTEKRRTTRRPSLPSIPPTIDEMSSSVGHARSRRPSLHNDWTNEHAQR 168

  Fly   767 SATLGGGGGGGGAGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSSSEFFSVSFCLDS 831
            :|                             :..:...:....|.:       :.|.:|...||.
 Worm   169 NA-----------------------------LDNRIHHIDIDPPQI-------NYFIAVFKDLDD 197

  Fly   832 SQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQTDVE 896
            .::...|.|.......:.......||.|.|:.        |....||:...:.:|    |.:...
 Worm   198 REKDSVEHIRFDCNQLIYEVFEPFLRIRGLTI--------NDVEFFLEKSSTPIP----ENSGAR 250

  Fly   897 SLAGHHLCITERGSNRKPLQKAASFGSRQPPPRLLPSVSTEETSESGVAPGKQIKQRWSSIFGIK 961
            .|||..:.:..||:.:......|:....:...|....:|.|..|........:|..|.|......
 Worm   251 FLAGQRIFVRGRGNMKVVRHTRATHSMDESNERATRKMSAEAVSRKSSFVNSRILNRGSRNHPGL 315

  Fly   962 NPQQSQLCELLNSYAKNGVPQRPDSMSFDHPD--------------------------------- 993
            |......|...:|    .:..| ||..:|.|.
 Worm   316 NGSDDAECRSNDS----SLSVR-DSWQYDEPSCSEVPDDGGTRRARSVTSSRISLFFGKETGKIE 375

  Fly   994 -----LVN------SLAYLQY-MHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTV 1045
                 ::|      .|.|..| :.|.||:.| |.:|:|:..:|.|.||||:||||..||..|:.:
 Worm   376 KEMFRILNQKKEDTDLEYPTYKLEKDWREIVHNHESLSDKSIKQQEAIWEIVTTEFRYIKLLRYL 440

  Fly  1046 TDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLY---PMVAHSAITHEPLRCAF 1107
            ::|.. .|..:|..|.|.|::...:|.|.  |...|:.:.:|||.   |::|.|..|.|||...:
 Worm   441 SNLSF-YLTDLQNCGFLKDIENRLVFFNF--VTLFNVNYDSLWLQSIEPILAKSRETGEPLDVNY 502

  Fly  1108 FQEGFLSFASIFAPY-KIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRP 1171
            .|.||....:....| ..:.|...:.:...|:|..:.. |..::.|.|:|:..:|.:|.|....|
 Worm   503 LQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESEN-FRDFVTWAEAQENLDRQKLIDTFSVP 566

  Fly  1172 MQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYD 1236
            |||||:|:|||.|:.|..:|..|.|.|..::...|:....:|..|........|..||..||..|
 Worm   567 MQRLTRYNLLLKAVLKVTTDENEREMISNLVDCAESATAQLNKELNNNDLRAMLGDVMRTIEGPD 631

  Fly  1237 VVDTNNEVLDKMIKQNSQMFDLCAPMR---GCPAYHVRH-----LFMEGDHKFKDNL--GKSDVH 1291
            .||.:         :..::|:|..|:.   ..|..|.|.     |...||.:.::..  .|:|||
 Worm   632 YVDQD---------ELERLFNLKLPLNLGDFMPLLHPRKPTHRTLIYRGDLRMQEGKKGSKADVH 687

  Fly  1292 CFLLTDLLLVCKTIAKRGLGALKVIRQP-YLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCT 1355
            |.:.||:.|:|:.:..: ...||:::.| ::...:....|..|....|:|.:|..|...:::..:
 Worm   688 CIIFTDMFLICRKVQGK-KDRLKILKPPIHMGKMMFHYFADQNGFYLVHLTDFHTAQALYSMHTS 751

  Fly  1356 ---EAKNWYDALWRAKTIYQRLKRGGGGGGS---------GSGTVGGGDSFRFGGSATSGGTADS 1408
               :...|.|.|..|...::::.|......:         |.|.:....||........|.....
 Worm   752 GPEDTLRWTDMLKMALDEFKKIHRDSWSQQNQQESPLDEYGRGFIMEPSSFYSQRMLPPGYAQQQ 816

  Fly  1409 LGV--RK-SPMNSSICS--------HVSSANNS------HSG--SVEWNDSRN-ISVDFEKTNSV 1453
            :.|  || |.|:|...:        |.|||.:|      |||  |::.:..|: :||.....|.:
 Worm   817 MPVIHRKCSSMDSQAVAAHAHLNYMHRSSAVSSTEQLDRHSGTDSMKCSPPRHKLSVASCHANPL 881

  Fly  1454 SSDEGSSIM-----------------TGNHGVNLKGKQQ--LISGLHKTKMGIIGQMGSKSANTL 1499
            ||.:.|..:                 :.:.|..::|.:|  ..|...:.::|...|:||...||.
 Worm   882 SSSKSSVDLYVSLGAENGDIERPRSRSNSSGPEIEGLKQRSRSSSPDQKELGTPAQIGSPQTNTP 946

  Fly  1500 -------------SVQPMN---------HLGQSLPNLNMHHSHTNNTLLVPGSTTSHSGNM---- 1538
                         .|:|:.         |....:..|....|.....:|...|....||.:
 Worm   947 CRDSPTLLITSDDCVEPLQFGRRFEKRYHTADGIDVLKPKISKLPGAILKRFSLNGGSGAVGSSC 1011

  Fly  1539 -LLSPSHR-------------GISYPPPSPTRVPLRRGMAFSTSTKNPPLRKTRNITSQNSINWH 1589
             .|..|.|             |.|           ..|::.::|..|.|..:|  :||:.|
 Worm  1012 KKLESSKRNSQASNAASLDSFGSS-----------TSGISTASSNNNDPSMET--LTSKLS---- 1059

  Fly  1590 QIPATPTPPSPRSQYQSPGVVCMQKSLPLLLPT--NTDEGQGPTQ----PPPPLQKQLSHQAP-L 1647
            .|.......|| |...|.|.:.:....|   ||  ..||.|...:    |||.|.......:| |
 Worm  1060 HISTISINDSP-SSIDSQGTLSISLEAP---PTVLEKDEDQHSIEVSVPPPPELPPPSKTPSPNL 1120

  Fly  1648 PTTIHNQSSTETD 1660
            ||...|:|....:
 Worm  1121 PTHKPNKSKVHCE 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	15/77 (19%)
		RhoGEF	1027..1213	CDD:459876	62/189 (33%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	25/105 (24%)
rhgf-2	NP_001368191.1	RBD_PLEKHG5	186..262	CDD:340588	18/87 (21%)
		RhoGEF	419..608	CDD:238091	63/192 (33%)
		PH_PLEKHG5_G6	665..765	CDD:270064	24/100 (24%)