Protein Alignment CG42674 and plekhg5

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_031761469.1
• Gene: plekhg5 / 100496612
• XenbaseID: XB-GENE-6039487
• Length: 1129
• Species: Xenopus tropicalis
• Alignment Length: 980
• Identity: 255/980 - (26%)
• Similarity: 401/980 - (40%)
• Gaps: 264/980 - (26%)

  Fly   707 FHQHQHHHHHHQ----PTGS-----VSTASCTATSTTSTHAVPSSKHFQSVGEAAATSSSSTLSP 762
            ||...|...|.:    |.||     |||.||...::.::......:....
 Frog    53 FHSTMHFDKHIRFDLPPQGSILARNVSTRSCPPRTSPASDVEEDDEELMD--------------- 102

  Fly   763 HSATSATLGGGGGGGGAGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSSSEFFSVSF 827
                        |.|.....||.                   :.:||.....::..|.|.|::.|
 Frog   103 ------------GKGDKKAAGLK-------------------LSKKKTRRRHTDDPSKECFTLKF 136

  Fly   828 CLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQ 892
              |.:...:.|.:||.|..:|...|..|..|:.:...::.|        |||  .|..|:|::
 Frog   137 --DLNVDIETEIVPAMKKKSLGEVLIPAFERKGIDLNKVDI--------FLD--QSNTPLSLN-- 187

  Fly   893 TDVESLAGHHLCITER-GSNRKPLQKAASFGS-----------------------RQPPPRLLPS 933
            .:.....||:|.:..: |...|..|....|.|                       ..|||
 Frog   188 FEAYRFGGHYLKVKAKPGDEVKVEQAVKDFRSLSLPIMRNTGATSAFIFNPAAERSDPPP----- 247

  Fly   934 VSTEETSESGVAPGKQIKQRWSSIFG-----IKNPQQSQLCEL---------------------- 971
            ...|.|..  :|||:: ::..:...|     :::|.||..|.|
 Frog   248 FRRENTDI--LAPGRR-RKNMNEFLGDASIPVQDPLQSFSCSLPNNGTDTWKNRAASRFSGFFGS 309

  Fly   972 -------------------LNSYAKNGVPQ---RPDSMSFDHPDLVNSLAYLQYMHKSWRDFVN- 1013
                               |:||:..|:|:   ..||...:..|     .||. :..||::.:.
 Frog   310 AATGPFGREIDKMEQLESKLHSYSMFGLPKFGFDQDSWEEEEDD-----TYLT-LEDSWQEIIEV 368

  Fly  1014 SDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVC 1078
            .::::..:...|.|||||:.||..||..|:.:|||||.||..:||.|:|.:|:..:||||::.:.
 Frog   369 PETLTRRQCHQQEAIWELLHTEATYIKKLKVITDLFLCCLLNLQESGILCEVEPDKLFSNIQEII 433

  Fly  1079 EANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNN 1143
            :.:...|:..:.|::..:..|...|....||:||..|.|:|.||..||.|:..|..|.:.|:.:|
 Frog   434 QLHRTLWSTVMVPILEKARKTKSLLNPMDFQKGFKMFESLFKPYIRYCMEEEGCMEYMRNLHRDN 498

  Fly  1144 ALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENF 1208
            .||.||:.|.|..|.||||:|:|::|:|.||||||.|||.:|.|...|::..|:|.:|:.|||.|
 Frog   499 ELFKSYVTWSEKHKQCNRLKLSDMLVKPHQRLTKYPLLLKSILKKTDDLQVRESIILMISSVERF 563

  Fly  1209 VGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHL 1273
            :..||:.:..|||.:||..::.||:||:.||::.:.:||::|:..:: ||.|||.|......|.|
 Frog   564 INHVNSRMRQRQEQQRLAAIISRIDSYEAVDSSTDEVDKILKEFCRL-DLTAPMIGTSPEDTRQL 627

  Fly  1274 FMEGDHKFKDNL-GKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIV-QLAPNNTLN 1336
            .:||..|.|:.. .|.||:|||.|||.|:.|.:.|  ....||||||.|.|:::. :|....:..
 Frog   628 LLEGSLKMKEGKDSKMDVYCFLFTDLFLITKPVKK--AERTKVIRQPLLVDKIVCRELKDPGSFL 690

  Fly  1337 CVYLNEFQVATTAFTLQCTE---AKNWYDALWRAKTIYQRLKR-------------------GGG 1379
            .:|||||:.|..|:|.|.:.   .:.|.:|.:.|:.:.||:::                   ..|
 Frog   691 LIYLNEFRSAVAAYTFQASGQSLCRGWIEAFFNAQNLLQRMRQECLRNQQQVPHLQEEEEDMESG 755

  Fly  1380 GGGSGSGTVGGGDSFRFGGSATSGGT----------ADSLG---VRKSPMNS-----SICSHVSS 1426
            ...:.|.|:....|.....|.:.|.|          .|.|.   ..:.|..|     ||.:..||
 Frog   756 TSAASSPTILRRSSADMLNSQSDGSTETISVVVIDAGDELSSPETEQGPFGSQSDETSISTTASS 820

  Fly  1427 AN------------------NSHSGSVEWNDSRNISVDF-----------------------EKT 1450
            ..                  :|:...:|.|..|:.|:|.                       ::.
 Frog   821 ITPTRDMFESIDSPEAPPVVDSNYLKLEPNGCRSSSIDSAYGTLSPTSLEEFVERQQQEMVEDER 885

  Fly  1451 NSVSSDEGSS----------IMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMN 1505
            .|:||...||          ::.....| ||.|.: .|.||....|         .:|::.:.:.
 Frog   886 ESISSQRSSSPKLRRRTPVQLLPCKSKV-LKSKSE-ASLLHLITTG---------PSTINSEEIT 939

  Fly  1506 HLGQS 1510
            ||.||
 Frog   940 HLTQS 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	19/77 (25%)
		RhoGEF	1027..1213	CDD:459876	80/185 (43%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	38/99 (38%)
plekhg5	XP_031761469.1	RBD_PLEKHG5	129..203	CDD:340588	22/87 (25%)
		RhoGEF	379..568	CDD:238091	81/188 (43%)
		PH_PLEKHG5_G6	625..721	CDD:270064	37/97 (38%)