Protein Alignment CG42674 and plekhg7

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: XP_004912972.1
• Gene: plekhg7 / 100492548
• XenbaseID: XB-GENE-6044182
• Length: 759
• Species: Xenopus tropicalis
• Alignment Length: 865
• Identity: 186/865 - (21%)
• Similarity: 316/865 - (36%)
• Gaps: 215/865 - (24%)

  Fly   596 PGMATSTASTTA-TTAGGTGATTGLFATTGAPGSLGRQANVTEKGERTGVCLSPSAPQPSS-HAS 658
            |.|.....:||| ....|.|....|..::|...:.|.. :||:..:   :|...:.|...: |..
 Frog    10 PVMNEEIFNTTAYEMKVGNGTVCDLIDSSGEVHTSGGN-SVTKDVQ---ICKDNTKPTSETVHRK 70

  Fly   659 PHH-PPTIYTQAP-----------QVVRRMPS-LMLSPTLDETTTTASSSCFGTGHPSAGSFHQH 710
            .|: ||.|....|           |..|:.|: :..||||...                     .
 Frog    71 VHNIPPLILMFPPNETDGNHNTPFQFDRQAPARISTSPTLRRL---------------------R 114

  Fly   711 QHHHHHHQPTGSVSTASCTATSTTSTHAVPSSKHFQSVGEAAATSSSSTL--SPHSATSATLGGG 773
            :|.|.|..|...:...:          ..|:||.     ::|..:.:..|  ||..:...|:
 Frog   115 KHTHGHFMPLQDIFDVT----------KFPTSKE-----QSALNNLAGHLWDSPPWSPQCTI--- 161

  Fly   774 GGGGGAGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSSSEFFSVSFCLDSSQQPDEE 838
                             |||.|.:|.:.......|.|         .|..:.:.|.|       :
 Frog   162 -----------------STSEGVSVSENDRAAIPKDP---------EENINNNNCTD-------D 193

  Fly   839 FIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQTDVESLAGHHL 903
            .:..::..|:..::.|:..|..:..|  |...||..    |:| :|.|       .:::|....|
 Frog   194 ILLHSQWSTVDKSMEHSENRYIIGST--TENYNNDD----DSG-NLSP-------KIKALHHSRL 244

  Fly   904 CITERGSNRKPLQKAASFGSRQPPPRLLPS--VSTEETSESGVAPGKQIKQRW--SSIFGIKNPQ 964
            ....|.|....|.....|     |..||.|  .|......:.|:.....|.:|  |....:...:
 Frog   245 LARRRSSVVLSLPGLEVF-----PGDLLVSDGASDYMYHSTWVSSADSKKPKWPFSKKGTLMKGK 304

  Fly   965 QSQLCELLNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFV------NSDSMSESEVK 1023
            |.|:.:|.|..:           |....|...:..|: ...|:|.:.:      |::::.:|..:
 Frog   305 QKQISDLENCLS-----------SVKIQDFTGNELYI-LKDKTWNEVISMHTAENTENLHKSNRR 357

  Fly  1024 IQTAIWELVTTE-VYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTL 1087
            .|.::|||.|:| .|::..|..:..:|.:.|:.:|....|:|||..|||:|:..:.:.::.|...
 Frog   358 RQESVWELFTSECTYHLDQLLVLKKVFFSALQHLQSNDHLLDVDVVRLFANLEELIQESLNFAVG 422

  Fly  1088 WLYPMVAH---SAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSY 1149
            .|..:.:.   |..:..|.......:.|..  |:...:::||...::...|.:.|...:. |..|
 Frog   423 LLNTIKSRELGSTASFSPPLAGLLTKHFKD--SLCLSHEVYCLNYTSAVIYLESLKQRDD-FAIY 484

  Fly  1150 LAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNN 1214
            |.|||..:.|.||.|:|::|.|:.|||:|.|||..|.|..:||.|..||..:...||:.:..:..
 Frog   485 LKWCEQHEQCRRLHLSDLLVAPLHRLTRYPLLLKNIWKQSTDVTEKIAIYSVKDKVESTLRDLEG 549

  Fly  1215 HLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGD- 1278
            .:....::::.|      :..:|:     |...:.:::.:.|        .|. .::|.|.|.:
 Frog   550 KVKWLDKSQKYK------QLQEVI-----VWPSLWERDKRFF--------IPE-GLKHHFKEPNV 594

  Fly  1279 ------------HKFKDNLGKS----DVHCFLLTDLLLVCK------------------------ 1303
                        |:.|..|.:|    ||:.||..|.||:.|
 Frog   595 ESMLSSLNRDLLHEGKLILTESTRLLDVYLFLFDDFLLITKIKRNKRKSTNLEVNQYPCLHPELQ 659

  Fly  1304 TIAKRGLGALKVIRQPYLTDQL---------IVQLAPNNTLNCVYLNEFQVATTAFTLQC---TE 1356
            .:.|.| |..||:.||...|:|         :......|.....:.|.:|....||.||.   :|
 Frog   660 MVTKEG-GYCKVVDQPIALDRLSLKTVDQYHVTVYGMKNAFMVQHENRYQQCIAAFILQAHTESE 723

  Fly  1357 AKNWYDALWRAKTIYQRLKR 1376
            .|.|...:..|.:.|....|
 Frog   724 KKTWMSQIETAMSCYTETHR 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	14/77 (18%)
		RhoGEF	1027..1213	CDD:459876	57/189 (30%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	34/147 (23%)
plekhg7	XP_004912972.1	DUF4675	89..>186	CDD:464824	27/161 (17%)
		RhoGEF	362..526	CDD:214619	50/166 (30%)
		PH_PLEKHG7	604..732	CDD:270065	31/128 (24%)