Protein Alignment CG42674 and Plekhg6

DIOPT Version :10

• Sequence 1: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Sequence 2: NP_001414672.1
• Gene: Plekhg6 / 100362241
• RGDID: 2318544
• Length: 783
• Species: Rattus norvegicus
• Alignment Length: 823
• Identity: 210/823 - (25%)
• Similarity: 338/823 - (41%)
• Gaps: 202/823 - (24%)

  Fly   892 QTDVESLAGHHLCIT-ERGS-----NRKPLQKAASF--GSRQPPPRLLPSVSTEETSESGVAPGK 948
            ||..:|.||    || .||.     :|:.||....|  ||.|               ..|::|.:
  Rat    28 QTSAQSSAG----ITYPRGGPALDLSRRRLQHYVPFAKGSGQ---------------TRGLSPQE 73

  Fly   949 -QIKQRWSSIFGIKNP------QQSQLCEL---LNSYAKNGVPQRP--DSMSFDHPDLVNSLAYL 1001
             ..::|..:.||:.:|      :.|:..||   |::::..|:|:.|  |...::..:..:|...:
  Rat    74 PDPEKRHGNYFGVGSPYFPKFKEVSKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTI 138

  Fly  1002 QYMHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDV 1065
            :   |||::.| ....|:......|.|:|||:|||:.|:..|:.:|||..|.|..:|..|||.:|
  Rat   139 E---KSWKELVLGHKEMNRELCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEV 200

  Fly  1066 DQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQS 1130
            ....||.||..:...:.:||...|.|::..:..:.:||.....|.|||:|...|.||..||....
  Rat   201 SAETLFGNVPKLIRTHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYIQYCLRVK 265

  Fly  1131 TCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEI 1195
            ....|.:|....|.||.:::.|||..|...|..|.|::::|.||:|||.|||.|:.|...:....
  Rat   266 QTMAYAREQQDTNPLFRTFVQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVLKRSPEPRAQ 330

  Fly  1196 EAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCA 1260
            .|:|.|:.:||:|:..:|..:...:|.|.|..|..||..|:|::.::|.::|.::|.|.: ||..
  Rat   331 LALDNMIVAVESFLQHINGLVRRGEEQESLMAVAQRIGPYEVLEPSSEEVEKHLRQFSTL-DLMT 394

  Fly  1261 PMRGCPAYHVRHLFMEGDHKFKDNL-GKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQ 1324
            |:.|....:.|.|.:||..:.|:.. ||.||:.||.:|:|||.|  .:|.:...||||.|.:.::
  Rat   395 PIEGVAPENTRQLLLEGPVRMKEGREGKMDVYLFLFSDVLLVTK--PQRKVDKAKVIRPPLMLEK 457

  Fly  1325 LIVQ-LAPNNTLNCVYLNEFQVATTAFTLQC---TEAKNWYDALWRAKTIYQRLK---------- 1375
            |:.: |...::...::|.|||..::|.|:.|   ||...|.....:|:...|:||
  Rat   458 LVCRPLRDPHSFLLIHLTEFQCVSSALTVHCSSSTERTQWLQKTQQAQATLQKLKAEEYVQQKRG 522

  Fly  1376 -----RGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPM-NSSICSHVSSANNSHSGS 1434
                 |..|                                |:||. ..|..|...|.:::...:
  Rat   523 LLALYRDQG--------------------------------RESPSPRPSTPSPEDSQSSAEGRA 555

  Fly  1435 VEWNDSRNISV---DFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSA 1496
            :|:.....:.|   ..|.|.||:.|
  Rat   556 LEFTVIPRLVVTEDTDEDTPSVTDD---------------------------------------- 580

  Fly  1497 NTLSVQPMNHLGQSLPNLNMHHSHTNNTLLVPGSTTSHSGNMLLSPSHRGISYPPPSPTRVPLRR 1561
                                               ||.||...|.||       .|..::.||.|
  Rat   581 -----------------------------------TSDSGYGTLIPS-------SPKDSQSPLNR 603

  Fly  1562 GMAFSTSTKNPPLRKTRNITSQNSINWHQIPATPTPPSP-----RSQYQSPGVVCMQKSLPLLLP 1621
                   .::..||:...:|. :::....:|..|.||.|     ||..:.|..:....|||...|
  Rat   604 -------LRSKALRRDPRLTF-STLELRDVPLRPQPPDPQALQRRSAPEMPEGILRGGSLPRRAP 660

  Fly  1622 TNTDEGQGPTQPPPPL----QKQLSHQAPLP-TTIHNQSSTET 1659
            ....|.:..|..|..:    ..:...::||| :..|..|:.|:
  Rat   661 PTWSEEEDETLTPGNVVVETLSRAQRRSPLPHSPAHTDSAGES 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	7/16 (44%)
		RhoGEF	1027..1213	CDD:459876	68/185 (37%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	34/99 (34%)
Plekhg6	NP_001414672.1	None