Protein Alignment gig and TSC2

DIOPT Version :10

• Sequence 1: NP_524177.1
• Gene: gig / 40201
• FlyBaseID: FBgn0005198
• Length: 1847
• Species: Drosophila melanogaster
• Sequence 2: XP_011520938.1
• Gene: TSC2 / 7249
• HGNCID: 12363
• Length: 1825
• Species: Homo sapiens
• Alignment Length: 1993
• Identity: 611/1993 - (30%)
• Similarity: 957/1993 - (48%)
• Gaps: 409/1993 - (20%)

  Fly     3 SKD---KSKFKLFL-----KSLPAGYVGERT---LRPEFERELRPEQPVAQRCRMLK---ELGDT 53
            |||   |.|||:.|     :..|....|::|   :..|..|||..|..:..|.||:.   |:..|
Human     6 SKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKT 70

  Fly    54 QLHNFNLDESAITILFNLTNDLIVPNKPAETRQIALSFYKRLIHTQYKNLTIMREKFFLVIQNHE 118
            :    ..:|.|:..|:....||:.|.:|.|.|...|:..|.::..|.:.|.::|..||.||:::.
Human    71 K----KFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYP 131

  Fly   119 AREDLRHLLELLDTLTDNGKDITNFEEKIGKFMLLWIPAITEANLLTPYLDILVNLIKFNAAHLD 183
            :.|||...||:...|||||:.||..||::..|:|.|:    :..|.:.:|.:||||:|||:.:||
Human   132 SNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWM----DVGLSSEFLLVLVNLVKFNSCYLD 192

  Fly   184 KDILVGIVQNACDLSCSVTVNEIGLQ-CLTILEMVIGYTIFPSEPLPQCITTLCRTVNHAPYCPS 247
             :.:..:||..| |.|..|.:.:.:: .|.:|:.|:.|...|:|.||..|.|||||:|....|..
Human   193 -EYIARMVQMIC-LLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEP 255

  Fly   248 SFKIMKNLLGTQLGYHSMKMMCSILNDRALYDDAHLLRGAVFHLNMNIFGSNIIFQV--SPMTYA 310
            .:|:|:|||||.||:.::..||.::.|||..:||.|||||||.:.|.::|::.::.:  ||
Human   256 CWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSP---- 316

  Fly   311 TNVLTAFLRALDSRQVIVTFEVILSVRMVITK--RQLSEIIWDLICDIMSSIVSNIEYYEEVNIN 373
            |:||.:|.:|:.....:|::|::||:..:|.|  ::|..:.||::.:|:..::..::..:.
Human   317 TSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDS---- 377

  Fly   374 KDRLHHLQINFHENIDCIEKLLQQDRSQILGNVERIYDLIERVADRRPEASVLALIEYRSRRVTA 438
                ..|:...|:.:..:|:|.  |:::..|:.||.::|:||.||:|||:|:|.||.||::.:..
Human   378 ----PELRTIVHDLLTTVEELC--DQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHP 436

  Fly   439 TRPDWLQVLAQFVRRYYRM-SNVNVRIKTIEALVQIMDQNRACYEEEILSRVVLVHLSHIHLESS 502
            .:..|:|.|...:.|::|. |...||||.::.|..::..||..||||:::.||:..||||..:..
Human   437 AKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKD 501

  Fly   503 VQVRVAVARALSNFATHCDTKRCMDLLDILEALINRPFEHTRHGSSSGEGTLAEVTFGLVNNESE 567
            .|||....:.|.:.|..|.|.....||||:|.::.|        |.|....|.|......:  :.
Human   502 HQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMAR--------SLSPPPELEERDVAAYS--AS 556

  Fly   568 ISDIIAAVDGLVKVFAIKLHRLPGIHALKIFNILMDHLELHYERPKIFEHISVVRYKIFAWLLKA 632
            :.|:..||.||:.:...||:.||..||.:::.:|:.|::|||:........|.:|.:.|.:||..
Human   557 LEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLL 621

  Fly   633 RANGSYHIGYPEGSTEVVKFSPYLGID-------------SPLLPQAHPT------------AIS 672
            ||:..:.:|.| ....||:||||...|             .||.|...|.            ::.
Human   622 RADSLHRLGLP-NKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVP 685

  Fly   673 IRRVCKLIVRCLEHDTDYQVFQLVIRELPKVLQNKALVQGN--DIEELANTLLKINLVSNNK--- 732
            ...:.:::::||:.::|::|.:||:..||:.|:.|.|:..:  .:::|.:.|  .:::|..|
Human   686 YSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSAL--CSMLSGPKTLE 748

  Fly   733 --------FKRPTDEFHALVLPAIASLVIYHESLQPQQHYGIITALNSRVLTGIASVCINTMTIL 789
                    |.| || .|..|:|.:.:|:.||..|...:...::..|...::...||.|:..::|.
Human   749 RLRGAPEGFSR-TD-LHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSIC 811

  Fly   790 ILEMPEALMRKLPDVLLQMSKMSDTNALATPVLEFLSLLIHLSKHLFANFTSMHNMYVFAITLPY 854
            .:|||:.:::.||.::::::.:|.|.::|.|:|||||.|..| .||:.||.:.....||||:|||
Human   812 SVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARL-PHLYRNFAAEQYASVFAISLPY 875

  Fly   855 TKPHRYDHYTVSLAHHVIAGWFLKCKLELRRNCVNYIKSSIQSNAKMLSSDIVNLNSLNEDSSNR 919
            |.|.:::.|.|.|||||||.||::|:|..|::.|.:|...::||.      :::.:...|..|.|
Human   876 TNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNV------LLSFDDTPEKDSFR 934

  Fly   920 KRSTSLTER------------GSRNN-----------ANAWN----------------------- 938
            .|||||.||            |..|:           |.|:.
Human   935 ARSTSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSAS 999

  Fly   939 ----DLEMRPQMNNGLRNFHAELAETCFDFLARHTYSPCPSMPKRLPAAEFLLKDGVSQTWLVGN 999
                |.....|.::.|:|.|.||.|||.|.:||:.:|...::|||.|..||||..|.::||||||
Human  1000 LGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN 1064

  Fly  1000 NLVTITTS---------GCPSAPARSGLCERCAQLGKAPSISLNSKSLSDAAPPLSPERERRYTK 1055
            .|||:|||         |..|...:||     .:...:|.:.:               |:.:...
Human  1065 KLVTVTTSVGTGTRSLLGLDSGELQSG-----PESSSSPGVHV---------------RQTKEAP 1109

  Fly  1056 VSLQHSSGNE-SAGSTELTSSSSSNSAAAGGHPHRQISNSSTASLDALSRRGSNPEALGSALGEG 1119
            ..|:..:|.: |.|:.:...|.|      |||..|      ..:||..:     .:.||||...|
Human  1110 AKLESQAGQQVSRGARDRVRSMS------GGHGLR------VGALDVPA-----SQFLGSATSPG 1157

  Fly  1120 AHTGSNTSLLGNSLSQSSVSMSPSSGSV-----VQQPVCVRA-----CTGWAEVLVRRPTGNVSW 1174
            ..|              :.:..|...|.     ||:...:.|     ..||||:||||||||.||
Human  1158 PRT--------------APAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSW 1208

  Fly  1175 ITRIQNPITNDCFGQELPF-NNVVSLFLPTAHGGVFGPD-----------NTIQAPPHTLADPEP 1227
            :..::||::        || :::.::.|......:...:           .::..|..:.|.|.|
Human  1209 LMSLENPLS--------PFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPP 1265

  Fly  1228 EPEAEVNAATAPQASALRSRMVAKARALQR---QEEIH-SVGGNGNGNGNGNGSGNAP------- 1281
            .|               ||..||...:|.:   |.::| ||...|..:........||
Human  1266 LP---------------RSNTVASFSSLYQSSCQGQLHRSVSWAGIASQREAVGCRAPLCLIDSA 1315

  Fly  1282 ---STGGAAAIPIPRVPASGKRGKEAAL-----------CGSVSDGEADDDSLAFEDAQSRARNP 1332
               ..|....:|: .|...|....||||           ..|||..|  :.||..|:...|. .|
Human  1316 VVMEEGSPGEVPV-LVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE--EKSLHAEELVGRG-IP 1376

  Fly  1333 VRRVNSS----PEMSSSWRQSFLTNKPTPLSQEPVKTTADEPQSLLTLKKKTVQYSTKDMRVSCE 1393
            :.||.||    |.:..|::.|           :|:..::..|: |.||
Human  1377 IERVVSSEGGRPSVDLSFQPS-----------QPLSKSSSSPE-LQTL----------------- 1412

  Fly  1394 AIPEEIAGSTPPSQAAALALQPE------SGTLPPKQHSADDVSSHVAGGSNLQAGGSTLKLGKP 1452
               ::|.|. |..:|....|.||      ||||.      .:.::..|.|.:
Human  1413 ---QDILGD-PGDKADVGRLSPEVKARSQSGTLD------GESAAWSASGED------------- 1454

  Fly  1453 PLSPGQPPLLGTGRVTSFGGTSVPQPGALAKSSSSGSNGTNVGVITSDYDNGNNGNGDMMRGRSK 1517
              |.|||                  .|.|..||....:|                    :|.|..
Human  1455 --SRGQP------------------EGPLPSSSPRSPSG--------------------LRPRGY 1479

  Fly  1518 TISVVREVNNGN--TRPPPASSFRNFGAAKPPINTKLCMNPSFIFMQLYTTGQLG-VTDEPLKVG 1579
            |||.......|.  .|....|......|.|.|     .:||||:|:|||.:...| .:::|:.:.
Human  1480 TISDSAPSRRGKRVERDALKSRATASNAEKVP-----GINPSFVFLQLYHSPFFGDESNKPILLP 1539

  Fly  1580 PENSS---AVSLIDLVPPFETHKIGVLYVGQGQCNNEVEILRNSHGSARYVEFLRNIGTLVSLKE 1641
            .|:.|   :|.|:|.:|.::||||.|||||:||.|:|:.||.|.|||.||.|||..:|.|:.||:
Human  1540 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKD 1604

  Fly  1642 AEQNNLFI-MLDRNGADGKFAYIWKDDILQVTFHVATLMPTNLQDDPNCNEKKSHIGNDFVKIIY 1705
            .:.:.::: .||..|.||:|.|.|.|||:|..||:||||||...|...| :||.|:|||||.|:|
Human  1605 CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRC-DKKRHLGNDFVSIVY 1668

  Fly  1706 NESGEEYNLNTISGQFNYACVIVEPLDLNSNRVYVKARSEISKFVCHAEYRIVSDRSAPLLARQM 1770
            |:|||::.|.||.||||:..|||.|||...|.|.::.|.::...|..:..:|||||:.|.:||||
Human  1669 NDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQM 1733

  Fly  1771 ALHANLASLVYQSVQKKHP---YASNWLERLRKLKRLRSKLIE 1810
            |||||:||.|:.|  :.:|   |.|.|:.|||.:||||.::.|
Human  1734 ALHANMASQVHHS--RSNPTDIYPSKWIARLRHIKRLRQRICE 1774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gig	NP_524177.1	DUF3384	40..421	CDD:463376	128/388 (33%)
		Tuberin	566..882	CDD:460965	108/353 (31%)
		PRK12727	<1219..>1418	CDD:237182	52/233 (22%)
		Rap_GAP	1617..1802	CDD:460463	93/188 (49%)
TSC2	XP_011520938.1	DUF3384	54..419	CDD:463376	128/388 (33%)
		Tuberin	555..903	CDD:460965	108/353 (31%)
		Rap_GAP	1580..1766	CDD:460463	93/188 (49%)