DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gig and TSC2

DIOPT Version :9

Sequence 1:NP_524177.1 Gene:gig / 40201 FlyBaseID:FBgn0005198 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_011520940.2 Gene:TSC2 / 7249 HGNCID:12363 Length:1879 Species:Homo sapiens


Alignment Length:1990 Identity:599/1990 - (30%)
Similarity:942/1990 - (47%) Gaps:440/1990 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SKD---KSKFKLFL-----KSLPAGYVGERT---LRPEFERELRPEQPVAQRCRMLKELGDTQLH 56
            |||   |.|||:.|     :..|....|::|   :..|..|||..|..:..|.||:.::.:.   
Human    97 SKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEV--- 158

  Fly    57 NFNLDESAITILFNLTNDLIVPNKPAETRQIALSFYKRLIHTQYKNLTIMREKFFLVIQNHEARE 121
                                     |:|::.          .:.:.|.::|..||.||:::.:.|
Human   159 -------------------------AKTKKF----------EEGERLGVLRALFFKVIKDYPSNE 188

  Fly   122 DLRHLLELLDTLTDNGKDITNFEEKIGKFMLLWIPAITEANLLTPYLDILVNLIKFNAAHLDKDI 186
            ||...||:...|||||:.||..||::..|:|.|:    :..|.:.:|.:||||:|||:.:|| :.
Human   189 DLHERLEVFKALTDNGRHITYLEEELADFVLQWM----DVGLSSEFLLVLVNLVKFNSCYLD-EY 248

  Fly   187 LVGIVQNACDLSCSVTVNEIGLQ-CLTILEMVIGYTIFPSEPLPQCITTLCRTVNHAPYCPSSFK 250
            :..:||..| |.|..|.:.:.:: .|.:|:.|:.|...|:|.||..|.|||||:|....|...:|
Human   249 IARMVQMIC-LLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWK 312

  Fly   251 IMKNLLGTQLGYHSMKMMCSILNDRALYDDAHLLRGAVFHLNMNIFGSNIIFQV--SPMTYATNV 313
            :|:|||||.||:.::..||.::.|||..:||.|||||||.:.|.::|::.::.:  ||    |:|
Human   313 LMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSP----TSV 373

  Fly   314 LTAFLRALDSRQVIVTFEVILSVRMVITK--RQLSEIIWDLICDIMSSIVSNIEYYEEVNINKDR 376
            |.:|.:|:.....:|::|::||:..:|.|  ::|..:.||::.:|:..::..::..:.       
Human   374 LPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDS------- 431

  Fly   377 LHHLQINFHENIDCIEKLLQQDRSQILGNVERIYDLIERVADRRPEASVLALIEYRSRRVTATRP 441
             ..|:...|:.:..:|:|.  |:::..|:.||.::|:||.||:|||:|:|.||.||::.:...:.
Human   432 -PELRTIVHDLLTTVEELC--DQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKD 493

  Fly   442 DWLQVLAQFVRRYYRM-SNVNVRIKTIEALVQIMDQNRACYEEEILSRVVLVHLSHIHLESSVQV 505
            .|:|.|...:.|::|. |...||||.::.|..::..||..||||:::.||:..||||..:...||
Human   494 GWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQV 558

  Fly   506 RVAVARALSNFATHCDTKRCMDLLDILEALINRPFEHTRHGSSSGEGTLAEVTFGLVNNESEISD 570
            |....:.|.:.|..|.|.....||||:|.::.|        |.|....|.|......:  :.:.|
Human   559 RKLATQLLVDLAEGCHTHHFNSLLDIIEKVMAR--------SLSPPPELEERDVAAYS--ASLED 613

  Fly   571 IIAAVDGLVKVFAIKLHRLPGIHALKIFNILMDHLELHYERPKIFEHISVVRYKIFAWLLKARAN 635
            :..||.||:.:...||:.||..||.:::.:|:.|::|||:........|.:|.:.|.:||..||:
Human   614 VKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRAD 678

  Fly   636 GSYHIGYPEGSTEVVKFSPYLGID-------------SPLLPQAHPT------------AISIRR 675
            ..:.:|.| ....||:||||...|             .||.|...|.            ::....
Human   679 SLHRLGLP-NKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSL 742

  Fly   676 VCKLIVRCLEHDTDYQVFQLVIRELPKVLQNKALVQGN--DIEELANTLLKINLVSNNK------ 732
            :.:::::||:.::|::|.:||:..||:.|:.|.|:..:  .:::|.:.|  .:::|..|      
Human   743 LFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSAL--CSMLSGPKTLERLR 805

  Fly   733 -----FKRPTDEFHALVLPAIASLVIYHESLQPQQHYGIITALNSRVLTGIASVCINTMTILILE 792
                 |.| || .|..|:|.:.:|:.||..|...:...::..|...::...||.|:..::|..:|
Human   806 GAPEGFSR-TD-LHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVE 868

  Fly   793 MPEALMRKLPDVLLQMSKMSDTNALATPVLEFLSLLIHLSKHLFANFTSMHNMYVFAITLPYTKP 857
            ||:.:::.||.::::::.:|.|.::|.|:|||||.|..| .||:.||.:.....||||:||||.|
Human   869 MPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARL-PHLYRNFAAEQYASVFAISLPYTNP 932

  Fly   858 HRYDHYTVSLAHHVIAGWFLKCKLELRRNCVNYIKSSIQSNAKMLSSDIVNLNSLNEDSSNRKRS 922
            .:::.|.|.|||||||.||::|:|..|::.|.:|...::||.      :::.:...|..|.|.||
Human   933 SKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNV------LLSFDDTPEKDSFRARS 991

  Fly   923 TSLTER------------GSRNN-----------ANAWN-------------------------- 938
            |||.||            |..|:           |.|:.                          
Human   992 TSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGS 1056

  Fly   939 -DLEMRPQMNNGLRNFHAELAETCFDFLARHTYSPCPSMPKRLPAAEFLLKDGVSQTWLVGNNLV 1002
             |.....|.::.|:|.|.||.|||.|.:||:.:|...::|||.|..||||..|.::||||||.||
Human  1057 ADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLV 1121

  Fly  1003 TITTS---------GCPSAPARSGLCERCAQLGKAPSISLNSKSLSDAAPPLSPERERRYTKVSL 1058
            |:|||         |..|...:||     .:...:|.:.:               |:.:.....|
Human  1122 TVTTSVGTGTRSLLGLDSGELQSG-----PESSSSPGVHV---------------RQTKEAPAKL 1166

  Fly  1059 QHSSGNE-SAGSTELTSSSSSNSAAAGGHPHRQISNSSTASLDALSRRGSNPEALGSALGEGAHT 1122
            :..:|.: |.|:.:...|.|      |||..|      ..:||..:     .:.||||...|..|
Human  1167 ESQAGQQVSRGARDRVRSMS------GGHGLR------VGALDVPA-----SQFLGSATSPGPRT 1214

  Fly  1123 GSNTSLLGNSLSQSSVSMSPSSGSV-----VQQPVCVRA-----CTGWAEVLVRRPTGNVSWITR 1177
                          :.:..|...|.     ||:...:.|     ..||||:||||||||.||:..
Human  1215 --------------APAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMS 1265

  Fly  1178 IQNPITNDCFGQELPF-NNVVSLFLPTAHGGVFGPD-----------NTIQAPPHTLADPEPEPE 1230
            ::||::        || :::.::.|......:...:           .::..|..:.|.|.|.| 
Human  1266 LENPLS--------PFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLP- 1321

  Fly  1231 AEVNAATAPQASALRSRMVAKARALQR---QEEIH-SVGGNGNGNGNGNGSGNAP---------- 1281
                          ||..||...:|.:   |.::| ||...|..:........||          
Human  1322 --------------RSNTVASFSSLYQSSCQGQLHRSVSWAGIASQREAVGCRAPLCLIDSAVVM 1372

  Fly  1282 STGGAAAIPIPRVPASGKRGKEAAL-----------CGSVSDGEADDDSLAFEDAQSRARNPVRR 1335
            ..|....:|: .|...|....||||           ..|||..|  :.||..|:...|. .|:.|
Human  1373 EEGSPGEVPV-LVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE--EKSLHAEELVGRG-IPIER 1433

  Fly  1336 VNSS----PEMSSSWRQSFLTNKPTPLSQEPVKTTADEPQSLLTLKKKTVQYSTKDMRVSCEAIP 1396
            |.||    |.:..|::.|           :|:..::..|: |.||                    
Human  1434 VVSSEGGRPSVDLSFQPS-----------QPLSKSSSSPE-LQTL-------------------- 1466

  Fly  1397 EEIAGSTPPSQAAALALQPE------SGTLPPKQHSADDVSSHVAGGSNLQAGGSTLKLGKPPLS 1455
            ::|.|. |..:|....|.||      ||||.      .:.::..|.|.:               |
Human  1467 QDILGD-PGDKADVGRLSPEVKARSQSGTLD------GESAAWSASGED---------------S 1509

  Fly  1456 PGQPPLLGTGRVTSFGGTSVPQPGALAKSSSSGSNGTNVGVITSDYDNGNNGNGDMMRGRSKTIS 1520
            .|||                  .|.|..||....:|                    :|.|..|||
Human  1510 RGQP------------------EGPLPSSSPRSPSG--------------------LRPRGYTIS 1536

  Fly  1521 VVREVNNGN--TRPPPASSFRNFGAAKPPINTKLCMNPSFIFMQLYTTGQLG-VTDEPLKVGPEN 1582
            .......|.  .|....|......|.|.|     .:||||:|:|||.:...| .:::|:.:..|:
Human  1537 DSAPSRRGKRVERDALKSRATASNAEKVP-----GINPSFVFLQLYHSPFFGDESNKPILLPNES 1596

  Fly  1583 SS---AVSLIDLVPPFETHKIGVLYVGQGQCNNEVEILRNSHGSARYVEFLRNIGTLVSLKEAEQ 1644
            .|   :|.|:|.:|.::||||.|||||:||.|:|:.||.|.|||.||.|||..:|.|:.||:.:.
Human  1597 QSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQP 1661

  Fly  1645 NNLFI-MLDRNGADGKFAYIWKDDILQVTFHVATLMPTNLQDDPNCNEKKSHIGNDFVKIIYNES 1708
            :.::: .||..|.||:|.|.|.|||:|..||:||||||...|...| :||.|:|||||.|:||:|
Human  1662 DKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRC-DKKRHLGNDFVSIVYNDS 1725

  Fly  1709 GEEYNLNTISGQFNYACVIVEPLDLNSNRVYVKARSEISKFVCHAEYRIVSDRSAPLLARQMALH 1773
            ||::.|.||.||||:..|||.|||...|.|.::.|.::...|..:..:|||||:.|.:|||||||
Human  1726 GEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALH 1790

  Fly  1774 ANLASLVYQSVQKKHP---YASNWLERLRKLKRLRSKLIE 1810
            ||:||.|:.|  :.:|   |.|.|:.|||.:||||.::.|
Human  1791 ANMASQVHHS--RSNPTDIYPSKWIARLRHIKRLRQRICE 1828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gigNP_524177.1 DUF3384 40..467 CDD:288697 135/432 (31%)
HEAT repeat 484..515 CDD:293787 11/30 (37%)
Tuberin 566..882 CDD:281532 108/353 (31%)
Rap_GAP 1617..1802 CDD:280332 93/188 (49%)
TSC2XP_011520940.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144555
Domainoid 1 1.000 251 1.000 Domainoid score I2111
eggNOG 1 0.900 - - E1_KOG3687
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H462
Inparanoid 1 1.050 747 1.000 Inparanoid score I585
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47539
OrthoDB 1 1.010 - - D341431at2759
OrthoFinder 1 1.000 - - FOG0005485
OrthoInspector 1 1.000 - - oto88903
orthoMCL 1 0.900 - - OOG6_104155
Panther 1 1.100 - - LDO PTHR10063
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1559
SonicParanoid 1 1.000 - - X5077
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

Return to query results.
Submit another query.