DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gig and rap1gap2a

DIOPT Version :9

Sequence 1:	NP_524177.1	Gene:	gig / 40201	FlyBaseID:	FBgn0005198	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_021337099.1	Gene:	rap1gap2a / 561339	ZFINID:	ZDB-GENE-061013-179	Length:	843	Species:	Danio rerio

Alignment Length:	702	Identity:	143/702 - (20%)
Similarity:	256/702 - (36%)	Gaps:	205/702 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1203 TAHGGVFGPDNTIQAPPHTLADPEPEPEAEVNAATAPQASAL--------RSRMVAKARALQRQE 1259
            ||..|. ||.:.::..|.:::|.||    :||:..|...:|:        ..|...:.|..:|::
Zfish    18 TAQDGP-GPKSVLECGPDSMSDSEP----KVNSKKAGIRAAVILIGLLHKSRRQKEREREKERKQ 77

  Fly  1260 EIHSVGGNGNGNGNGNGSGNAPSTGGAAAIPIPRVPASGKRGKEAALCGSVSDGEADDDSLAFED 1324
            |:.::                      :::|:...|.|..|.....:           .|..|.|
Zfish    78 ELLTI----------------------SSVPLGECPPSPPRTAPPTM-----------KSAEFFD 109

  Fly  1325 AQSRARNPVRRVNSSPEMSSSWRQSFLTNKPTPLSQEPVKTTADEPQSLLTLKKKTVQYSTKDMR 1389
            ...|.:.|      ..|.:..::..::   |.|..::.::.....||.:|   .:...|..:|
Zfish   110 MLERMQIP------KTEETKKYKDDYI---PYPRIEDVLEKGGPYPQVIL---PQFGGYWIED-- 160

  Fly  1390 VSCEAIPEEIAGSTPPSQAAALALQPESGTLPPKQHSADDVSSHVAGGSNLQAGGSTLKLGKPPL 1454
                  ||...| ||.|..::..           :...||:|....||    .||...::.....
Zfish   161 ------PEAPVG-TPTSSDSSFC-----------EEENDDLSPSGGGG----GGGFGYRMECNST 203

  Fly  1455 SPG-QPPLLGTGRVTSFGGTSVPQPGALAKSSSSGSNGTNVGVITSDYD--NGNNGNGDMMRGRS 1516
            |.. :...||...:..:           ..:||.|..     :::..|:  :|......|:|.::
Zfish   204 SRAYRKHFLGKEHMNYY-----------CTASSMGHL-----IMSLKYEDADGQESLRIMLRSKT 252

  Fly  1517 KTISVVREVNNGNTRPP-------PASSFRNFGAAKPPINTKLCMNPSFIFMQLYTTGQLGVTDE 1574
            ||:         :.|.|       |:.         |.|...||.:         .||
Zfish   253 KTL---------HERIPLEGLIHLPSI---------PQIAKLLCDD---------VTG------- 283

  Fly  1575 PLKVGPENSSAVSLIDLVPPFETH------KIGVLYVGQGQCNNEVEILRNSHGSARYVEFLRNI 1633
             ||..|......|  .|:..|:.|      |.||:|...||.:.| |:..|:..:..:.|||..:
Zfish   284 -LKFNPVLYPRAS--QLIVSFDEHEVNNTFKFGVIYQKFGQTSEE-ELFGNNEETPAFAEFLSVL 344

  Fly  1634 GTLVSLKEAE--QNNLFIMLDRNGADGKFAYIWKDDILQVTFHVATLMPTNLQDDPNCNEKKSHI 1696
            |..:.|::.:  :..|.:...:.|::..:....:.:|:   |||:|.:|.. :.|....::|.||
Zfish   345 GDNIELQDFKGFRGGLDVSHGQTGSESVYTTFRQREIM---FHVSTKLPFT-EGDIQQLQRKRHI 405

  Fly  1697 GNDFVKIIYNESGEEYNLNTISGQFNYACVIVEP----LDLNSNRVYVKARSEISKF-------- 1749
            |||.|..|:.|....:..:.|:..|.:|.::|:.    .|..:.:|.|.||.::..|
Zfish   406 GNDIVAAIFQEEPTPFVPDMIASNFLHAYILVQAENPCTDHTTYKVSVTAREDVPPFGPPLPNPS 470

  Fly  1750 ---------------VCHAE---YRIVSDRSAPLLAR-QMALHANLASLVYQSVQKKHPYAS--- 1792
                           :.:||   |:  ||:.|.|..| :.||..||...:::..|......|
Zfish   471 VFKKGPEFREYFLTKLINAENACYK--SDKFAKLEERTRAALLDNLHDELHRQTQATVGLGSATD 533

  Fly  1793 ----------NWLERLRKLKRLRSKLIEGL-NSQQKSGSASSGIGINASAIG 1833
                      ..||..::..|:||..:|.: ..:.||..|.:|:..:.|..|
Zfish   534 EEKLENGGHGGLLESFKRAMRVRSHSMETMVTHKHKSPGAVAGVPSSLSGGG 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gig	NP_524177.1	DUF3384	40..467	CDD:288697
		HEAT repeat	484..515	CDD:293787
		Tuberin	566..882	CDD:281532
		Rap_GAP	1617..1802	CDD:280332	50/230 (22%)
rap1gap2a	XP_021337099.1	Rap_GAP	328..507	CDD:307998	42/184 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940