DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gig and RapGAP1

DIOPT Version :9

Sequence 1:	NP_524177.1	Gene:	gig / 40201	FlyBaseID:	FBgn0005198	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster

Alignment Length:	782	Identity:	169/782 - (21%)
Similarity:	275/782 - (35%)	Gaps:	271/782 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1221 TLAD---PEPEPEAEVNAATAPQASALR--SRMV-------AKARALQRQEEI-----HSVGGNG 1268
            ||.|   |.....:|::.|.:..||:.:  .||:       .|...|::.|..     ||    .
  Fly     6 TLVDHGHPIIVGSSEISLAPSSAASSPKPLHRMIKYWRNSSGKIPGLRKSESFAEYRRHS----S 66

  Fly  1269 NGNGNGNGSGNAPSTGGAAAIPIPRVPASGKRGKEAALCGSVSDGEADDDSLAFEDAQSRARNPV 1333
            |......|||...||..|..:...|:        |...|.::       |.|.         .|:
  Fly    67 NSATISGGSGGRSSTSSARQLQYQRL--------EMESCENI-------DMLT---------EPL 107

  Fly  1334 RRVNSSPEMSSSWRQSFLTNKPTPLSQEPV------KTTADEPQSLLTLKKKTVQYSTKDM---- 1388
            ||           :.:|:.|..   .|:|.      .:....|:.|     :....:|:|:
  Fly   108 RR-----------QHAFMANTQ---KQQPAGGGSGSGSVTHSPERL-----RGATTATQDLFELL 153

  Fly  1389 -RVSCEAIPEEIA------------GSTPPSQAAALALQPESGTLPPKQHSADDVSSHVAGGSNL 1440
             ||.|..:.::..            ||....:..            |:.||..|..:|...| .|
  Fly   154 ERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERV------------PQPHSPHDSHAHPHNG-GL 205

  Fly  1441 QAGG--------------STLKLGKPPLSPGQPPLLGTGRVTSFGGTSVPQPGALAKSSSS-GSN 1490
            |..|              ||:.......:|..|.|.|   |.|..|..:...|...:|.|| .||
  Fly   206 QHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSG---VVSASGCQLLSNGHHYQSQSSVSSN 267

  Fly  1491 GTNVGVIT-------------------------------SDYDNGNNGNGDMMRGRSKTISVVRE 1524
            .:.|..|.                               ::::.|.:..|:.:..::..::   :
  Fly   268 SSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMA---K 329

  Fly  1525 VNNGNTRPPPASSFRNFGAAKP----------------PINTKLCMNPSF--IFMQLYTTGQLGV 1571
            ....:|    |..:|.|.||:.                .|.|:...|...  |.|:|.|    |.
  Fly   330 FETDDT----AKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRT----GT 386

  Fly  1572 TDEPLKVG-----------------------------PENSSAVSLID---LVPPFETHKIGVLY 1604
            ..|.|.|.                             |:.|..:|:.|   ||..|   |.||||
  Fly   387 MHELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHF---KFGVLY 448

  Fly  1605 VGQGQCNNEVEILRNSHGSARYVEFLRNIGTLVSLKEAE--QNNLFIMLDRNGADGKFAY--IWK 1665
            ...||...| |:..|...|..:.|||..:|..:.||:.:  :..|.|   :||..|..|.  ::|
  Fly   449 QRYGQTTEE-ELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDI---QNGHTGDTAVYEVFK 509

  Fly  1666 DDILQVTFHVATLMPTNLQDDPNCNEKKSHIGNDFVKIIYNESGEEYNLNTISGQFNYACVIVEP 1730
            :  .::.|||:||:| :.:.||...::|.|||||.|.|::.|:...::.:.|:..|.:|.::|:|
  Fly   510 E--REIMFHVSTLLP-HTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQP 571

  Fly  1731 LDLNS----NRVYVKARSEISKF----VCHAEYRIVSDRSAPLLARQMALHANLASLVYQSVQKK 1787
            ::.|:    .:|.|.||.::..|    ...|.:|...:....:|.:.:    |..:..|::
  Fly   572 IEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLI----NAENACYKA---- 628

  Fly  1788 HPYASNWLERLRKL-KRLRSKLIEGL---------------NSQQKSGS-------ASSGIGINA 1829
                    |:..|| :|.|:.|::.|               .||..:||       |.||.|.||
  Fly   629 --------EKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNA 685

  Fly  1830 SA 1831
            .:
  Fly   686 GS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gig	NP_524177.1	DUF3384	40..467	CDD:288697
		HEAT repeat	484..515	CDD:293787
		Tuberin	566..882	CDD:281532
		Rap_GAP	1617..1802	CDD:280332	51/197 (26%)
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	4/20 (20%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	52/200 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940