DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gig and tsc2

DIOPT Version :9

Sequence 1:NP_524177.1 Gene:gig / 40201 FlyBaseID:FBgn0005198 Length:1847 Species:Drosophila melanogaster
Sequence 2:NP_592909.1 Gene:tsc2 / 2543339 PomBaseID:SPAC630.13c Length:1339 Species:Schizosaccharomyces pombe


Alignment Length:2015 Identity:362/2015 - (17%)
Similarity:616/2015 - (30%) Gaps:846/2015 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNSKDKSKFKLFLKSLPAGYVGERTLRPEFERELRPEQPVAQRCRMLKELGDTQLHNFNLDESAI 65
            ||:|.    .|.|.|.||  :.:..:...|:..|    |..:|.::::.:.....:......|.|
pombe     1 MNNKS----LLDLSSEPA--IKDTDILSYFDANL----PFKKRHQIVRSIYHGLKYYIYSSTSII 55

  Fly    66 TILFNLTNDLIVPNKPAETRQIALSFYKRLIHTQYKNLTIM-REKFFLVIQNHEARE--DLRHLL 127
            .:..|:.:.:...|..|..|::..:...|.:.|| |:|:|: |..||..|:....::  :|:..|
pombe    56 QVWQNIQDFISTKNDNAAFRELVYNLMMRYVSTQ-KHLSIIERHTFFQTIEKDPFQDIAELQLRL 119

  Fly   128 ELLDTLTDNGKDITNFEEKIGKFM-------LLWIPAITE----------ANLL--TPYLDILVN 173
            :.|..|||.|..|:..|.::|..:       |.|....||          .:||  ........|
pombe   120 KSLSVLTDEGHKISGIENRVGPLLSAWFNQYLQWQSQATELQGKDADSKLVHLLFFKSLFKFSTN 184

  Fly   174 LIKFNAAHLDKDILVGIVQNACDLSCSVTVNEIGLQCLTILEMVIGYTIFPSEPLPQCITTLCRT 238
            |:||....:.:..::.:|.:...:.....:.::..:.|...:.:|.|::.|...|...:..||.|
pombe   185 LVKFQWFLVPEPQMLQLVNSVVQICNHARLEDVVTEVLMFFDSMIRYSVIPKASLYDTVLILCST 249

  Fly   239 -VNHAPYCPSSFKIMKNLLGTQLGYHSMKMMCSILNDRALYD--DAHLLRGAV----FHLNMNI- 295
             ::...|...:..::.||:.:.:...:.:.:.:||.    |:  :.:.:||||    |.:...: 
pombe   250 YISTYSYSKLAQSVIFNLISSPVSNLAFENVFNILQ----YNRSNVNAVRGAVRLMRFLMLQEVK 310

  Fly   296 --------FGSNIIFQVSPMTYATNVLTAFLRALDSRQVIVTFEVI----LSVRMVITKRQLSEI 348
                    ..|:|.|...|:.:..|               |.||::    |.:|......:|:.:
pombe   311 NDAIASITLSSSIEFTEFPLGFNEN---------------VDFEILGTVYLFLRTPSILNRLNFL 360

  Fly   349 IWDLICDIMSSIVSNIEYYEEVNINKDRLHHLQINFHENIDCIEKLLQQDRSQILGNVERIYDLI 413
            .|..|.:|:.       |..:         :|.:....:.:...|      :....|   |||  
pombe   361 DWHRILNILM-------YCSQ---------YLPLKASTSKEAFSK------TAAFAN---IYD-- 398

  Fly   414 ERVADRRPEASVLALIEYRSRRVTATRPDWLQVLAQFVR----RYYRMSNV-----NVRIKTIEA 469
             ||.|.....:::.|::....::.....|.|.||...:|    |.:...|:     ...:..:|.
pombe   399 -RVLDFLDFEALIPLLQQFQVKLVFFLKDVLPVLKPKIRKKLLRLFETYNLIFPCNQYWVFNLEF 462

  Fly   470 LVQIMDQNRACYEEEILSRVVLVHL----SHIHLESSVQVRVA-----VARALSNFATHCDTKRC 525
            |:.|..    |...::..|.:|..|    ..:..|:|..:..:     |..:.|..:..|.....
pombe   463 LLGIYQ----CKTFDLEDRALLFKLVEDACSVADENSAPILCSKFLFPVIESFSKESDDCVVSPV 523

  Fly   526 MDLLDILEALINRP-----FEHTRHGSSSGEGTLAEVTFGLVNNESEISDIIAAVDGLVKVFAIK 585
            .::|..|......|     .:|              :...|:::.|.::....|...|:::|   
pombe   524 YNMLFFLSVNFQNPGLKDCIDH--------------IFQQLISDTSSVTVRRLATSTLIRLF--- 571

  Fly   586 LHRLPGIHALKIFNILMDHLELHYERPKIFEHISVVRYKIFAWLLKARANG-SYHIGYPEGSTEV 649
            .:......|:.|...|...||: .|.|. |..:|  |.....:.|:.|||| |.:|.......|.
pombe   572 YYYYDLRDAVPIQETLAKMLEI-LETPS-FPFVS--RMLCLQFFLRFRANGTSIYICENIDLNEP 632

  Fly   650 VKFSPYLGIDSPLLPQAHPTAISI-----------RRVCKLIVRCLEHDTDY------------- 690
            .|   .|.:||.|:|..:|.:.|.           .|....:::...|.|:|             
pombe   633 FK---VLNVDSELIPAVYPISDSFVNSATVEKHIWERKENDLIKISNHSTEYGKDFVTFPTSSLL 694

  Fly   691 -------------QVFQLVIRELPKVLQNKALVQGNDIEELANTLLKINLVSNNKFKR------- 735
                         .:...:|..|...:.|:::..| .:||:.|.|   :.:.:..|:|       
pombe   695 RFYRKSMATESNWTILMFMITHLADQISNRSMFIG-ALEEIYNLL---DFMCDIVFERVSISAEI 755

  Fly   736 PTDEFHA-LVLPAIAS---LVIYHESLQPQQHYGIITALNSRVLTGI------ASVCINTMTILI 790
            |::...| :::|.:.:   |.:||:.....|...:::..    ..|:      ..|.|:::.:..
pombe   756 PSNIRKANIMIPILQNVQMLFVYHDQFSRAQEDELVSVF----FAGLQKWNEACHVSIHSLMLCC 816

  Fly   791 LEMPEALMRKLPDVLLQMSKMSDTNALATPVLEFLSLLIHLSKHLFANFTSMHNMYVFAITLPYT 855
            .|:|.::.::||.:|:.:|::.....|:..:||||..|..| ..|.||||......:|||.|.|.
pombe   817 YELPVSIRKQLPAILVTLSRLITKPDLSVHILEFLCSLARL-PDLIANFTDADYRQIFAIALKYI 880

  Fly   856 KPHR-------------------YDHYTVSLAHHVIAGWFLKCKLELRRNCVNYIKSSIQSNAKM 901
            : ||                   |..|.::||:.|:..|||..:|..|:..|.:|          
pombe   881 Q-HRDFTKESKDSNDTESILKNSYSSYVLALAYSVLQIWFLSLRLTERKKFVPWI---------- 934

  Fly   902 LSSDIVNLNSLNEDSSNRKRSTSLTERGSRNNANAWNDLEMRPQMNNGLRNFHAELAETC---FD 963
                              .|...|...|             :|            |.:.|   :|
pombe   935 ------------------LRGLKLASEG-------------KP------------LEDLCLVQYD 956

  Fly   964 FLARHTYSPCPSMPKRLPAAEFLLKDGVSQTWLVGNNLVTITTSGCPSAPARSGLCERCAQLGKA 1028
            .:.:..||   :.......:.|:..|..|:||:.||:|.||                        
pombe   957 MMQQFCYS---NSDINNQTSTFVDSDVESETWIRGNSLFTI------------------------ 994

  Fly  1029 PSISLNSKSLSDAAPPLSPERERRYTKVSLQHSSGNESAGSTELTSSSSSNSAAAGGHPHRQISN 1093
             ::|:||                                                          
pombe   995 -NVSVNS---------------------------------------------------------- 1000

  Fly  1094 SSTASLDALSRRGSNPEALGSALGEGAHTGSNTSLLGNSLSQSSVSMSPSSGSVVQQPVCVRACT 1158
                                                                             
pombe  1001 ----------------------------------------------------------------- 1000

  Fly  1159 GWAEVLVRRPTGNVSWITRIQNPITNDCFGQELPFNNVVSL--FLPTAHGGVFGPDNTIQAPPHT 1221
            |:.|.::|||||...:                 .|.|..||  ||                    
pombe  1001 GFLEAVIRRPTGTTQY-----------------TFRNEASLQKFL-------------------- 1028

  Fly  1222 LADPEPEPEAEVNAATAPQASALRSRMVAKARALQRQEEIHSVGGNGNGNGNGNGSGNAPSTGGA 1286
                                                                             
pombe  1029 ----------------------------------------------------------------- 1028

  Fly  1287 AAIPIPRVPASGKRGKEAALCGSVSDGEADDDSLAFEDAQSRARNPVRRVNSSPEMSSSWRQSFL 1351
                                                                       |.::..
pombe  1029 -----------------------------------------------------------WEENLT 1034

  Fly  1352 TNKPTPLSQEPVKTTADEPQSLLTLKKKTVQYSTKDMRVSCEAIPEEIAGSTPPSQAAALALQPE 1416
            ::|.                                                             
pombe  1035 SSKA------------------------------------------------------------- 1038

  Fly  1417 SGTLPPKQHSADDVSSHVAGGSNLQAGGSTLKLGKPPLSPGQPPLLGTGRVTSFGGTSVPQPGAL 1481
                                                                             
pombe  1039 ----------------------------------------------------------------- 1038

  Fly  1482 AKSSSSGSNGTNVGVITSDYDNGNNGNGDMMRGRSKTISVVREVNNGNTRPPPASSFRNFGAAKP 1546
                                         :.||                                
pombe  1039 -----------------------------LTRG-------------------------------- 1042

  Fly  1547 PINTKLCMNPSFIFMQLYTTGQLGVTDEPLKVGPENSS----AVSLIDLVPPFETHKIGVLYVGQ 1607
                .||...||:...|...| :.:.::||.: |.|..    |:|:.|.:|..|:.|.|::|||.
pombe  1043 ----LLCTPSSFVSHFLDPHG-ISLYNQPLLL-PSNDDSVRRAISVFDRIPVIESLKAGLVYVGY 1101

  Fly  1608 GQCNNEVEILRNSHGSARYVEFLRNIGTLVSLKEAEQNNLFIMLDR-NGADGKFAYIWKDDILQV 1671
            .| ..|.:||.|::.|..::.||..:|||..|| .:|......||| |..||.|||.|||.:.|:
pombe  1102 QQ-RREADILANTNPSEDFLTFLNGLGTLFELK-TDQKVFAGGLDRENDIDGAFAYCWKDKVTQM 1164

  Fly  1672 TFHVATLMPTNLQDDPNCNEKKSHIGNDFVKIIYNESGEEYNLNTISGQFNYACVIVEPLDLNSN 1736
            .||..|:||||::.||.|..||.|||||||.||:||||.||:.:||..|||:..:::.|...:..
pombe  1165 VFHCTTMMPTNIEHDPGCTLKKRHIGNDFVTIIFNESGLEYDFDTIPSQFNFVNIVITPESESIR 1229

  Fly  1737 RV-------YVKARSEIS-KFVCHAEYRIVSDRSAPLLARQMALHANLASLVYQSVQKKHPYASN 1793
            |.       .|||.::.. .|.....|:|||..:.|.:.|.:.|:|.:.|.:|.  :....|...
pombe  1230 RTGRQIKFYKVKALTKYDIDFSLFRRYKIVSSDALPAIVRDVTLNAAVFSHIYH--RSAGDYVHI 1292

  Fly  1794 WLERLRKLKRLRSKLIEGLNSQQKSGSASSGIGINASAIGSD--MDDQR----------GDFIKY 1846
            |.||||:|||||.|                   ..||.:..|  :|:|.          .||..|
pombe  1293 WAERLRQLKRLREK-------------------FQASVLPEDYNLDEQTKTKLQNGTNFSDFTSY 1338

  Fly  1847  1846
            pombe  1339  1338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gigNP_524177.1 DUF3384 40..467 CDD:288697 89/477 (19%)
HEAT repeat 484..515 CDD:293787 6/39 (15%)
Tuberin 566..882 CDD:281532 87/389 (22%)
Rap_GAP 1617..1802 CDD:280332 78/193 (40%)
tsc2NP_592909.1 DUF3384 30..479 CDD:288697 94/500 (19%)
Tuberin <699..924 CDD:281532 53/234 (23%)
Rap_GAP 1110..1301 CDD:280332 78/193 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 137 1.000 Domainoid score I1250
eggNOG 1 0.900 - - E1_KOG3687
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 283 1.000 Inparanoid score I660
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005485
OrthoInspector 1 1.000 - - oto100728
orthoMCL 1 0.900 - - OOG6_104155
Panther 1 1.100 - - LDO PTHR10063
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1559
SonicParanoid 1 1.000 - - X5077
TreeFam 00.000 Not matched by this tool.
109.980

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