DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gig and Tsc2

DIOPT Version :9

Sequence 1:NP_524177.1 Gene:gig / 40201 FlyBaseID:FBgn0005198 Length:1847 Species:Drosophila melanogaster
Sequence 2:NP_036812.2 Gene:Tsc2 / 24855 RGDID:3908 Length:1809 Species:Rattus norvegicus


Alignment Length:2004 Identity:606/2004 - (30%)
Similarity:955/2004 - (47%) Gaps:431/2004 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SKD---KSKFKLFL-----KSLPAGYVGERT---LRPEFERELRPEQPVAQRCRMLKELGDTQLH 56
            |||   |.|||:.|     :..|....|::|   :..|..|||..|..:..|.||:.::.|. ..
  Rat     6 SKDSGLKEKFKILLGLGTSRPNPRCAEGKQTEFIITAEILRELSGECGLNNRIRMIGQICDV-AK 69

  Fly    57 NFNLDESAITILFNLTNDLIVPNKPAETRQIALSFYKRLIHTQYKNLTIMREKFFLVIQNHEARE 121
            ...|:|.|:..|:...:||:.|.:|.|.|...|:..|.::..|...|.::|..||.||:::.:.|
  Rat    70 TKKLEEHAVEALWKAVSDLLQPERPPEARHAVLALLKAIVQGQGDRLGVLRALFFKVIKDYPSNE 134

  Fly   122 DLRHLLELLDTLTDNGKDITNFEEKIGKFMLLWIPAITEANLLTPYLDILVNLIKFNAAHLDKDI 186
            ||...||:...|||||:.||..||::.:|:|.|:    :..|.:.:|.:||||:|||:.:|| :.
  Rat   135 DLHERLEVFKALTDNGRHITYLEEELAEFVLQWM----DVGLSSEFLLVLVNLVKFNSCYLD-EY 194

  Fly   187 LVGIVQNACDLSCSVTVNEIGLQ-CLTILEMVIGYTIFPSEPLPQCITTLCRTVNHAPYCPSSFK 250
            :..:|...| |.|..||:.:.:: .|.:|:.|:.|...|:|.||..|.|||||||....|...:|
  Rat   195 IAPMVHMIC-LLCIRTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFIITLCRTVNVKELCEPCWK 258

  Fly   251 IMKNLLGTQLGYHSMKMMCSILNDRALYDDAHLLRGAVFHLNMNIFGSNIIFQV--SPMTYATNV 313
            :|:|||||.||:.::..||.|:.:|:..:||.|||||||.:.|.::|::.::.:  ||    |:|
  Rat   259 LMRNLLGTHLGHSAIYNMCRIMENRSYMEDAPLLRGAVFFVGMALWGAHRLYSLKNSP----TSV 319

  Fly   314 LTAFLRALDSRQVIVTFEVILSVRMVITK--RQLSEIIWDLICDIMSSIVSNIEYYEEVNINKDR 376
            |.:|..|:.....:|::|::||:..:|.|  ::|..:.||::.||:..::..::     |::...
  Rat   320 LPSFYEAMTCPNEVVSYEIVLSITRLIKKYRKELQAVTWDILLDIIERLLQQLQ-----NLDSPE 379

  Fly   377 LHHLQINFHENIDCIEKLLQQDRSQILGNVERIYDLIERVADRRPEASVLALIEYRSRRVTATRP 441
            |..:   .|:.:..:|:|.  |:::..|:.||.|:|:|..||:|||:|:|.||.||::.:...:.
  Rat   380 LRTI---VHDLLTTVEELC--DQNEFHGSQERYYELVESYADQRPESSLLNLITYRAQSIHPAKD 439

  Fly   442 DWLQVLAQFVRRYYRMS-NVNVRIKTIEALVQIMDQNRACYEEEILSRVVLVHLSHIHLESSVQV 505
            .|:|.|...:.|::|.. ...||||.::.|..::..||..||||:::.||:..||||..:...||
  Rat   440 GWIQNLQLLMERFFRNECRSAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQV 504

  Fly   506 RVAVARALSNFATHCDTKRCMDLLDILEALINR----PFEHTRHGSSSGEGTLAEVTFGLVNNES 566
            |....:.|.:.|..|.|.....||||:|.::.|    |.|            |.|....:.:  :
  Rat   505 RKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPLE------------LEERDLAVYS--A 555

  Fly   567 EISDIIAAVDGLVKVFAIKLHRLPGIHALKIFNILMDHLELHYERPKIFEHISVVRYKIFAWLLK 631
            .:.|:..||.||:.:...||:.||..||.:::..|:.|::|||:........|.:|.:.|.:||.
  Rat   556 SLEDVKTAVLGLLVILQTKLYTLPASHATRVYETLISHIQLHYKHGYSLPIASSIRLQAFDFLLL 620

  Fly   632 ARANGSYHIGYPEGSTEVVKFSPYLGID-------------SPLLPQAH-----PTAISIR---- 674
            .||:..:.:|.| ....||:||||...|             .||.|...     ||..::|    
  Rat   621 LRADSLHRLGLP-NKDGVVRFSPYCLCDCAELDRASEKKASGPLSPPTGPPSPVPTGPAVRLGHL 684

  Fly   675 ---RVCKLIVRCLEHDTDYQVFQLVIRELPKVLQNKALVQGN--DIEELANTLLKINLVSNNK-- 732
               .:.:::::||:.:||::|.:||:.:||:.|:.|.|:..:  .:::|::.|  .:::|..|  
  Rat   685 PYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYKVLIFTSPCSVDQLSSAL--CSMLSAPKTL 747

  Fly   733 ---------FKRPTDEFHALVLPAIASLVIYHESLQPQQHYGIITALNSRVLTGIASVCINTMTI 788
                     |.| || .|..|:|.:.:|:.||..|...:...::..|...::...||.|:..:.|
  Rat   748 ERLRGTPEGFSR-TD-LHLAVVPVLTALISYHNYLDKTRQREMVYCLEQGLIYRCASQCVVALAI 810

  Fly   789 LILEMPEALMRKLPDVLLQMSKMSDTNALATPVLEFLSLLIHLSKHLFANFTSMHNMYVFAITLP 853
            ..:|||:.:::.||.::::::.:|.|.::|.|:|||||.|..| .||:.||.:.....||||:||
  Rat   811 CSVEMPDIIIKALPVLVVKLTHISATASMAIPLLEFLSTLARL-PHLYRNFAAEQYASVFAISLP 874

  Fly   854 YTKPHRYDHYTVSLAHHVIAGWFLKCKLELRRNCVNYIKSSIQSNAKMLSSDIVNLNSLNEDSSN 918
            ||.|.:::.|.|.|||||||.||::|:|..|::.|.||...::||.      :::.:...|....
  Rat   875 YTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITKGLRSNV------LLSFDDTPEKDKF 933

  Fly   919 RKRSTSLTER------------GSRNN-----------ANAWN---------------------- 938
            |.|||||.||            |..|:           |.|:.                      
  Rat   934 RARSTSLNERPKSLRIARAPKQGLNNSPPVKEFKESCAAEAFRCRSISVSEHVVRSRIQTSLTSA 998

  Fly   939 -----DLEMRPQMNNGLRNFHAELAETCFDFLARHTYSPCPSMPKRLPAAEFLLKDGVSQTWLVG 998
                 |.....|.::.|:|.|.||.|||.|.:||:.:|...::|||.|..||||..|.::|||||
  Rat   999 SLGSADENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG 1063

  Fly   999 NNLVTITTSGCPSAPARSGLCERCAQLGKAPSISLNSKSLSDAAPPLSPERERRYTKVSLQHSSG 1063
            |.|||:|||......:..||.....|.|.|.|        ||   |.:..|:.:.....|:..:|
  Rat  1064 NKLVTVTTSVGTGTRSLLGLDSGDLQGGSASS--------SD---PGTHVRQTKEAPAKLESQAG 1117

  Fly  1064 NE-SAGSTELTSSSSSNSAAAGGHPHRQISNSSTASLDALSRRGSNPEALGSALGEGAHTGSNTS 1127
            .: |.|:.:...|.|      |||..|      ...||.     |.|           :|....:
  Rat  1118 QQVSRGARDRVRSMS------GGHGLR------VGVLDT-----SAP-----------YTPGGPA 1154

  Fly  1128 LLGNSLSQSSVSMSPSSGSVVQQPVCVRA---------CTGWAEVLVRRPTGNVSWITRIQNPIT 1183
            .||...:.::....|.:|:  |.|...:|         ..||||:||||||||.||:..::||::
  Rat  1155 SLGAQAAPAARPEKPCAGA--QLPAAEKANLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLS 1217

  Fly  1184 ------NDCFGQE-----------------------------------LPFNNVV----SLFLPT 1203
                  |:...||                                   ||.:|.|    ||:.|:
  Rat  1218 PFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAGTAKPPTLPRSNTVASFSSLYQPS 1282

  Fly  1204 A----HGGVFGPDNTI---QAPPHTLADPEPEPEAE-VNAATAPQASALRSRMVAKARALQRQEE 1260
            .    |..|...|:.:   :..|.....|...||.| ..||........|....:::.:...|||
  Rat  1283 CQGQLHRSVSWADSAVVLEEGSPGEAHVPVEPPELEDFEAALGTDRHCQRPDAYSRSSSASSQEE 1347

  Fly  1261 ---IHSVGGNGNGNGNGNGSGNAPSTGGAAAIPIPRVPASGKRGKEAALCGSVSDGEADDDSLAF 1322
               :..:...|                    |||.|..:              |:|......|:|
  Rat  1348 KSHLEELAAGG--------------------IPIERAIS--------------SEGARPTVDLSF 1378

  Fly  1323 EDAQSRARNPVRRVNSSPEMSSSWRQSFLTNKPTPLSQEPVKTTADEPQSLLTLKKKTVQYSTKD 1387
            :.:|     |:.:.:||||:                            |:|              
  Rat  1379 QPSQ-----PLSKSSSSPEL----------------------------QTL-------------- 1396

  Fly  1388 MRVSCEAIPEEIAGSTPPSQAAALALQPESGTLPPKQHSADDVSSHVAGGSNLQAG-GSTLKLGK 1451
                     ::|.|.        |..:.:.|.|.|:        :.|...|.:..| .:|..   
  Rat  1397 ---------QDILGD--------LGDKTDIGRLSPE--------AKVRSQSGILDGEAATWS--- 1433

  Fly  1452 PPLSPGQPPLLGTGRVTSFGGTSVPQPGALAKSSSSGSNGTNVGVITSDYDNGNNGNGDMMRGRS 1516
               :||:     ..|:|      ||..|.|..||....:|                    :|.|.
  Rat  1434 ---APGE-----ESRIT------VPPEGPLPSSSPRSPSG--------------------LRPRG 1464

  Fly  1517 KTISVV------REVNNGNTRPPPASSFRNFGAAKPPINTKLCMNPSFIFMQLYTTGQLG-VTDE 1574
            .|||..      :.|...|.:...|:|    .|.|.|     .:||||:|:|||.:...| .:::
  Rat  1465 YTISDSAPSRRGKRVERDNFKSRTAAS----SAEKVP-----GINPSFVFLQLYHSPFCGDESNK 1520

  Fly  1575 PLKVGPEN-SSAVSLIDLVPPFETHKIGVLYVGQGQCNNEVEILRNSHGSARYVEFLRNIGTLVS 1638
            |:.:..|: ..:|.|:|.:|.::||||.|||||:||.::|:.||.|.|||.||.|||..:|.|:.
  Rat  1521 PILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSELAILSNEHGSYRYTEFLTGLGRLIE 1585

  Fly  1639 LKEAEQNNLFI-MLDRNGADGKFAYIWKDDILQVTFHVATLMPTNLQDDPNCNEKKSHIGNDFVK 1702
            ||:.:.:.::: .||..|.||:|.|.|.|||:|..||:||||||...|...| :||.|:|||||.
  Rat  1586 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRC-DKKRHLGNDFVS 1649

  Fly  1703 IIYNESGEEYNLNTISGQFNYACVIVEPLDLNSNRVYVKARSEISKFVCHAEYRIVSDRSAPLLA 1767
            ||||:|||::.|.||.||||:..||:.|||...|.:.::.|.::...|..:..:|||||:...:|
  Rat  1650 IIYNDSGEDFKLGTIKGQFNFVHVIITPLDYKCNLLTLQCRKDMEGLVDTSVAKIVSDRNLSFVA 1714

  Fly  1768 RQMALHANLASLVYQSVQKKHP---YASNWLERLRKLKRLRSKLIEGLNSQQKS 1818
            ||||||||:||.|:.  ::.:|   |.|.|:.|||.:||||.::.|.::....|
  Rat  1715 RQMALHANMASQVHH--RRSNPTDIYPSKWIARLRHIKRLRQRIREEVHYSNPS 1766

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gigNP_524177.1 DUF3384 40..467 CDD:288697 148/432 (34%)
HEAT repeat 484..515 CDD:293787 11/30 (37%)
Tuberin 566..882 CDD:281532 111/353 (31%)
Rap_GAP 1617..1802 CDD:280332 90/188 (48%)
Tsc2NP_036812.2 DUF3384 54..466 CDD:288697 148/432 (34%)
Tuberin 555..903 CDD:281532 111/353 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1136 18/74 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1330..1359 5/48 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1373..1392 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1405..1492 27/135 (20%)
Rap_GAP 1564..1750 CDD:280332 90/188 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1764..1793 1/3 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338256
Domainoid 1 1.000 253 1.000 Domainoid score I2013
eggNOG 1 0.900 - - E1_KOG3687
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H462
Inparanoid 1 1.050 798 1.000 Inparanoid score I482
OMA 1 1.010 - - QHG47539
OrthoDB 1 1.010 - - D341431at2759
OrthoFinder 1 1.000 - - FOG0005485
OrthoInspector 1 1.000 - - oto96034
orthoMCL 1 0.900 - - OOG6_104155
Panther 1 1.100 - - LDO PTHR10063
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5077
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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