DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gig and RAP1GAP2

DIOPT Version :9

Sequence 1:	NP_524177.1	Gene:	gig / 40201	FlyBaseID:	FBgn0005198	Length:	1847	Species:	Drosophila melanogaster
Sequence 2:	XP_011522040.1	Gene:	RAP1GAP2 / 23108	HGNCID:	29176	Length:	771	Species:	Homo sapiens

Alignment Length:	532	Identity:	114/532 - (21%)
Similarity:	201/532 - (37%)	Gaps:	134/532 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1355 PTPLSQEPVKTTADEPQSLLTLKKKTVQYSTKDMRVSCEAIPEEIAGSTPPSQAAALALQPESGT 1419
            |.|...|.|:.....||.:|   .:...|..:|        ||.:  .||.|..:::..:.|...
Human   128 PYPSIDEVVEKGGPYPQVIL---PQFGGYWIED--------PENV--GTPTSLGSSICEEEEEDN 179

  Fly  1420 LPPKQHSADDVSSHVAGGSNLQAGGSTLK-----LGKPPLSPGQPPLLGTGRVTSFGGTSVPQPG 1479
            |.|...           |..|:..|....     |||..|:     ...||  :|.|...:
Human   180 LSPNTF-----------GYKLECKGEARAYRRHFLGKDHLN-----FYCTG--SSLGNLIL---- 222

  Fly  1480 ALAKSSSSGSNGTNVGVITSDYDNGNNGNGDMMRGRSKTISVVREVNNGNTRPPPASSFRNFGAA 1544
            ::....:.|.....|                ::|.:.||:         :.|.|.|      |.:
Human   223 SVKCEEAEGIEYLRV----------------ILRSKLKTV---------HERIPLA------GLS 256

  Fly  1545 KPPINTKLCMNPSFIFMQLYTTGQLGVTDEPLKVGPENSSAVSLIDLVPPFETHKIGVLYVGQGQ 1609
            |.|...::.        :.:....:|:...|: :.|:.|..:...|......|.|.||:|....|
Human   257 KLPSVPQIA--------KAFCDDAVGLRFNPV-LYPKASQMIVSYDEHEVNNTFKFGVIYQKARQ 312

  Fly  1610 CNNEVEILRNSHGSARYVEFLRNIGTLVSLKEAE--QNNLFIMLDRNGADGKFAYIWKDDILQVT 1672
            ...| |:..|:..|..:.|||..:|..::|::.:  :..|.:...:.|.:..:. .::|  .::.
Human   313 TLEE-ELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYT-TFRD--REIM 373

  Fly  1673 FHVATLMPTNLQDDPNCNEKKSHIGNDFVKIIYNESGEEYNLNTISGQFNYACVIVE----PLDL 1733
            |||:|.:|.. ..|....::|.|||||.|.||:.|....:..:.|:..|.:|.::|:    ..:.
Human   374 FHVSTKLPFT-DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQVETPGTET 437

  Fly  1734 NSNRVYVKARSEISKF-----------------------VCHAEYRIV-SDRSAPLLARQMA--- 1771
            .|.:|.|.||.::..|                       :.:||.... ||:.|.|..|..|
Human   438 PSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALL 502

  Fly  1772 ------LHANLASLVYQSVQK---KHPYASNWLERLRKLKRLRSKLIEGL-NSQQKS------GS 1820
                  |||:..:::....::   ::.....:||..::..|:||..:|.: ..|:||      ||
Human   503 DNLHDELHAHTQAMLGLGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGGQKKSHSGGIPGS 567

  Fly  1821 ASSGIGINASAI 1832
            .|.||..|:..:
Human   568 LSGGISHNSMEV 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gig	NP_524177.1	DUF3384	40..467	CDD:288697
		HEAT repeat	484..515	CDD:293787
		Tuberin	566..882	CDD:281532
		Rap_GAP	1617..1802	CDD:280332	49/226 (22%)
RAP1GAP2	XP_011522040.1	Rap_GAP	319..498	CDD:280332	43/182 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940