DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gig and gig

DIOPT Version :10

Sequence 1:NP_524177.1 Gene:gig / 40201 FlyBaseID:FBgn0005198 Length:1847 Species:Drosophila melanogaster
Sequence 2:XP_061516960.1 Gene:gig / 1270802 VectorBaseID:AGAMI1_005977 Length:2265 Species:Anopheles gambiae


Alignment Length:2310 Identity:891/2310 - (38%)
Similarity:1217/2310 - (52%) Gaps:525/2310 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SKFKLFLKSLPAGYVG----ERTLRPEFERELRPEQPVAQRCRMLKELGDTQLHNFNLDESAITI 67
            |:.|.|.:....|.|.    :..:.||.|||||||.||.|||:.|::.|| |:....|:..|:..
Mosquito    11 SRIKQFFRMSKPGSVSSSRHDLPISPELERELRPETPVTQRCKALRDFGD-QVLTSRLEPDAVQS 74

  Fly    68 LFNLTNDLIVPNKPAETRQIALSFYKRLIHTQYKNLTIMREKFFLVIQNHEAREDLRHLLELLDT 132
            |:.||.||:|.||..|.||.||:||.|||..||..|.:||.:|:.||::|...||:.:.||:|..
Mosquito    75 LWELTKDLLVGNKLMEQRQCALAFYCRLIQGQYDRLGLMRAQFYRVIESHSEPEDISYRLEMLKL 139

  Fly   133 LTDNGKDITNFEEKIGKFMLLWIPAITEANLLTPYLDILVNLIKFNAAHLDKDILVGIVQNACDL 197
            ||:.||:|.:||::||.|:|.||..|.||.|:...|:::|||||:|||.|:...|||:|....|:
Mosquito   140 LTETGKNIQHFEKEIGAFLLDWIKPIHEAGLIDSLLELIVNLIKYNAASLEPKFLVGVVSYIFDM 204

  Fly   198 SCSVTVNEIGLQCLTILEMVIGYTIFPSEPLPQCITTLCRTVNHAPYCPSSFKIMKNLLGTQLGY 262
            :|:.......|.||::|:..|.|.|.|:|.|...|..|||.||...||..|:||||||.||.||:
Mosquito   205 TCNKQETNTILLCLSVLDCFICYAIIPNESLTLFIIILCRMVNQEAYCQHSWKIMKNLFGTALGH 269

  Fly   263 HSMKMMCSILNDRALYDDAHLLRGAVFHLNMNIFGSNI--IFQVSPMTYATNVLTAFLRALDSRQ 325
            .::..||:|||:.|.:.|..|||||:||.|:.::|.::  |...||    :.|||:|..||.||.
Mosquito   270 ATLLTMCNILNNPAFHQDDALLRGAIFHTNVGLWGISVVPILHCSP----SLVLTSFWNALKSRH 330

  Fly   326 VIVTFEVILSVRMVITK--RQLSEIIWDLICDIMSSIVSNIEYYEEVNINKDRL---HHLQINFH 385
            ||||:|||||:..:|.|  .:|:|..||:|||||:.|..|:..:        ||   |.:..:||
Mosquito   331 VIVTYEVILSMNRLIQKSGNELNEPTWDIICDIMTEISHNLAIH--------RLPADHTVVTHFH 387

  Fly   386 ENIDCIEKLLQQDRSQILGNVERIYDLIERVADRRPEASVLALIEYRSRRVTATRPDWLQVLAQF 450
            |.::.:|:||||  ..:..:.|::|.|||.|:..||||||..||:||:.:::|||.:||:.|.||
Mosquito   388 ETLNMVEQLLQQ--GTLNADPEKVYGLIEHVSAERPEASVRQLIDYRASKISATRSEWLKQLCQF 450

  Fly   451 VRRYYRMSNVNVRIKTIEALVQIMDQNRACYEEEILSRVVLVHLSHIHLESSVQVRVAVARALSN 515
            :.|:|||.|.||||..::||.:||..|||.||:|||.|:|:|||..:.||...:||.||||.|..
Mosquito   451 MDRFYRMKNSNVRIYAVQALERIMTANRAAYEDEILERIVIVHLGTVPLEKDPEVRKAVARTLIE 515

  Fly   516 FATHCDTKRCMDLLDILEALINRPFEHTRHGSSSGEGTLAEVTFGLVNNESEISDIIAAVDGLVK 580
            |..||:||||::||:|:|.|:.||:|..:                :|.:|.|..|||..||||::
Mosquito   516 FTIHCETKRCIELLEIVEKLLQRPYEENQ----------------VVRSEQEAEDIILLVDGLIR 564

  Fly   581 VFAIKLHRLPGIHALKIFNILMDHLELHYERPKIFEHISVVRYKIFAWLLKARANGSYHIGYP-- 643
            :|.:||:|||.:||::::::|:..||.||:||.:..::..:||:||||::|||||||:|||||  
Mosquito   565 LFIVKLYRLPSLHAIRVYSMLIGLLEQHYQRPHVLANVVTIRYRIFAWMMKARANGSFHIGYPDP 629

  Fly   644 -EGSTEVVKFSPYLGIDSPL------------------------------------LPQAHPTAI 671
             :|:.  |:||.|||::.|.                                    :|..:.|.|
Mosquito   630 EDGNR--VRFSHYLGLEGPYQHQSLQPQPYLSSQSTSQLNLTGAGGSEAGSKAMDRIPATNLTTI 692

  Fly   672 SIRRVCKLIVRCLEHDTDYQVFQLVIRELPKVLQNKALVQGNDIEELANTLL-----KINL---- 727
            ||:|.|::||.||:.:.|::|.|||:.|||.|:|||||:||||::.||.||.     |:.|    
Mosquito   693 SIKRGCQVIVLCLKEEKDWEVIQLVLTELPSVMQNKALIQGNDVDSLARTLYRMYTDKMQLEKLQ 757

  Fly   728 VSNNKFKRPTDEFHALVLPAIASLVIYHESLQPQQHYGIITALNSRVLTGIASVCINTMTILILE 792
            ||.|...:.:| :..|:|||::||.:||:.|.......||.||...:::.....||..:|||:||
Mosquito   758 VSANVAPKMSD-YMELILPALSSLAMYHQHLDTNTQKNIIDALKQGLISRRPHECIRMLTILLLE 821

  Fly   793 MPEALMRKLPDVLLQMSKMSDTNALATPVLEFLSLLIHLSKHLFANFTSMHNMYVFAITLPYTKP 857
            |||.||.|:.|:||::|||:.|..:|.|||||||.||.:....|.|||....|.|.|::||:|.|
Mosquito   822 MPEQLMPKMADLLLELSKMTGTKMVALPVLEFLSTLILVPSFRFGNFTMRTYMCVMAMSLPFTNP 886

  Fly   858 HRYDHYTVSLAHHVIAGWFLKCKLELRRNCVNYIKSSIQSNAKMLSSD-IVNLNSLNEDSSNRKR 921
            .|||||||||||:|:|.||:||||.:|...|.:|...::|...:...| ..:.:.:|||||.|||
Mosquito   887 FRYDHYTVSLAHYVVAAWFIKCKLPMRHQLVKFIVQGLESYVHVPFQDGSRSFSQVNEDSSERKR 951

  Fly   922 STSLTERGSRNNANAWNDLEMRPQ----------------------------------------- 945
            |:||||:.||.........:.:.|                                         
Mosquito   952 SSSLTEQSSRRRDRIQQQAQQQKQSQQQQQQQQQGQQSGHRAGVASSNASGSTASIAQSSTALPS 1016

  Fly   946 --------MNNGLRNFHAELAETCFDFLARHTYSPCPSMPKRLPAAEFLLKDGVSQTWLVGNNLV 1002
                    :|:.:..||.|||:||.||:.|||:|||..:.||||:|||||..|.|.|||||::|:
Mosquito  1017 QKVYSISPLNDDMYRFHCELADTCVDFMVRHTFSPCSGISKRLPSAEFLLSGGQSMTWLVGHDLI 1081

  Fly  1003 TITTSGCPSAPARSGLCERCAQLGKAPSISLN--------------------------------S 1035
            |||||||.....|:|||:||.|..::...:.|                                |
Mosquito  1082 TITTSGCSGVTFRNGLCDRCHQYCQSAGTASNGPGDQSKLMAPYQHHQQQHHHQHQQHHHHALLS 1146

  Fly  1036 KSLSDAA-----------PPLSPE----------------------------------------- 1048
            ||.|.|:           .|||||                                         
Mosquito  1147 KSNSSASTATTTTTVGGGQPLSPEPPFSSASSGKDSGLSGIGLGGGGDGALSAAGNGLPLTLASA 1211

  Fly  1049 --RERRYTKVSLQHSSGNESAGSTELTSSSS------------------------SNSAAAGGHP 1087
              ..:||||.||||||.||| .||:||:|||                        :|:|||....
Mosquito  1212 SSSNKRYTKASLQHSSANES-DSTDLTTSSSTSSSTAATPYPTAPHSAHGGPMVAANAAAASNRF 1275

  Fly  1088 HRQISNS--STASLDALSRRGSNPEALGSAL-GEGAHTG--------SNTSLL------------ 1129
            .||.|..  |:.||:|||||||||::....: |.|...|        ..||.|            
Mosquito  1276 FRQGSQEGYSSGSLEALSRRGSNPDSADPTIGGPGGMMGPVGGELQLQRTSSLVAPRAPPGLMAT 1340

  Fly  1130 -GNSL---SQSSVSM---------SPSSGSVVQQPV--CVRACTGWAEVLVRRPTGNVSWITRIQ 1179
             ||.|   .|.|.|:         |.|||....:||  |...|||||||.||||||..|||||||
Mosquito  1341 IGNRLILPQQLSSSLAGGVCGGGSSSSSGIGFDRPVQPCACVCTGWAEVCVRRPTGFTSWITRIQ 1405

  Fly  1180 NPITNDCFGQELPFNNVVSLFLPTAHGGVFGPD---------------------NTIQAPPHTLA 1223
            :.:::|..|.::...::.|||.|:..|||.|||                     ::...|..|:.
Mosquito  1406 SQVSHDILGGDVSLQDLTSLFSPSVGGGVIGPDYMTLGTGGHPSYSGDGLTPFGSSADIPSATMV 1470

  Fly  1224 D----PEPEPEAEVNAATA-----------------PQASALRS----RMVAKARALQRQ--EEI 1261
            |    ....||:|:..:|.                 |:|....|    .||.|..:.::.  ||.
Mosquito  1471 DRIAAAAAAPESELQPSTVGSSELLNPVPAPAPTVQPRAKVSISDEVFEMVKKTESKKKPSVEEE 1535

  Fly  1262 HSVGGN---GNGNGNGNGSGNAPSTGGAAAIPIPRVPASGKRGKEAALCGSVS------------ 1311
            |....:   .|....|.|...:.|.||:..|.||        ||:::..|:::            
Mosquito  1536 HEQSEDEELRNVLAGGGGVDPSLSGGGSGPINIP--------GKQSSTAGALASDDDASHSDDDD 1592

  Fly  1312 ---DGEAD----------DDSLAFEDAQSRARNPVRRVNSSPEMSSSWRQSFLTNKPTPLSQEP- 1362
               |||.|          :|.:.|:|...|.|.|||||||||||.:.|...||:.......|:. 
Mosquito  1593 DEEDGEEDGSDENGRKHGNDEVMFDDTDGRTRKPVRRVNSSPEMRTKWNSQFLSKAKESAGQQHQ 1657

  Fly  1363 ----------VKTTADEPQSLLTL-----------------KKKTVQYSTKDMRVSCEAIPEEIA 1400
                      |...|.:|..:.|.                 |||    ||....|||||||||||
Mosquito  1658 QHQQMDSTAIVTAGAGDPAVVATTSVVSAGLGQTVETGVMEKKK----STYGKGVSCEAIPEEIA 1718

  Fly  1401 GSTPP------------------------------------SQAAALALQ-PESGTLPP------ 1422
            |||||                                    ::|.|:... |||.||.|      
Mosquito  1719 GSTPPPPTALRMQSDPQTTAVPPPPTVRGTVTAKHQAEFGATKATAITTSLPESNTLEPIPASLV 1783

  Fly  1423 ---KQHSADD--VSSHVAGGS-----NLQAG--------------------------GSTLKL-- 1449
               |||||||  :::...|.|     .||.|                          ..:|||  
Mosquito  1784 APRKQHSADDATLAARPDGASTEVINTLQQGPIAGLPSGAMIAPIAMHPITQTSSSSALSLKLPM 1848

  Fly  1450 ----GKPPLSPG--QPPLLG---TGRVTSFGGTSVPQPGALAKSSSSGSNGTNVGVITSDYDNGN 1505
                .|||.||.  .|.|:.   :....|..||:.|...|:. ...:||.|...|::  ...:|.
Mosquito  1849 EKVTSKPPQSPVPLSPRLIARNTSNLKQSSSGTASPSFPAMG-MGGAGSIGIGSGLL--GMGSGG 1910

  Fly  1506 NGNGDMMRGRSKTISVVREVNNGNTRPPPASSFRNFGAAKPPINTKLCMNPSFIFMQLYTTGQLG 1570
            |.|.::.||||||||.|||   ..||.....|..|....:.....:..::|||:|:|||..||.|
Mosquito  1911 NDNDNLPRGRSKTISTVRE---HYTRDASKWSAANVSRMRNEHINRTVVSPSFVFLQLYHHGQFG 1972

  Fly  1571 VTDEPLKVGPENSSAVSLIDLVPPFETHKIGVLYVGQGQCNNEVEILRNSHGSARYVEFLRNIGT 1635
             ::.||.:..:...|::|:||:||||.|||||||||.||..||.|||:|.:||.||.|||.::||
Mosquito  1973 -SECPLLLDKDPEKAIALLDLIPPFEMHKIGVLYVGPGQAGNESEILKNRYGSLRYAEFLSSLGT 2036

  Fly  1636 LVSLKEAEQNNLFIMLDRNGADGKFAYIWKDDILQVTFHVATLMPTNLQDDPNCNEKKSHIGNDF 1700
            ||::|:|::.|:||.|:.||.||.|.||::|||:|:||||||||| |.:.||:|||||.||||||
Mosquito  2037 LVAIKDAKEKNIFIDLESNGKDGAFTYIYQDDIVQLTFHVATLMP-NKRQDPHCNEKKKHIGNDF 2100

  Fly  1701 VKIIYNESGEEYNLNTISGQFNYACVIVEPLDLNSNRVYVKARSEISKFVCHAEYRIVSDRSAPL 1765
            |.|:||||||||:|.||.||:|||||||||::||||||:::::.:|::.|.. |.:||||.:|||
Mosquito  2101 VTIVYNESGEEYDLKTIRGQYNYACVIVEPIELNSNRVFIRSKDDIAQHVTR-ETKIVSDHTAPL 2164

  Fly  1766 LARQMALHANLASLVYQSVQKKH--PYASNWLERLRKLKRLRSKLIEGLNS-------------- 1814
            |||||||||||||||.||::.|:  ||||||||||||:|.:||:..:..:.              
Mosquito  2165 LARQMALHANLASLVAQSLKTKNSSPYASNWLERLRKIKNIRSRYGQQQDDQRQTQQQQQQQQQQ 2229

  Fly  1815 --QQKSGSASSGIGINASAIGSDMDDQRGDFIKYT 1847
              ||..|.:::.:...||:..|.:..:..||.|||
Mosquito  2230 SLQQGGGGSANDLSSAASSSNSGISYRVDDFSKYT 2264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gigNP_524177.1 DUF3384 40..421 CDD:463376 170/387 (44%)
Tuberin 566..882 CDD:460965 160/363 (44%)
PRK12727 <1219..>1418 CDD:237182 80/318 (25%)
Rap_GAP 1617..1802 CDD:460463 123/186 (66%)
gigXP_061516960.1 None

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