DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7365 and Plb1

DIOPT Version :9

Sequence 1:	NP_001262088.1	Gene:	CG7365 / 40200	FlyBaseID:	FBgn0036939	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_620253.1	Gene:	Plb1 / 192259	RGDID:	621565	Length:	1450	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	145/430 - (33%)
Similarity:	202/430 - (46%)	Gaps:	65/430 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SQR--TSLDVAL-KNVYRPLRLLGLAFTGRSGD--DPQNVQRLQIAGKTQKSNPRTRAL------ 75
            ||:  |.|..|| .|:..||        |:..|  ||:.:  :.:|..| |..|..|..
  Rat  1008 SQKFHTQLARALWANMLEPL--------GKKMDTLDPKEL--IALACPT-KDKPFLRTFRNSNYT 1061

  Fly    76 ------LEFCDADHGPGKRSPER--PTSVHRLRPGDIDVIGAMGDSLTAGNGIFATNLLHVTVEN 132
                  :|...:|....::||..  |||||.|||.||.|:.||||.||...|...:....:....
  Rat  1062 YPIKPAIENWGSDFLCTEQSPSSKVPTSVHELRPSDIKVVAAMGDFLTTATGARPSESSSLDTPW 1126

  Fly   133 RGVVWSIGGQYDWRKYLTLPNILKEFNPNLYGYAIKDGISTDRSSRFDVAELAAMSRDMPHMAKV 197
            ||:.|||||......:.|||||||:|||::.|::..   :.:.::..:|||..|.::|||..|:.
  Rat  1127 RGLSWSIGGDGTLETHTTLPNILKKFNPSILGFSTG---TLENTAGLNVAEEGARAQDMPAQAQA 1188

  Fly   198 LVRRMQRDPRVNMTSDWKLVTLFIGNNDFCTDICYYPEPEKTVDWHERNMLKTYRYLRD----NV 258
            ||::|:..|.:|:..||||:||.|||||.|   .|..:||   ::..|..:|..::..|    .:
  Rat  1189 LVKKMKSTPTINIQEDWKLITLLIGNNDLC---LYCEDPE---NYSTREYVKYIQHALDIFYEEL 1247

  Fly   259 PRLMLNIVPAPNLRFLTNLTGLPPICYSTLRFECPCL-----------MGKGKGQLDYLEGIMKR 312
            ||:.:|:|....|..|.:..|........::..|.||           :.|..|.|......:..
  Rat  1248 PRVFINVVEVMELSGLLHDQGGKCAMPLAVQKNCSCLKRSQNLMAMQELKKVNGNLQSALSELSY 1312

  Fly   313 WIAKDFEIANREEFNTETFTINVQPFSQFQDFPRTRSGQTDTRFFSEDCFHLSQRGHAAAANSIW 377
            |         ......|.|.:.||||.:....|....|..|..||||||||.|.||||..|.::|
  Rat  1313 W---------HRYMQREDFAVTVQPFFRNTFVPLDERGGLDLTFFSEDCFHFSVRGHAEMAIALW 1368

  Fly   378 NNMLELPGHK--SGFATHLFETFRCPSEMRPFLITRENSR 415
            |||||..|.|  |...|:.....:|||...|||.|..||:
  Rat  1369 NNMLEPVGKKTTSNNFTYNRTKLKCPSPENPFLYTVRNSQ 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7365	NP_001262088.1	Phospholipase_B_like	95..385	CDD:238862	108/304 (36%)
Plb1	NP_620253.1	4 X 308-326 AA approximate repeats. /evidence=ECO:0000255	41..1407		143/427 (33%)
		Phospholipase_B_like	63..321	CDD:238862
		Phospholipase_B_like	387..681	CDD:238862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..734
		Phospholipase_B_like	733..1028	CDD:238862	9/27 (33%)
		Phospholipase_B_like	1089..1376	CDD:238862	108/304 (36%)
		Necessary for membrane localization. /evidence=ECO:0000269\|PubMed:9442065	1408..1450		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4413
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1232962at2759
OrthoFinder	1	1.000	-	-		FOG0001722
OrthoInspector	1	1.000	-	-		otm44535
orthoMCL	1	0.900	-	-		OOG6_104972
Panther	1	1.100	-	-	LDO	PTHR21325
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1449
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920