DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7365 and PLB1

DIOPT Version :9

Sequence 1:	NP_001262088.1	Gene:	CG7365 / 40200	FlyBaseID:	FBgn0036939	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_011530891.1	Gene:	PLB1 / 151056	HGNCID:	30041	Length:	1478	Species:	Homo sapiens

Alignment Length:	409	Identity:	147/409 - (35%)
Similarity:	210/409 - (51%)	Gaps:	66/409 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DDPQNVQRLQIAGKTQK--------------SNPRTRAL--LEFCDADHGPGKRSPER------P 93
            |:|.:|:.    |:..|              ||..||..  .:..:...|...|.|::      |
Human   340 DEPLSVKH----GRPMKCPSQESPYLFSYRNSNYLTRLQKPQDKLEVREGAEIRCPDKDPSDTVP 400

  Fly    94 TSVHRLRPGDIDVIGAMGDSLTAGNGIFAT--NLLHVTVENRGVVWSIGGQYDWRKYLTLPNILK 156
            ||||||:|.||:||||:|||||||||..:|  |:|.|..:.||:.||:||..:.....||.|||:
Human   401 TSVHRLKPADINVIGALGDSLTAGNGAGSTPGNVLDVLTQYRGLSWSVGGDENIGTVTTLANILR 465

  Fly   157 EFNPNLYGYAIKDGISTDRSSRFDVAELAAMSRDMPHMAKVLVRRMQRDPRVNMTSDWKLVTLFI 221
            ||||:|.|:::..|..|..::..:.|.....:.|:|..|:.||..|:.|.|::...|||::||||
Human   466 EFNPSLKGFSVGTGKETSPNAFLNQAVAGGRAEDLPVQARRLVDLMKNDTRIHFQEDWKIITLFI 530

  Fly   222 GNN---DFCTDICYYPEPEKTVDWHERNMLKTYRYLRDNVPRLMLNIVPA---PNLRFLTNLTGL 280
            |.|   |||.|:.:| .|:...|    |:.|....|...|||..:|:|..   .|||.|
Human   531 GGNDLCDFCNDLVHY-SPQNFTD----NIGKALDILHAEVPRAFVNLVTVLEIVNLREL------ 584

  Fly   281 PPICYS---------TLRFECPCLM--GKGKGQLDYLEGIMKRWIAKDFEIANREEFNT-ETFTI 333
                |.         .||..|||::  .....:|..|....|::..|..::.....::| |.||:
Human   585 ----YQEKKVYCPRMILRSLCPCVLKFDDNSTELATLIEFNKKFQEKTHQLIESGRYDTREDFTV 645

  Fly   334 NVQPFSQFQDFPRTRSGQTDTRFFSEDCFHLSQRGHAAAANSIWNNMLELPGHKSGFATHLFE-- 396
            .||||.:..|.|:|..|..|..||:.||||.|.:.|:.||:::||||||..|.|:  ..|.||
Human   646 VVQPFFENVDMPKTSEGLPDNSFFAPDCFHFSSKSHSRAASALWNNMLEPVGQKT--TRHKFENK 708

  Fly   397 -TFRCPSEMRPFLITRENS 414
             ...||::::|||.|.:||
Human   709 INITCPNQVQPFLRTYKNS 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7365	NP_001262088.1	Phospholipase_B_like	95..385	CDD:238862	120/309 (39%)
PLB1	XP_011530891.1	Phospholipase_B_like	61..337	CDD:238862
		Phospholipase_B_like	402..697	CDD:238862	120/309 (39%)
		Phospholipase_B_like	749..1044	CDD:238862
		Phospholipase_B_like	1105..1391	CDD:238862
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149758
Domainoid	1	1.000	165	1.000	Domainoid score	I3917
eggNOG	1	0.900	-	-		E1_KOG3670
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1232962at2759
OrthoFinder	1	1.000	-	-		FOG0001722
OrthoInspector	1	1.000	-	-		otm40400
orthoMCL	1	0.900	-	-		OOG6_104972
Panther	1	1.100	-	-	LDO	PTHR21325
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3425
SonicParanoid	1	1.000	-	-		X1449
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740