DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and GLR1.3

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	501	Identity:	105/501 - (20%)
Similarity:	173/501 - (34%)	Gaps:	132/501 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MGENGTLSPVTELPMDVDASEA----GFDADAPVETLETINRKKPKLREMLDWIGGKHLRIATLE 91
            :..||:.|....|....:..|.    |..|.:|..| ..|:..:.||| :|.....:..|:..:|
plant   395 LNSNGSFSNRRHLSSTHNKLETIIWPGGSAQSPKGT-SLIDSDRKKLR-VLVTSSNRFPRLMKVE 457

  Fly    92 DFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEV-VVP------QDNI---IGSPSD-FDR 145
            ..|::...::|         .|.|..|......|.||| .:|      .||:   :.|..| :|.
plant   458 TDPVTNELIVE---------GFCIEVFRASISPFNYEVEYIPWLNGSNYDNLAYALHSQKDKYDA 513

  Fly   146 SLIEMV---NSST-VDLAAAF------IPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSG 200
            ::.::.   |.|| ||....|      |.::.::..:|::...|.|
plant   514 AVGDITITSNRSTYVDFTLPFTEMGLGIVAVKERSMWVFFQPLTPD------------------- 559

  Fly   201 LLAPFEFWVWILILVSLLAVGPIIYALIILRNR-LTGDGQQTPYSLGHCAWF-----VYGALMKQ 259
                    :||......:..|.|::.:....|: ..|   ..|..:|...||     ||....|.
plant   560 --------LWITSAFFFVLTGVIVWLIERAENKEFQG---SWPQQIGVVLWFGFSTLVYAHREKL 613

  Fly   260 GSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGG 324
            ...||      |.:...|...:.|||:.|||.||:.:|:.:  :.:|:       |:.:|....|
plant   614 KHNLS------RFVVTVWVFAVLILTASYTATLTSMMTVQQ--IRFNS-------NEDYVGHLSG 663

  Fly   325 GVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLY 389
            .:...:..|:.||..:..:..|:.|.                                 |...|.
plant   664 SLIANVALTSSSLRAMRSLGLNSAAD---------------------------------YAQALL 695

  Fly   390 RKTVSF-SDEKVHCPFAMAKEP---FLKKKRT------FAYPIGSNLSQLFDPELLHLVESGIVK 444
            .||||| .||..:....:.:.|   |:.|.::      |.:..|..|......|:..|..|..:.
plant   696 NKTVSFVVDELPYLKVVLGENPTHFFMVKTQSTTNGFGFMFQKGFELVPNVSREISKLRTSEKLN 760

  Fly   445 HLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAV 490
            .:.||...:.  .|.....|...:........:.|:...||.||||
plant   761 EMEKRWFDNQ--LPYTTDDTSNPITLYRFRGLFIIIGVSFAFALAV 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	78/390 (20%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	3/9 (33%)
		ANF_receptor	57..385	CDD:279440
		GluR_Plant	438..767	CDD:270404	86/416 (21%)
		Lig_chan	559..798	CDD:278489	59/318 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910