DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and GLR2.1

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_198062.2	Gene:	GLR2.1 / 832768	AraportID:	AT5G27100	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	584	Identity:	117/584 - (20%)
Similarity:	204/584 - (34%)	Gaps:	138/584 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NGTLSPVTELPMDVDAS---EAGF---------DADAPVETLETINRKKPKLREMLDWIG----- 81
            ||.|.|.....::|:..   ..||         :.|....:..|.:..:.:||.:: |.|
plant   378 NGELQPSVFEIVNVNGQGGRTIGFWMKEYGLFKNVDQKPASKTTFSSWQDRLRPII-WPGDTTSV 441

  Fly    82 ---------GKHLRIA-----TLEDFPLSYTEVLENGTRVGHGVSFQIIDFLKK-----KFNFTY 127
                     ||.|:|.     |.:.|..:..:.:.|.| :..|.|   ||:.:.     .::.:|
plant   442 PKGWEIPTNGKRLQIGVPVNNTFQQFVKATRDPITNST-IFSGFS---IDYFEAVIQAIPYDISY 502

  Fly   128 EVVVPQDNIIGSPSDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRP 192
            :.:..||      ..:| :|:..|.....|...|.....|::..:|.:|......|..::|..:.
plant   503 DFIPFQD------GGYD-ALVYQVYLGKYDAVVADTTISSNRSMYVDFSLPYTPSGVGLVVPVKD 560

  Fly   193 RESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLT----GDGQQTPYSLGHCAWFVY 253
            ....|.:..|.|....:|::.|:|...:|.:::   :|.:|:.    |.||   |.|....||.:
plant   561 SVRRSSTIFLMPLTLALWLISLLSFFIIGLVVW---VLEHRVNPDFDGPGQ---YQLSTIFWFSF 619

  Fly   254 GALMKQGSTLSP----IADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTK 314
            ..::     .:|    ::...|::...|:..:.:||..|||:|.:.||..........:|.:|.|
plant   620 SIMV-----FAPRERVLSFWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLHPTVTNINSLLAK 679

  Fly   315 NKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNY------AVFSDETNDTYNLQNYVEKNGYVFV 373
                    |..|.|      :|..:|.|:..:.:      :..|.|..|....:...|......:
plant   680 --------GESVGY------QSSFILGRLRDSGFSEASLVSYGSPEHCDALLSKGQAEGGVSAVL 730

  Fly   374 RDRPAINIMLYRDYLYRKTVSFSDEKVHC-PFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHL 437
            .:.|.:.|.|.:               :| .:.|.:.||......|.:||||.|.......:|.:
plant   731 MEVPYVRIFLGQ---------------YCNKYKMVQTPFKVDGLGFVFPIGSPLVADISRAILKV 780

  Fly   438 VESGIVKHLSKRNL-PSAEICPQDLGGTE-------RQLRNGDLMMTYYIMLAGFATALAVFSTE 494
            .||.....|..... |..|.||..|...:       |||......:.:.:.......||..|..:
plant   781 EESNKANQLENAWFKPIDESCPDPLTNPDPNPSVSFRQLGFDSFWVLFLVAAIVCTMALLKFVYQ 845

  Fly   495 LMFRYVNSRQEANKWAR-------------------HGIGRTPNGQSVAPSRWLRGWRRLNSGH 539
            .:....|.|.....|.:                   .|.|...|||        .|...:|:|:
plant   846 FLKENPNQRNLRVLWEKFNEPDQKSYIKDVTKCQCSSGQGMPKNGQ--------EGANAVNNGN 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	78/378 (21%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor	49..411	CDD:107361	7/32 (22%)
		ANF_receptor	49..392	CDD:279440	4/13 (31%)
		GluR_Plant	452..794	CDD:270404	81/392 (21%)
		Periplasmic_Binding_Protein_Type_2	478..>685	CDD:304360	50/236 (21%)
		Lig_chan	576..835	CDD:278489	62/298 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910