DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir76b and GLR1.1

DIOPT Version :9

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_187061.1 Gene:GLR1.1 / 819566 AraportID:AT3G04110 Length:808 Species:Arabidopsis thaliana


Alignment Length:536 Identity:109/536 - (20%)
Similarity:186/536 - (34%) Gaps:169/536 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 DVDASEAGFDADAPVETLETINRKKPKLREMLDWIGG------------------KHLRIATLED 92
            |:..|:..|.:    ||.|.:|..:.|.|.:..|.||                  :|..:|  |.
plant   359 DIQISDNKFIS----ETFEIVNIGREKQRRIGLWSGGSFSQRRQIVWPGRSRKIPRHRVLA--EK 417

  Fly    93 FPLSYTEVLEN-GTRVGHGVSFQ---------IIDFLKKKFN-----FTYEV-VVP----QDNII 137
            .......||.. |.:|.|.||.:         :..|..:.|.     |.||: .:|    .||: 
plant   418 GEKKVLRVLVTAGNKVPHLVSVRPDPETGVNTVSGFCVEVFKTCIAPFNYELEFIPYRGNNDNL- 481

  Fly   138 GSPSDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLL 202
                    :.:........|.|...|...|::..:|.::....|.|..|:.::  ::|.......
plant   482 --------AYLLSTQRDKYDAAVGDITITSNRSLYVDFTLPYTDIGIGILTVK--KKSQGMWTFF 536

  Fly   203 APFEFWVWILILVSLLAVGPIIYALIILRN---RLTGD-GQQTPYSLGHCAWFVYGALM-KQGST 262
            .|||..:|:......:..|.:::  ::.|:   ...|. |||    |....||.:..:: .....
plant   537 DPFEKSLWLASGAFFVLTGIVVW--LVERSVNPEFQGSWGQQ----LSMMLWFGFSTIVFAHREK 595

  Fly   263 LSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTV------------NDILTKN 315
            |..:  |:|.|...|...:.||||.|:||||:..|:|:..|.:..|            ..|....
plant   596 LQKM--SSRFLVIVWVFVVLILTSSYSANLTSTKTISRMQLNHQMVFGGSTTSMTAKLGSINAVE 658

  Fly   316 KHFVSMRGGGVEYAIRTTNESLSMLNRMIQN--NYAVFSDETNDTYNLQNYVEKNGYVFVRDRPA 378
            .:...:|.|.:.:.|   || :..|:.:|.|  |..|.:|...:|         ||:.|      
plant   659 AYAQLLRDGTLNHVI---NE-IPYLSILIGNYPNDFVMTDRVTNT---------NGFGF------ 704

  Fly   379 INIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIV 443
                     :::|                               ||:|......|:..|...|::
plant   705 ---------MFQK-------------------------------GSDLVPKVSREIAKLRSLGML 729

  Fly   444 KHLSKR---NLPSAEI--CPQDLGGTE-----------RQLRNGDLMMTYYIMLAGFATALAVFS 492
            |.:.|:   .|.|..:  ..:::..|.           |:||.       ..::||.|..|.   
plant   730 KDMEKKWFQKLDSLNVHSNTEEVASTNDDDEASKRFTFRELRG-------LFIIAGAAHVLV--- 784

  Fly   493 TELMFRYVNSRQEANK 508
              |.....::|||.::
plant   785 --LALHLFHTRQEVSR 798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Periplasmic_Binding_Protein_Type_2 83..437 CDD:304360 79/392 (20%)
GLR1.1NP_187061.1 PBP1_GABAb_receptor 31..397 CDD:107361 12/41 (29%)
ANF_receptor 45..377 CDD:279440 6/21 (29%)
Periplasmic_Binding_Protein_Type_2 421..737 CDD:304360 80/393 (20%)
Lig_chan 542..781 CDD:278489 61/312 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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