DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and GLR2.2

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	579	Identity:	119/579 - (20%)
Similarity:	200/579 - (34%)	Gaps:	143/579 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AAALCVACPPLNDSPPTNLIQMGENGTLSPVTELPMDVDASEAGFDADAP--VETLETINRK--- 69
            |.|:.:....:|:...:| :..|:|     |:||      ...|.....|  ::|:.|:..|
plant   319 ALAMAIEDAGINNMTFSN-VDTGKN-----VSEL------DGLGLSQFGPKLLQTVSTVQFKGLA 371

  Fly    70 ----------KPKLREMLDWIG-----------GKHL---------RIATLEDFP--LSYT---- 98
                      :|.:.|:::.||           |..|         .|.||..:|  |.:.
plant   372 GDFHFVSGQLQPSVFEIVNMIGTGERSIGFWTEGNGLVKKLDQEPRSIGTLSTWPDHLKHIIWPG 436

  Fly    99 ---------EVLENGTRVGHGVSFQI-----------------------IDFLK-----KKFNFT 126
                     |:..||.::..||..:|                       |||.:     ..::.:
plant   437 EAVSVPKGWEIPTNGKKLRIGVPKRIGFTDLVKVTRDPITNSTVVKGFCIDFFEAVIQAMPYDVS 501

  Fly   127 YEVVVPQDNIIGSPSDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQR 191
            || ..|.:...|.|:.....|:..|.....|........|:::.|||.::...:..|..::|..:
plant   502 YE-FFPFEKPNGEPAGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGVGLIVPLK 565

  Fly   192 PRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLTGDGQ-QTPYSLGHCAWFVYGA 255
            ..........|.|....:|:..||....||..::.   |.:|:..|.: ...|......||.:..
plant   566 DEVKRDKFSFLKPLSIELWLTTLVFFFLVGISVWT---LEHRVNSDFRGPANYQASTIFWFAFST 627

  Fly   256 LMKQGSTLSP----IADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNK 316
            ::     .:|    ::...|.|..||:..:.:||..|||:|.:.||..:......:::.:|
plant   628 MV-----FAPRERVLSFGARSLVVTWYFVLLVLTQSYTASLASLLTSQQLNPTITSMSSLL---- 683

  Fly   317 HFVSMRGGGVEYAIRTTNESLSMLNR--MIQNNYAVFSDETNDTYNLQNYVEKNGYVFVR--DRP 377
            |    ||..|.|  :.|:..|..||.  ..|::...| |...:...|.....|||.|...  ..|
plant   684 H----RGETVGY--QRTSFILGKLNETGFPQSSLVPF-DTAEECDELLKKGPKNGGVAAAFLGTP 741

  Fly   378 AINIMLYRDYLYRKTVSFSDEKVHC-PFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESG 441
            .:.:.|.:               :| .:.|.:|||......|.:||||.|.......:|.:.||.
plant   742 YVRLFLGQ---------------YCNTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVAESP 791

  Fly   442 IVKHLSKRNLPSAE-ICPQDLGG-------TERQLRNGDLMMTYYIMLAGFATALAVFS 492
            ....|........| .||..:..       |..||..|.....:.::......||..|:
plant   792 KAVELEHAWFKKKEQSCPDPVTNPDSNPTVTAIQLGVGSFWFLFLVVFVVCVLALGKFT 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	87/415 (21%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	20/104 (19%)
		ANF_receptor	47..392	CDD:279440	16/84 (19%)
		HisJ	438..>587	CDD:223904	26/149 (17%)
		GluR_Plant	452..801	CDD:270404	81/383 (21%)
		Lig_chan	582..819	CDD:278489	62/270 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910