DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and GLR2

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	456	Identity:	105/456 - (23%)
Similarity:	177/456 - (38%)	Gaps:	111/456 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 WI---GGKHLRI-----ATLEDFPLSYT-----------EVLENGTR-VGHGVSFQIIDFLKKKF 123
            ||   .|:.|||     |:.:||.....           :|.|...: :.:.|..:.|.|.....
plant   461 WIFRNNGRRLRIGVPDRASFKDFVSRVNGSSNKVQGYCIDVFEAAVKLLSYPVPHEFIFFGDGLT 525

  Fly   124 NFTYEVVVPQDNIIGSPSDFDRSL--IEMVNSST--VDLAAAFIPSLSDQRSFVYYSTTTLDEGE 184
            |..|..:|   |.:.:..|||..:  |.:|...|  ||....:|.|    ...|....|.|:|..
plant   526 NPNYNELV---NKVTTGVDFDAVVGDIAIVTKRTRIVDFTQPYIES----GLVVVAPVTRLNENP 583

  Fly   185 WIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLTGDGQQTP-YSLGHC 248
            |              ..|.||...:|.:.....:.||..|:   ||.:|:..:.:..| ..:...
plant   584 W--------------AFLRPFTLPMWAVTASFFVIVGAAIW---ILEHRINDEFRGPPRRQIITI 631

  Fly   249 AWFVYGALM--KQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDI 311
            .||.:..:.  .:.:|:|.:.   |::...|...:.|:||.|||:||:.||:.:...|...|:.:
plant   632 LWFTFSTMFFSHRETTVSTLG---RMVLLIWLFVVLIITSSYTASLTSILTVQQLNSPIKGVDTL 693

  Fly   312 LTKNKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETN-------DTYNLQNYVE--K 367
            ::..        |.:.:.:.:..|           ||  .:||.|       ...:.:.|..  :
plant   694 ISST--------GRIGFQVGSFAE-----------NY--MTDELNIASSRLVPLASPEEYANALQ 737

  Fly   368 NGYV--FVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLF 430
            ||.|  .|.:||.|::.|            ||   :|.||:..:.|.:....||:|..|.|:...
plant   738 NGTVAAIVDERPYIDLFL------------SD---YCKFAIRGQEFTRCGWGFAFPRDSPLAVDM 787

  Fly   431 DPELLHLVESGIVKHLSKRNLPSAEICPQDLG---GTERQLRNGDLMMTYY--IMLAGFATALAV 490
            ...:|.|.|:|.::.:..|.| |...|....|   |...||.    :.:::  .::.|.|..:|:
plant   788 STAILGLSETGELQKIHDRWL-SKSNCSSPHGSQSGDSEQLN----VHSFWGMFLVVGIACLVAL 847

  Fly   491 F 491
            |
plant   848 F 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	87/388 (22%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361
		GluR_Plant	468..808	CDD:270404	91/402 (23%)
		Lig_chan	594..843	CDD:306551	66/295 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910