DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and gria1a

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	402	Identity:	85/402 - (21%)
Similarity:	157/402 - (39%)	Gaps:	79/402 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEFWVWILILVSLLAV 220
            |:|.|.:.....:...:.:|...:..|..||: ::|.:|..| ...|.|..:.:|:.|:.:.:.|
Zfish   485 DVAVAPLTITLVREEVIDFSKPFMSLGISIMI-KKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGV 548

  Fly   221 GPIIYALIILRNRLT---------------------------GDGQQ----------TPYSLGHC 248
            ..:::    |.:|.:                           |..||          ..:.:.:.
Zfish   549 SVVLF----LVSRFSPYEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNS 609

  Fly   249 AWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILT 313
            .||..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|..:..|:..
Zfish   610 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 674

  Fly   314 KNKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEK-NGYVFVR--D 375
            :.:         :.|.......:.....|   :..|||.       .:.:|::. :..|||:  |
Zfish   675 QTE---------IAYGTLDAGSTKEFFRR---SKIAVFE-------KMWSYMKSADPSVFVKTTD 720

  Fly   376 RPAINIMLYRD---YLYRKTVS-FSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLH 436
            ...:.:...:.   ||...|:: :.:::..|...........|....|.|.||.|....:..:|.
Zfish   721 EGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLK 785

  Fly   437 LVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMT-----YYIMLAGFATALAVFSTELM 496
            |.|.|::..|..:.......|..  ||.:.:.:...|.::     :||::.|...|:.|...|..
Zfish   786 LNEQGLLDKLKNKWWYDKGECGS--GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFC 848

  Fly   497 FRYVNSRQEANK 508
            ::   ||.|:.:
Zfish   849 YK---SRTESRR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	68/324 (21%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141
		ANF_receptor	36..369	CDD:279440
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	72/344 (21%)
		Lig_chan	536..836	CDD:278489	66/324 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840