DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and Grid2

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_077355.2 Gene:Grid2 / 79220 RGDID:68368 Length:1007 Species:Rattus norvegicus


Alignment Length:597 Identity:142/597 - (23%)
Similarity:230/597 - (38%) Gaps:102/597 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 VACPPLNDSPPTNLIQMGENGTLSPVTELPMDVDASEAGFDADAPVETL-----ETINRKKPKL- 73
            ::|...|..|......|.|......|..|..|::..|.|.:.:...|.|     |.:.|...|| 
  Rat   353 LSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLG 417

  Fly    74 --------------REMLDWIGGKHLRIATLEDFPLSYTEVLEN---GTRVGHGVSFQIIDFLKK 121
                          :::.:.:.|..||:.|:.:.|  :..|.||   ..:...|.|..::|.|..
  Rat   418 CWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEP--FVMVSENVLGKPKKYQGFSIDVLDALSN 480

  Fly   122 KFNFTYEVVVPQDNIIGSPSDFD--RSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGE 184
            ...|.||:.|..|:..|||.:..  ..|:..:.....|:..:.:....|:.:.|.::|..:|...
  Rat   481 YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSV 545

  Fly   185 WIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLTGDGQQTPYSLGHCA 249
            .:: ::|..::......||||:..:|..|..::|.||.::|.|..|.......|..|..:|.:..
  Rat   546 GVL-LRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSM 609

  Fly   250 WFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLT-------------LSKF 301
            |||||:.::||..:.....:||::...||:|..|:.|.|||||.||||             |||.
  Rat   610 WFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQ 674

  Fly   302 T-LPYNTVNDILTKNKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYV 365
            | :||.||.|    :..:..:|..|:....|  :...|.:.|||..:    :...|:....|..:
  Rat   675 TDIPYGTVLD----SAVYQHVRMKGLNPFER--DSMYSQMWRMINRS----NGSENNVLESQAGI 729

  Fly   366 EK---NGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLS 427
            :|   ..|.||.|...:..:...|             ..|.|.........:....|...||...
  Rat   730 QKVKYGNYAFVWDAAVLEYVAIND-------------PDCSFYTVGNTVADRGYGIALQHGSPYR 781

  Fly   428 QLFDPELLHLVESGIVKHLSKRNLPSAEICPQDL-GGTERQLRNG-----DLMMTYYIMLAGFAT 486
            .:|...:|.|.:||.:..|..:..|....|  || ...:.:.:.|     .|...:.|:.||...
  Rat   782 DVFSQRILELQQSGDMDILKHKWWPKNGQC--DLYSSVDAKQKGGALDIKSLAGVFCILAAGIVL 844

  Fly   487 A--LAVFSTELMFRYVNSRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLN-------SGHGQL 542
            :  :||..|              .|:|....|.|:.:...........||:|       |.|.|.
  Rat   845 SCLIAVLET--------------WWSRRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQF 895

  Fly   543 LGASTHGQNVTP 554
               ||...::||
  Rat   896 ---STSSIDLTP 904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 25/113 (22%)
Lig_chan 209..458 CDD:459656 70/265 (26%)
Grid2NP_077355.2 Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424 24..345
Periplasmic_Binding_Protein_type1 28..429 CDD:471960 16/75 (21%)
PBP2_iGluR_delta_2 440..806 CDD:270449 100/391 (26%)
Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453 921..991
PDZ-binding. /evidence=ECO:0000250 1005..1007
Blue background indicates that the domain is not in the aligned region.

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