DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and grin2aa

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:XP_021329529.1 Gene:grin2aa / 563297 ZFINID:ZDB-GENE-070424-129 Length:1460 Species:Danio rerio


Alignment Length:496 Identity:110/496 - (22%)
Similarity:184/496 - (37%) Gaps:133/496 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 HLRIATLEDFPLSYTEVLE------------------NGTRVGHGVSFQ------IIDFLKK--- 121
            ||.|.|||:.|....|.:|                  :.|..|.|...:      .||.|||   
Zfish   402 HLTIVTLEEKPFVIVENVERLTGTCMRNSVPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIAR 466

  Fly   122 KFNFTYEVVVPQDNIIGSPSD--FDRSLIEMVNSSTVDLAAAFIPSLSDQRSFVY-YSTTTLDEG 183
            ...|||::.:..:...|...:  ::..:.|:||...|....:.  :::::||.|. :|...::.|
Zfish   467 NVKFTYDLYLVTNGKHGKKINNVWNGMVGEVVNKKAVMAVGSL--TINEERSEVIDFSVPFVETG 529

  Fly   184 EWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPI-------IYALIILRNRLTGDGQQT 241
            ..:|| .|...:.|.|..|.||...||:::.|.||.|..:       |..|...||...|.....
Zfish   530 ISVMV-SRSNGTVSPSAFLEPFSASVWVMMFVMLLLVTAMAVFMFEYISPLGFNRNLAQGKDPHG 593

  Fly   242 P-YSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILTSFYTANLTAF--------- 295
            | :::|...|.::|.:......: :|...:::.:.:.|..|..|..:.|||||.||         
Zfish   594 PSFTMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 658

  Fly   296 ---LTLSKFTLPYN--------TV-NDILTKN--KHFVSMRGGGVEYAIRTTNESLSMLNRMIQN 346
               |:..||..||:        || |....:|  |::..|....|:|.....|::|..|      
Zfish   659 VTGLSDKKFQSPYSYSPPFRFGTVPNGSTERNIRKNYPDMHQYMVKYHQTGVNDALVSL------ 717

  Fly   347 NYAVFSDETNDTYNLQNYVEKNGYV--FVRDRPAINIMLYRD-----------YLYRKTVSFSDE 398
                                |.|.:  |:.|...:|.|..||           |::..|      
Zfish   718 --------------------KTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATT------ 756

  Fly   399 KVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKRNLPSAEICPQDLGG 463
                .:.:|    |:|...:..|:        |..:|.::..|.::.|..:.|..  ||..:...
Zfish   757 ----GYGIA----LQKGSLWKRPV--------DLAILAIIGDGEMEELEAQWLTG--ICHNEKNE 803

  Fly   464 T-ERQLRNGDLMMTYYIMLAGFATALAVFSTELMF----RY 499
            . ..||...::...:|::......:|..|..|.:|    ||
Zfish   804 VMSSQLDVDNMAGVFYMLATAMGLSLITFVWEHLFYWRLRY 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 32/137 (23%)
Lig_chan 209..458 CDD:459656 62/293 (21%)
grin2aaXP_021329529.1 PBP1_iGluR_NMDA_NR2 33..384 CDD:380601
PBP2_iGluR_NMDA_Nr2 400..799 CDD:270436 101/449 (22%)
NMDAR2_C 836..1460 CDD:463148 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

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