DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and grik1b

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	481	Identity:	106/481 - (22%)
Similarity:	184/481 - (38%)	Gaps:	92/481 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LETINRKKPKLREMLDWIGGKHLRIATL----------EDFPLSYTEVLENGTRVGHGVSFQIID 117
            |...:..|.|...:.|.:..:.|.:.|:          .|.||...:..|.          ..:|
Zfish   452 LNLTDSNKDKNTNVTDSMANRTLIVTTILENPYVMYKKSDKPLYGNDRFEG----------YCLD 506

  Fly   118 FLKKKFN---FTYEVVVPQDNIIGSPSD------FDRSLIEMVNSSTVDLAAAFIPSLSDQRSFV 173
            .||:..|   |:|||.:..|...|:.:|      ..|.||:.|    .|||.|.:       :..
Zfish   507 LLKELSNILGFSYEVKLVTDGKYGAQNDKGEWNGMVRELIDHV----ADLAVAPL-------TIT 560

  Fly   174 YYSTTTLDEGEWIMVM------QRPRESASG-SGLLAPFEFWVWILILVSLLAVGPIIYALIILR 231
            |.....:|..:..|.:      .:|..:..| ...|.|....:|:.:|::.|.|..:::.:.
Zfish   561 YVREKVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIA--- 622

  Fly   232 NRLT-------------GDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITI 283
             |.|             .|..:..::|.:..||..||||:|||.|.|.|.|||::...||.|..|
Zfish   623 -RFTPYEWYNPHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 686

  Fly   284 LTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNY 348
            :.|.|||||.||||:.:...|.::.:|:..:.|         :||.......:::...:...:.|
Zfish   687 IISSYTANLAAFLTVERMDSPIDSADDLAKQTK---------IEYGAVRDGSTMTFFKKSKISTY 742

  Fly   349 A---VFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDY---LYRKTVSFSDEKVHCPFAMA 407
            .   .|.....:|..::|           :|..|..:|..||   :...::.:..:: :|.....
Zfish   743 EKMWAFMSSRKNTALVKN-----------NREGIQRVLTTDYALLMESTSIEYISQR-NCNLTQI 795

  Fly   408 KEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGD 472
            ......|......||||.........:|.|.|.|.: |:.|........||::.......|...:
Zfish   796 GGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKL-HMMKEKWWRGNGCPEEDSKEASALGVEN 859

  Fly   473 LMMTYYIMLAGFATALAVFSTELMFR 498
            :...:.::.||...::.|...|.:::
Zfish   860 IGGIFIVLAAGLVLSVFVAIGEFIYK 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	90/398 (23%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	1/2 (50%)
		ANF_receptor	80..423	CDD:279440
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	95/415 (23%)
		Lig_chan	602..871	CDD:278489	67/294 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591361
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840