Protein Alignment Ir76b and grin2bb

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 725
• Identity: 147/725 - (20%)
• Similarity: 262/725 - (36%)
• Gaps: 210/725 - (28%)

  Fly     4 GIELLVAAALCVACPPLN----DSPPTNLIQMGENGT-----------------LSPVTELPMDV 47
            |:|..|..|:.:.....:    |..|..|::.|.:|.                 |..||....::
Zfish   362 GLEARVRDAVAIIAMATSTMMLDRGPHTLLKSGCHGAPDKKGSKSGNPNEVLRYLMNVTFEGRNL 426

  Fly    48 DASEAGFDADAPVETLETINRKKPKLREMLDWIGGK-----------------------HLRIAT 89
            ..||.||... |...:..:|::: :...:..|..|.                       ||.|.|
Zfish   427 SFSEDGFQMH-PKLVIILLNKER-QYERVGKWENGSLAMKYHVWPRFELYSDAEEREDDHLSIVT 489

  Fly    90 LEDFPLSYTEVLE--NGT--------------------------RVGHGVSFQIIDFLKKKFNFT 126
            ||:.|....|.::  :||                          |...|....|:..:.|...||
Zfish   490 LEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKLQNLTGDSGIYIKRCCKGFCIDILKKIAKSVKFT 554

  Fly   127 YEVVVPQDNIIGSPSDFDRSLIEMVNSSTVDLAAAFIPSL--SDQRSFVY-YSTTTLDEGEWIMV 188
            |::.:..:...|  ...:.:...||....:..|...:.||  :::||.|. :|...::.|..:||
Zfish   555 YDLYLVTNGKHG--KKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMV 617

  Fly   189 MQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILR-------NRLTGDGQQ---TPY 243
             .|...:.|.|..|.||...||:::.|.||.|..:  |:.:..       ||...||::   ..:
Zfish   618 -SRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV--AVFVFEYFSPVGYNRCLADGREPGGPSF 679

  Fly   244 SLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNT 307
            ::|...|.::|.:......: :|...:::::.:.|..|..|..:.|||||.||:...::......
Zfish   680 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVTG 744

  Fly   308 VNDILTKNKH---------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQN 363
            ::|  .|.:|         |.::..|..|              |.|:|||........ :::.:|
Zfish   745 LSD--KKFQHPNDFSPPFRFGTVPNGSTE--------------RNIRNNYKEMHSYMT-SFHQKN 792

  Fly   364 YVE-----KNGYV--FVRDRPAINIMLYRD-----------YLYRKTVSFSDEKVHCPFAMAKEP 410
            ..|     |:|.:  |:.|...:|.|..||           |:: .|..:.       .|:.|:.
Zfish   793 VNEALHSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIF-ATTGYG-------IAIQKDS 849

  Fly   411 FLKKKRTFAYPIGSNLSQLFD----PELLHLVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNG 471
            ..|:....|      :.|||.    .||..|..:||. |..|..:.|:::...::.|
Zfish   850 GWKRAVDLA------ILQLFGDGEMEELEALWLTGIC-HNEKNEVMSSQLDVDNMAG-------- 899

  Fly   472 DLMMTYYIMLAGFATALAVFSTELMFRY--------VNSRQEANKWA--------RHGIGRTPNG 520
                .:|::.|..|.:|..|..|.:|.:        |.|.:....::        .||:....|.
Zfish   900 ----VFYMLGAAMALSLITFIAEHLFYWQLRFCFMGVCSGKPGMTFSISRGIYSCIHGVQIEENK 960

  Fly   521 QSV-APSRWLRGWRRLNSGHGQLLGASTHGQNVTPPPPYQSIFNGGSHGDP-------------- 570
            .:: :||..::  ..:|:.|..:|......:|:|..|        |.:|.|
Zfish   961 SALNSPSATMK--MNMNNTHSNILRLLRTAKNMTSVP--------GVNGSPHSALDYSHRESAVY 1015

  Fly   571 -LNRWRRPLA 579
             ::..||.||
Zfish  1016 DISEHRRSLA 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	30/162 (19%)
		Lig_chan	209..458	CDD:459656	63/290 (22%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	20/104 (19%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	96/436 (22%)
		NMDAR2_C	919..1770	CDD:463148	21/117 (18%)