DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and grik2

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	522	Identity:	106/522 - (20%)
Similarity:	195/522 - (37%)	Gaps:	112/522 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TELPMDV-DASEAGFDADA---PVETLETINRKKPKLREMLDWIGGKHLRIATL----------E 91
            |:..:|| ...|.|.:...   |...|.....:|.|...:.|.:..:.|.::|:          .
Zfish   385 TDFDLDVISLKEEGLEKIGTWDPASGLNMTENQKGKTANVTDSLSNRSLVVSTILEEPYVMFKKS 449

  Fly    92 DFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD---RSLIEMVNS 153
            |.||...:..|       |....::..|.....|.||:.:.:|...|:..:..   ..::..:..
Zfish   450 DKPLYGNDRFE-------GYCVDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWNGMVRELMD 507

  Fly   154 STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVM------QRPRESASG-SGLLAPFEFWVWI 211
            ...|||.|.:       :..|.....:|..:..|.:      ::|..:..| ...|.|....:|:
Zfish   508 HKADLAVAPL-------AITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWM 565

  Fly   212 LILVSLLAVGPIIYALIILRNRLT-------------GDGQQTPYSLGHCAWFVYGALMKQGSTL 263
            .||::.|.|..:::.:.    |.:             .|..:..::|.:..||..||||:|||.|
Zfish   566 YILLAYLGVSCVLFVIA----RFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL 626

  Fly   264 SPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEY 328
            .|.|.|||::...||.|..|:.|.|||||.||||:.:...|.::.:|:..:.|         :||
Zfish   627 MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK---------IEY 682

  Fly   329 AIRTTNESLSMLNR------------MIQNNYAVFSDETNDTYNLQNYVEK---NGYVFVRDRPA 378
            .:.....:::...:            |....::|.      ..:::..:|:   :.|.|:.:...
Zfish   683 GVVEDGSTMTFFKKTKISTYDKMWEFMSSRRHSVM------VKSIEEGIERVLTSDYAFLMESTT 741

  Fly   379 INIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAY----PIGSNLSQLFDPELLHLVE 439
            |..:..|:....:.....|.|                   ||    |:||.........:|.|.|
Zfish   742 IEFVTQRNCNLTQIGGLIDSK-------------------AYGVGTPMGSPYRDKITIAILQLQE 787

  Fly   440 SGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQ 504
            .|.: |:.|........||::.......|...::...:.::.||...::.|...|.:::   |:|
Zfish   788 EGKL-HMMKEKWWRGNGCPEEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYK---SKQ 848

  Fly   505 EA 506
            .|
Zfish   849 NA 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	81/405 (20%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	7/28 (25%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	86/422 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840