DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and grid2

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	686	Identity:	156/686 - (22%)
Similarity:	265/686 - (38%)	Gaps:	145/686 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TNLIQMGENGTLSPVTELPMDVDASEAGFDADAPVETLET---INRKKPKL--REMLDWIGGKHL 85
            |:|::..:||: :|  .:..::..:..|.|....|..|.|   |:.....|  |::.:.:.|..|
Zfish   382 TSLLEFNDNGS-NP--NIHFEILGTNYGEDRGRGVSRLATWDPIHGLNGTLTDRKLENNMRGVVL 443

  Fly    86 RIATLEDFPLSYTEVLEN---GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD--- 144
            |:.|:.:.|  :..|.||   ..:...|.|..::|.|.....|.||:.|..|:..|| ...|
Zfish   444 RVVTVLEEP--FVMVSENVLGKPKKYQGFSIDVLDALANYLGFKYEIYVAPDHKYGS-QQADGTW 505

  Fly   145 RSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWV 209
            ..||..:.....|:..:.:....::.|.|.::|..:|....:: :::...:......||||:..:
Zfish   506 NGLIGELVFKRADVGLSALTITPERESVVDFTTRYMDYSVGVL-LRKAERTVDMFACLAPFDLSL 569

  Fly   210 WILILVSLLAVGPIIYALIILRNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLF 274
            |..|..::|.||.::|.|..|.......|..:..:|.:..|||||:.::||..:.....:||::.
Zfish   570 WACIAGTVLLVGTLVYLLNWLNPPRLPMGSVSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMM 634

  Fly   275 ATWWIFITILTSFYTANLTAFLTLSKF--------------TLPYNTVNDILTKNKHFVSMRGGG 325
            ..||:|..|:.|.|||||.||||:|:.              .|||.||.|    :..:..:|..|
Zfish   635 GVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAKQTDLPYGTVLD----SAVYDQVRSKG 695

  Fly   326 VEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVE--KNG--------YVFVRDRPAIN 380
            :....|  :...|.:.|||           |.|...:|.||  |.|        :.||.|...:.
Zfish   696 MNPFER--DPMYSQMWRMI-----------NRTGGAENNVEESKEGIRKVKYGRFAFVWDAAVLE 747

  Fly   381 IMLYRD---YLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGI 442
            .:...|   .||..:.:.:|.    .:.||.:.            ||....:|...:|.|.::|.
Zfish   748 YVAINDEDCSLYTVSNNVADR----GYGMAMQH------------GSPYRDIFSQRILELQQNGD 796

  Fly   443 VKHLSKRNLPSAEICPQDLGGTERQLRNGDLM------MTYYIMLAGFATALAVFSTELMFRYVN 501
            :..|..:..|....|  ||.......::|..:      ..::::.||...:..:.:.|..
Zfish   797 MDILKLKWWPRDSPC--DLYSPVGTRKSGSALDIHSFAGVFFVLAAGVVLSCLIATVETW----- 854

  Fly   502 SRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLN-------SGHGQLLGASTHGQNVTP----- 554
                   |.|....|.|:.:............|:|       |.|.|.   ||...::||
Zfish   855 -------WTRRKGSRVPSKEDDKEIDLEHLHHRVNSLCTEDESPHKQF---STSSIDLTPLDMDS 909

  Fly   555 -PPPYQSI-----FNGGSH-------GDPLNRWRRPLANGNALG--NGVLLGGDSEGGVRRLING 604
             |...|::     |. .:|       .:.:....|.|:...|.|  .|.:....:.|..|:
Zfish   910 LPAARQALEQISDFR-NTHITTTTFIPEQIQTLSRSLSAKAAAGFAFGAVQDHRTGGPFRQ---- 969

  Fly   605 RDYMVFRNPNGQSQLVPVRSPSAALFQ------YSY 634
                  |.|||.....||::.|:..:|      :||
Zfish   970 ------RAPNGGFFRSPVKTMSSIPYQPTPAPNFSY 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	97/386 (25%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	11/47 (23%)
		ANF_receptor	42..404	CDD:279440	5/24 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	101/402 (25%)
		Lig_chan	568..841	CDD:278489	75/307 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740