DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and GluRIID

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	107/431 - (24%)
Similarity:	179/431 - (41%)	Gaps:	74/431 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 SYTEVLENGTRVGHGVSF--QIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRS------LIEMVN 152
            |...::.|....|:||..  ::.|  |..||||:.   ...|..||   |:::      :::.:.
  Fly   437 SIDTLIGNNQFQGYGVDLIKELAD--KLGFNFTFR---DGGNDYGS---FNKTTNSTSGMLKEIV 493

  Fly   153 SSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSL 217
            ....|||...:...|::...:.:|...::.|..|:.::..:...:....:.||...||:.:.::.
  Fly   494 EGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAY 558

  Fly   218 LAVGPIIYALIILRNRLTGDGQQTPY-------------SLGHCAWFVYGALMKQGSTLSPIADS 269
            |.|....:.:    .||:......||             ::.:..||..|||::|||.::|.|.|
  Fly   559 LGVSLCFFII----GRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALS 619

  Fly   270 TRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEYAIRTTN 334
            ||.:.|.||.|..|:.|.|||||.||||:...|.|.|:|.| |..||       ..|:|..:.|.
  Fly   620 TRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKD-LADNK-------DDVQYGAKRTG 676

  Fly   335 ESLSMLNRMIQNNYAVFSDETND-----TYNLQNYVEK----NGYVFVRDRPAINIMLYRDYLYR 390
            .:.:..:...:..|...::..|.     ..|.|..|:|    ..|.|:.:..:|.....|:....
  Fly   677 STRNFFSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLT 741

  Fly   391 KTVSFSDEKVHCPFAMAKE-PFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKR--NLP 452
            |.....|||.: ..||.|. |:..|               |:..||.|.|.|::..|..:  |..
  Fly   742 KVGDPLDEKGY-GIAMVKNWPYRDK---------------FNKALLELQEQGVLARLKNKWWNEV 790

  Fly   453 SAEIC---PQDLGGTERQLRNGDLMMTYYIMLAGFATALAV 490
            .|.:|   ..|.|.:|..:.|  |...|.:::.|...::.:
  Fly   791 GAGVCSAKSDDDGPSELGVDN--LSGIYVVLVIGSIISIII 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	93/371 (25%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377
		ANF_receptor	46..380	CDD:279440
		PBP2_iGluR_Kainate	417..788	CDD:270432	97/386 (25%)
		Lig_chan	549..819	CDD:278489	82/299 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840