DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and KaiR1D

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	113/539 - (20%)
Similarity:	214/539 - (39%)	Gaps:	110/539 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TNLIQMGENGTLSPVTELPMD-VDASEAG------FDADAP--VETLETINRKKPKLREMLDWIG 81
            ||:|:....|..   |:..:| |:.:.||      :::..|  :....|.::|:.::.
  Fly   356 TNVIKFDHQGFR---TDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIE------- 410

  Fly    82 GKHLRIATLEDFPLSYTEVLEN-------------GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQ 133
                  |.|::..|..|.:|.|             |.....|.:..:|..:.|...|.|::.:..
  Fly   411 ------ANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVP 469

  Fly   134 DNIIGSPSDFD-------RSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQR 191
            |...||.:...       |.|:|    ...|||.|.:....::...|.::|..::.|..|:..:.
  Fly   470 DGSYGSLNKLTGEWNGMIRELLE----QRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKP 530

  Fly   192 PRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLT-----------GDGQQTPYSL 245
            .::..:....|:|....|||.:..:.|.|..:::.|.    :.|           |:..::.::|
  Fly   531 IKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILA----KFTPYEWPAYTDAHGEKVESQFTL 591

  Fly   246 GHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVND 310
            .:|.||..|:||:||....|.|.|||::...||.|..|:.|.|||||.||||:.:...|..:..|
  Fly   592 LNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAED 656

  Fly   311 ILTKNK-HFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQN--YVE-----K 367
            :..:.: .:.:::||......|  :..:|...||    ::.........:...|  .||     |
  Fly   657 LAKQTRIKYGALKGGSTAAFFR--DSKISTYQRM----WSFMESARPSVFTASNGEGVERVAKGK 715

  Fly   368 NGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDP 432
            ..|.|:.:..:|..:..|:....:.....|.|   .:.:|..|    ...:...|.|.:.:|.:.
  Fly   716 GSYAFLMESTSIEYVTERNCELTQVGGMLDTK---SYGIATPP----NSPYRTAINSVILKLQEE 773

  Fly   433 ELLHLVESGIVK----------HLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATA 487
            ..||::::...|          ..||.:..:.|:...::||            .:.:::.|...|
  Fly   774 GKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGG------------VFVVLMGGMGVA 826

  Fly   488 LAVFSTELMFRYVNSRQEA 506
            ..:...|.:::   ||:.|
  Fly   827 CVIAVCEFVWK---SRKVA 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	88/392 (22%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	10/43 (23%)
		ANF_receptor	42..378	CDD:279440	7/24 (29%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	87/390 (22%)
		Lig_chan	547..823	CDD:278489	67/304 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910