DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and gria4a

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_999971.1 Gene:gria4a / 407735 ZFINID:ZDB-GENE-020125-7 Length:898 Species:Danio rerio


Alignment Length:522 Identity:114/522 - (21%)
Similarity:209/522 - (40%) Gaps:81/522 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 IATLEDFPLSYTEVLEN-----GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRS 146
            :.|:.:.|  |..:.:|     |.....|....:...:.|.....|::.:..|...|:.....:.
Zfish   413 VTTIMEGP--YVMLKKNWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKI 475

  Fly   147 LIEMVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEF 207
            ...||..   ...::|.|.:.....:...:.:|...:..|..||: ::|::|..| ...|.|..:
Zfish   476 WNGMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFLDPLAY 539

  Fly   208 WVWILILVSLLAVGPIIYALIILRNRLT------------GDG---QQTPYSLG--HCAWFVYGA 255
            .:|:.|:.:.:.|..:::    |.:|.:            .||   .|.|...|  :..||..||
Zfish   540 EIWMCIVFAYIGVSVVLF----LVSRFSPYEWHTEEPEEGSDGPPSDQPPNEFGIFNSLWFSLGA 600

  Fly   256 LMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNK-HFV 319
            .|:||...:|.:.|.|::...||.|..|:.|.|||||.||||:.:...|..:..|:..:.: .:.
Zfish   601 FMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYG 665

  Fly   320 SMRGGGVEYAIRTTNESL--SMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIM 382
            ::..|..:...|.:..::  .|.:.|......||:..|.:.. .:....|..|.|          
Zfish   666 TLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGV-ARVRKSKGKYAF---------- 719

  Fly   383 LYRDYLYRKTVS-FSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL 446
                 |...|:: :::::..|...........|....|.|.||.|....:..:|.|.|:|::..|
Zfish   720 -----LLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKL 779

  Fly   447 -SKRNLPSAEICPQDLGGTERQ---LRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEAN 507
             :|......|..|:|.|..::.   |...::...:||::.|...|:.|...|..::   ||.||.
Zfish   780 KNKWWYDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFCYK---SRAEAK 841

  Fly   508 KWARHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQLLGA-STHGQNVTPPPPYQSIFNGGS--HGD 569
            |            ..:..|..:|...||:     :.|: ..:|:.:||..| :::.:|.|  ||.
Zfish   842 K------------LKLTFSEAMRNKARLS-----ITGSLGENGRVLTPDCP-KAVHSGPSYRHGP 888

  Fly   570 PL 571
            .|
Zfish   889 AL 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 18/112 (16%)
Lig_chan 209..458 CDD:459656 62/270 (23%)
gria4aNP_999971.1 PBP1_iGluR_AMPA_GluR4 23..395 CDD:380611
PBP2_iGluR_AMPA_GluR4 408..790 CDD:270445 84/399 (21%)
Blue background indicates that the domain is not in the aligned region.

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