DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir76b and gria3b

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_938174.1 Gene:gria3b / 368416 ZFINID:ZDB-GENE-030616-53 Length:883 Species:Danio rerio


Alignment Length:513 Identity:104/513 - (20%)
Similarity:190/513 - (37%) Gaps:103/513 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 ATLEDFPLSYTEVLE-------------NGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGS 139
            :::|:..:..|.::|             .|.....|....:...:.|.....|.:.:..|...|:
Zfish   408 SSVENRTIVVTTIMEAPYVMYKKNHMHLEGNEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGA 472

  Fly   140 PSDFDRSLIEMVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SG 200
            .....:|...||..   ...|:|.|.:.....:...:.:|...:..|..||: ::|::|..| ..
Zfish   473 RDPETKSWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFS 536

  Fly   201 LLAPFEFWVWILILVSLLAVGPIIYALIILRNRLT------------GDGQQTP-----YSLGHC 248
            .|.|..:.:|:.|:.:.:.|..:::    |.:|.:            .|.|..|     :.:.:.
Zfish   537 FLDPLAYEIWMCIVFAYIGVSVVLF----LVSRFSPYEWQLDETDEVKDPQTPPDPPNDFGIFNS 597

  Fly   249 AWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILT 313
            .||..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|..:..|:..
Zfish   598 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 662

  Fly   314 KNK-HFVSMRGGGVEYAIRTTNESL--SMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRD 375
            :.: .:.::..|..:...|.:..::  .|.:.|.....:||:..|.|..   ..|.|:...|.  
Zfish   663 QTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFAKTTPDGV---ARVRKSKGKFA-- 722

  Fly   376 RPAINIMLYRDYLYRKTVS-FSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVE 439
                       :|...|:: :.:::..|...........|....|.|.||.|....:..:|.|.|
Zfish   723 -----------FLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNE 776

  Fly   440 SGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMT-----YYIMLAGFATALAVFSTELMFRY 499
            .|::..|..:.......|..  ||.:.:.:...|.::     :||::.|...|:.|...|..:: 
Zfish   777 QGLLDKLKNKWWYDKGECGS--GGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYK- 838

  Fly   500 VNSRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQLLGASTHGQNVTPPPP 557
              ||.||.:                                  |....:.||..|.||
Zfish   839 --SRAEAKR----------------------------------LKLEKNAQNYKPAPP 860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 19/119 (16%)
Lig_chan 209..458 CDD:459656 60/269 (22%)
gria3bNP_938174.1 Periplasmic_Binding_Protein_type1 25..398 CDD:471960
PBP2_iGluR_AMPA 412..794 CDD:270433 83/402 (21%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.