DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and GluRIIB

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	109/497 - (21%)
Similarity:	185/497 - (37%)	Gaps:	143/497 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KHLRIATLEDF---PLSYTEVLENGTRVG----------HGVSFQ--------IIDFL-----KK 121
            |..|:...|||   |:.||.    .||||          .||.::        .:|.:     :.
  Fly   407 KQKRLQNKEDFSQKPIRYTV----ATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQEC 467

  Fly   122 KFNFTYEVVVPQDNIIGS----PSDFD---RSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTT 179
            ||:|.:|.|  :||..||    ..::|   |.||:  |::.:.:....|...  :||.|.::...
  Fly   468 KFDFNFEPV--RDNKYGSYDANTDEWDGIIRQLID--NNAQIGICDLTITQA--RRSVVDFTVPF 526

  Fly   180 LDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALII------------LRN 232
            :..|..|:..:.|...|.....|.|:...||:.::::::...   :|||.            :.|
  Fly   527 MQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITA---FALIFTGRIDQYEWDQPVEN 588

  Fly   233 RLTGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLT 297
            ......:|..:.|.:..|.|.|:::.||..|.|.....|||.|.||||..:::..|.|.|.||:|
  Fly   589 VNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFIT 653

  Fly   298 LSKFTLPYNTVNDILTKNK-HFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDET------ 355
            .||......:::|::.:|| .|.::|||........:|::   .|||..|....|..:.
  Fly   654 SSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDT---DNRMAWNKMLSFKPDAFTKNNE 715

  Fly   356 ----------------NDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPF 404
                            .:|.|||.||::|                                 |..
  Fly   716 EGVDRVKLSKGTYAFLMETTNLQYYVQRN---------------------------------CEL 747

  Fly   405 AMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKR-----------NLPSAEICP 458
            ....|.|.:|....|.|:.::........:|.|.|.|.:..|..:           |:|:.:...
  Fly   748 TQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ 812

  Fly   459 QDL---GGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMF 497
            .|:   ||            .:.:::.|....|.:...|.::
  Fly   813 FDMDSVGG------------LFVVLIVGVVVGLVIGVAEFLW 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	97/421 (23%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	95/421 (23%)
		Lig_chan	555..822	CDD:278489	67/317 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840