Protein Alignment Ir76b and GluRIIA

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 126/539 - (23%)
• Similarity: 208/539 - (38%)
• Gaps: 105/539 - (19%)

  Fly    70 KPKLRE-MLDWI--GGKHLRIATLE--------DFPLS---YTEVL-------------EN--GT 105
            ||.:.| |:.|.  .|...|:..||        ||...   ||.|.             ||  |.
  Fly   388 KPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGR 452

  Fly   106 RVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSP--SDFD---RSLIEMVNSSTVDLAAAFIPS 165
            ....|.:..:|..|.:...|.||.::...|...:|  ..:|   |.||:  :.:.:.:....|..
  Fly   453 EKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQWDGIIRKLID--HHAQIGVCDLTITQ 515

  Fly   166 LSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPF--EFWVWILILVSLLAVGPIIYALI 228
            :  :||.|.::...:..|..|:..:.|.|..:....|.||  |.|::::....::.:..:..|.:
  Fly   516 M--RRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARL 578

  Fly   229 ILRNRL-------TGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTS 286
            ..|..|       ..|..:..:::.:..|.:.|::|:||..:.|.....|:|...||.|..::.|
  Fly   579 SYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLS 643

  Fly   287 FYTANLTAFLTLSKFTLPYNTVNDILTKNK-HFVSMRGGGVEYAIRTTNES--LSMLNRMIQNNY 348
            .|||||.||||.:|:.....::.|::.::| ||.|||||........:|::  ....|:|...|.
  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNP 708

  Fly   349 AVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLK 413
            :.|: .||.....:...||.||.|:.:..::...:.|               :|......|...:
  Fly   709 SAFT-STNKEGVARVRKEKGGYAFLMETTSLTYNIER---------------NCDLTQIGEQIGE 757

  Fly   414 KKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL-------------SKRNLPSAEICPQDLGGTE 465
            |....|.|:||:........:|.|.|.|.::.:             |...:...|:...:|||..
  Fly   758 KHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVF 822

  Fly   466 RQLRNGDLMMTYYIMLAGF--------------ATALAVFSTELMFRYVNSRQEANK-WARHGIG 515
            ..|..|.|:   .::|..|              .|....|..||:|        |.| |.|....
  Fly   823 LVLAGGVLI---GVILGIFEFLWNVQNVAVEERVTPWQAFKAELIF--------ALKFWVRKKPM 876

  Fly   516 RTPNGQSVAPSRWLRGWRR 534
            |..:....:.||...|.||
  Fly   877 RISSSSDKSSSRRSSGSRR 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	29/139 (21%)
		Lig_chan	209..458	CDD:459656	61/271 (23%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	6/16 (38%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	90/389 (23%)
		Lig_chan	555..828	CDD:459656	67/288 (23%)