DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and Ir21a

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	132/615 - (21%)
Similarity:	237/615 - (38%)	Gaps:	140/615 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NLIQMGENGTLSPVTELPMDVDASEA---GFDADAPVETLETIN--RKKPKLR----EMLDWIGG 82
            ||:.:||:....|:.|.|..:...:.   |..::.||.....|.  ..:|.:.    :......|
  Fly   215 NLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAG 279

  Fly    83 KHLRIATLEDFPLSYTEVLENGTRVGH----GVSFQIIDFLKKKFNFTYEV-----------VVP 132
            ...:|:.....|..:.....:.:.:|.    ||.|:::..:.|:.||:.::           ||.
  Fly   280 HRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETPTRSNTRGVVD 344

  Fly   133 --QDNIIGSPSDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRES 195
              |:.||....|...|.|.:.....:| :|..:....|..:|:..::..|           |:..
  Fly   345 TIQEQIIERTVDIGMSGIYITQERLMD-SAMSVGHSPDCAAFITLASKAL-----------PKYR 397

  Fly   196 ASGSGLLAPFEFWVWI-LILVSLLAVGPIIYALIILRNRLTGDGQQTPYSLGHCAWFVYGALMKQ 259
            |    ::.||::.||: ||.|.|..:.||::...:..:.|.|:..:    :.:..|:|:|.....
  Fly   398 A----IMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE----VENMFWYVFGMFTNA 454

  Fly   260 GSTLSPIA------DSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHF 318
            .|.....:      :|||||...:|:|..|:||.||.::.||:||..|....::|.|:|......
  Fly   455 FSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLFFRV 519

  Fly   319 VSMRGGGVE-YAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIM 382
            .::..||.| :...:|:...|.|.:.::...:|.....|.|   |::..  .|.|:..:..:
  Fly   520 GTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVT---QSFFW--NYAFLGSKAQL--- 576

  Fly   383 LYRDYLYRKTVSFSDEKV--HCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKH 445
               :||.:.  :||||.:  .....:::|.|...:..|.:|..|......|..:|...:||::..
  Fly   577 ---EYLVQS--NFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAK 636

  Fly   446 L------------SKRNLPSA------EICPQDLGGTERQLRNGDLMMTYYIMLAGF---ATALA 489
            :            |.|.|.::      ||..:     ||||...|....:.:|..|:   ||||.
  Fly   637 INNEVSWVMQRSSSGRLLQASSSNSLREIIQE-----ERQLTTADTEGMFLLMALGYFLGATALV 696

  Fly   490 VFSTELMFRYVNS---------RQEANKWARHGIG--------------RTPNGQSVA--PSRWL 529
               :|::....|.         :..|:.|:....|              |..|.:..|  ..:..
  Fly   697 ---SEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMS 758

  Fly   530 RGWRRLN-----------------SGHGQL 542
            .|.|.||                 :.||||
  Fly   759 FGMRELNLTRATLREIYGSYGAPETDHGQL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	85/380 (22%)
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	73/326 (22%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	64/271 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910