Protein Alignment Ir76b and Gria4

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_058959.2
• Gene: Gria4 / 29629
• RGDID: 61863
• Length: 902
• Species: Rattus norvegicus
• Alignment Length: 548
• Identity: 118/548 - (21%)
• Similarity: 208/548 - (37%)
• Gaps: 139/548 - (25%)

  Fly    86 RIATLEDFPL--SYTEVLENGTRV--------------GH----------GVSFQIIDFLKKKFN 124
            ::..::|.|.  :.|..:||.|.|              .|          |....:...:.|...
  Rat   395 KLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIG 459

  Fly   125 FTYEVVVPQDNIIGSPSDFDRSLIE-MVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEW 185
            ..|::.:..|...|: .|.|..:.. ||..   ...::|.|.:.....:...:.:|...:..|..
  Rat   460 IKYKIAIVPDGKYGA-RDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGIS 523

  Fly   186 IMVMQRPRESASG-SGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLT---------GDGQQ 240
            ||: ::|::|..| ...|.|..:.:|:.|:.:.:.|..:::    |.:|.:         .||::
  Rat   524 IMI-KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF----LVSRFSPYEWHTEEPEDGKE 583

  Fly   241 TP-------YSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTL 298
            .|       :.:.:..||..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:
  Rat   584 GPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 648

  Fly   299 SKFTLP--------------YNTVNDILTK-----------NKHFVSMRGGGVEYAIRTTNESLS 338
            .:...|              |.|::...||           .|.:..||........|||.|.::
  Rat   649 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVA 713

  Fly   339 MLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCP 403
            .: |..:..:|...:.|     :..|:|:        |...:.|        |.....|.|.:
  Rat   714 RV-RKSKGKFAFLLEST-----MNEYIEQ--------RKPCDTM--------KVGGNLDSKGY-- 754

  Fly   404 FAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL-SKRNLPSAEICPQDLGGTER- 466
                         ..|.|.||:|....:..:|.|.|:|::..| :|......|..|:|.|..::
  Rat   755 -------------GVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKT 806

  Fly   467 -QLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEANKWARHGIGRTPNGQSVAPSRWLR 530
             .|...::...:||::.|...|:.|...|..::   ||.||.:            ..:..|..:|
  Rat   807 SALSLSNVAGVFYILVGGLGLAMLVALIEFCYK---SRAEAKR------------MKLTFSEAIR 856

  Fly   531 GWRRLNSGHGQLLGA-STHGQNVTPPPP 557
            ...||:     :.|: ..:|:.:||..|
  Rat   857 NKARLS-----ITGSVGENGRVLTPDCP 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	23/135 (17%)
		Lig_chan	209..458	CDD:459656	67/290 (23%)
Gria4	NP_058959.2	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	0/4 (0%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	90/423 (21%)