DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and Gria3

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_116785.2 Gene:Gria3 / 29628 RGDID:70958 Length:888 Species:Rattus norvegicus


Alignment Length:455 Identity:102/455 - (22%)
Similarity:184/455 - (40%) Gaps:55/455 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 EVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRSLIEMVNS---STVDLAA 160
            |.||...|. .|....:...:.|.....|::.:..|...|:.....:....||..   ...|:|.
  Rat   437 EQLEGNERY-EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAV 500

  Fly   161 AFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEFWVWILILVSLLAVGPII 224
            |.:.....:...:.:|...:..|..||: ::|::|..| ...|.|..:.:|:.|:.:.:.|..::
  Rat   501 APLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 564

  Fly   225 YALIILR-----------NRLTGDGQQTP-----YSLGHCAWFVYGALMKQGSTLSPIADSTRLL 273
            :  ::.|           |....|.|..|     :.:.:..||..||.|:||..:||.:.|.|::
  Rat   565 F--LVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIV 627

  Fly   274 FATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNK-HFVSMRGGGVEYAIRTTNESL 337
            ...||.|..|:.|.|||||.||||:.:...|..:..|:..:.: .:.::..|..:...|.:..::
  Rat   628 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAV 692

  Fly   338 --SMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVS-FSDEK 399
              .|.:.|.....:||:..|.|..   ..|.|:...|.             :|...|:: :.:::
  Rat   693 YEKMWSYMKSAEPSVFTKTTADGV---ARVRKSKGKFA-------------FLLESTMNEYIEQR 741

  Fly   400 VHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL-SKRNLPSAEICPQDLGG 463
            ..|...........|....|.|.||.|....:..:|.|.|.||:..| :|......|...:|.|.
  Rat   742 KPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGS 806

  Fly   464 TER--QLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEANKWARHGIGRTPNGQSVAPS 526
            .::  .|...::...:||::.|...|:.|...|..::   ||.|:.:     :..|.|.|:..|:
  Rat   807 KDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYK---SRAESKR-----MKLTKNTQNFKPA 863

  Fly   527  526
              Rat   864  863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 18/95 (19%)
Lig_chan 209..458 CDD:459656 63/269 (23%)
Gria3NP_116785.2 PBP1_iGluR_AMPA_GluR3 29..403 CDD:380610
PBP2_iGluR_AMPA 416..799 CDD:270433 85/381 (22%)
Blue background indicates that the domain is not in the aligned region.

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